Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-01-10

AUTHORS

Norihiko Shinozaki, Tsutomu Murakami, Yohei Ohno, Masataka Nakano, Toshiharu Fujii, Gaku Nakazawa, Fuminobu Yoshimachi, Yuji Ikari

ABSTRACT

Statin therapy has been shown to induce carotid atherosclerotic plaque regression and reduce the periprocedural ischemic complications of carotid artery stenting (CAS). This study assessed the safety and usefulness of pretreatment using a high-dose strong statin (HDSS) to reduce the periprocedural ischemic complications of CAS. We analyzed 117 carotid lesions treated by CAS that were evaluated with magnetic resonance imaging (MRI) within 48 h after the procedure. For 67 lesions, an HDSS (rosuvastatin 20 mg or atorvastatin 40 mg daily) were prescribed from at least 14 days before CAS to at least 14 days after procedure (HDSS group). Clinical and angiographic data, as well as in-hospital outcomes, of the HDSS group were retrospectively compared with 50 lesions with conventional treatment without an HDSS (non-HDSS group). There were no significant differences in the baseline clinical and procedural characteristics between the two groups. There was no side effect related to the HDSS. Stroke rates were similar between the two groups (3.0% in HDSS group vs 8.0% in non-HDSS group, p = 0.22). All were minor strokes. Compared to the non-HDSS group, the HDSS group had a lower frequency of new lesions on diffusion-weighted imaging (DWI) with MRI (25.4% vs 44.0%, p = 0.0345). New ipsilateral DWI-positive rate in the HDSS group was significantly lower than in the non-HDSS group (16.4% vs 34.0%, p = 0.0275). Nonipsilateral (contralateral or posterior circulation) DWI-positive rates were similar between the two groups (13.4% vs 20.0%, p = 0.34). Pretreatment with an HDSS might reduce the periprocedural ischemic complications of CAS. More... »

PAGES

762-768

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-019-01552-5

DOI

http://dx.doi.org/10.1007/s00380-019-01552-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1124007450

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31925501


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