Validation of the atherothrombotic risk score for secondary prevention in patients with acute myocardial infarction: the J-MINUET study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-04-21

AUTHORS

Takuya Hashimoto, Yoshiyasu Minami, Junya Ako, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Teruo Noguchi, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Toshiaki Mano, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shiro Uemura, Tetsuya Tobaru, Keijiro Saku, Shigeru Oshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, Masaharu Ishihara

ABSTRACT

Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention (TRS2°P) is a contemporary risk scoring system for secondary prevention based on nine clinical factors. However, this scoring system has not been validated in other populations. The aim of this study was to validate the TRS2°P in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI) in a nationwide registry cohort. Among 3283 consecutive patients with AMI enrolled in the Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET), a total of 2611 patients who underwent primary PCI were included in this study. The performance of the TRS2°P to predict major adverse cardiovascular events (MACE) composed of all-cause death, non-fatal MI, and non-fatal stroke up to 3 years in the present cohort was evaluated. The TRS2°P had modest discriminative performance in this J-MINUET cohort with a c-statistic of 0.63, similar to that in the derived cohort (TRA2°P-TIMI50, c-statistic 0.67). A strong graded relationship between the TRS2°P and 3-year cardiovascular event rates was also observed in the J-MINUET cohort. Age ≥ 75 years, Killip ≥ 2, prior stroke, peripheral artery disease, anemia, and non-ST-elevation myocardial infarction were identified as independent factors for the incidence of MACE. The TRS2°P modestly predicted secondary cardiovascular events among patients with AMI treated by primary PCI in a nationwide cohort of Japan. Further studies are needed to develop a novel risk score better predicting secondary cardiovascular events. More... »

PAGES

1506-1513

Journal

TITLE

Heart and Vessels

ISSUE

10

VOLUME

36

Author Affiliations

  • Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan
  • Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan
  • Department of Cardiology, Fujita Health University Okazaki Hospital, Okazaki, Japan
  • Cardiovascular Center, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan
  • Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan
  • Department of Cardiology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Cardiology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan
  • Division of Cardiology, Osaka General Medical Center, Osaka, Japan
  • Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan
  • First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
  • Department of Cardiovascular Medicine, The Sakakibara Heart Institute of Okayama, Okayama, Japan
  • Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan
  • Department of Cardiovascular Medicine, Dokkyo Medical University, Tochigi, Japan
  • Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
  • Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan
  • Department of Cardiology, Okinawa Chubu Hospital, Uruma, Japan
  • Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan
  • Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan
  • Department of Cardiovascular Medicine, Suwa Red Cross Hospital, Suwa, Japan
  • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
  • Division of Cardiovascular Medicine, Saitama Medical Center Jichi Medical University, Saitama, Japan
  • Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, Sapporo, Japan
  • Department of Cardiology, Teikyo University, Tokyo, Japan
  • Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
  • Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan
  • Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
  • Department of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Japan
  • Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
  • Division of Coronary Artery Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00380-021-01840-z

    DOI

    http://dx.doi.org/10.1007/s00380-021-01840-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1137348225

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33880614


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