Association between acute myocardial infarction-to-cardiac rupture time and in-hospital mortality risk: a retrospective analysis of multicenter registry data from the ... View Full Text


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Article Info

DATE

2021-01-16

AUTHORS

Kihei Yoneyama, Yuki Ishibashi, Yorihiko Koeda, Tomonori Itoh, Yoshihiro Morino, Takao Shimohama, Junya Ako, Yuji Ilari, Koichiro Yoshioka, Tomoyuki Kunishima, Shu Inami, Tetsuya Ishikawa, Hiroyuki Sugimura, Ken Kozuma, Keiki Sugi, Hideaki Yoshino, Yoshihiro J. Akashi

ABSTRACT

Despite the known association of cardiac rupture with acute myocardial infarction (AMI), it is still unclear whether the clinical characteristics are associated with the risk of in-hospital mortality in patients with AMI complicated by cardiac rupture. The purpose of this study was to investigate the association between the time of cardiac rupture occurrence and the risk of in-hospital mortality after AMI. We conducted a retrospective analysis of multicenter registry data from eight medical universities in Eastern Japan. From 10,278 consecutive patients with AMI, we included 183 patients who had cardiac rupture after AMI, and examined the incidence of in-hospital deaths during a median follow-up of 26 days. Patients were stratified into three groups according to the AMI-to-cardiac rupture time, namely the > 24-h group (n = 111), 24–48-h group (n = 20), and < 48-h group (n = 52). Cox proportional hazards regression analysis was used to estimate the hazard ratio (HR) and the confidence interval (CI) for in-hospital mortality. Around 87 (48%) patients experienced in-hospital death and 126 (67%) underwent a cardiac surgery. Multivariable Cox regression analysis revealed a non-linear association across the three groups for mortality (HR [CI]; < 24 h: 1.0, reference; 24–48 h: 0.73 [0.27–1.86]; > 48 h: 2.25 [1.22–4.15]) after adjustments for age, sex, Killip classification, percutaneous coronary intervention, blood pressure, creatinine, peak creatine kinase myocardial band fraction, left ventricular ejection fraction, and type of rupture. Cardiac surgery was independently associated with a reduction in the HR of mortality (HR [CI]: 0.27 [0.12–0.61]) and attenuated the association between the three AMI-to-cardiac rupture time categories and mortality (statistically non-significant) in the Cox model. These data suggest that the AMI-to-cardiac rupture time contributes significantly to the risk of in-hospital mortality; however, rapid diagnosis and prompt surgical interventions are crucial for improving outcomes in patients with cardiac rupture after AMI. More... »

PAGES

782-789

Journal

TITLE

Heart and Vessels

ISSUE

6

VOLUME

36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-020-01762-2

DOI

http://dx.doi.org/10.1007/s00380-020-01762-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1134631899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33452916


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