Prasugrel effectively reduces the platelet reactivity units in patients with genetically metabolic dysfunction of cytochrome P450 2C19 who are treated ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-23

AUTHORS

Junichiro Shimamatsu, Ken-ichiro Sasaki, Yoshio Katsuki, Tomohiro Kawasaki, Yoshinobu Murasato, Hidehiko Ajisaka, Hiroyoshi Yokoi, Hideki Tashiro, Atsushi Harada, Yuji Hirakawa, Yuta Ishizaki, Takashi Ishimatsu, Kotaro Kagiyama, Yoshihiro Fukumoto, Tatsuyuki Kakuma, Takafumi Ueno

ABSTRACT

Dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitor is administered following percutaneous coronary intervention (PCI) with coronary stent implantation. Several studies have reported the effects of switching between P2Y12 inhibitors on platelet reactivity (P2Y12 reaction units: PRU), from acute to late phase after PCI. However, the effect of switching at very late phase is unknown. This study examined the effect on PRU in Japanese coronary heart disease patients with long-term DAPT (aspirin + clopidogrel) when switching from clopidogrel to prasugrel. Ninety-six patients were enrolled in this study. The median DAPT duration at enrollment was 1824.0 days. Twenty-three patients with PRU ≥ 208 at enrollment were randomly assigned into either continuing to receive clopidogrel (Continued Group; n = 11) or switching to prasugrel (Switched Group; n = 12). The primary endpoint was the rate of patients who achieved PRU < 208 at the end of 12 weeks of treatment, which was significantly higher in Switched Group relative to Continued Group (90.0% vs. 36.4%; P = 0.024). The secondary endpoint was the PRU at week 12 in groups subdivided according to cytochrome P450 (CYP) 2C19 genotypes. At week 12, extensive metabolizers (EM Group) had 202.3 ± 60.0 and 174.5 ± 22.3 in Continued Group and Switched Group (P = 0.591), respectively; intermediate and poor metabolizers (non-EM Group) had 229.4 ± 36.9 and 148.4 ± 48.4 in Continued Group and Switched Group (P = 0.002), respectively. The PRU for non-EM Group was significantly reduced in Switched Group. Thus, for patients with long-term DAPT (aspirin + clopidogrel) after PCI with coronary stent implantation, switching from clopidogrel to prasugrel resulted in a stable reduction in PRU, regardless of CYP2C19 polymorphism. More... »

PAGES

312-322

Journal

TITLE

Heart and Vessels

ISSUE

3

VOLUME

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-019-01499-7

DOI

http://dx.doi.org/10.1007/s00380-019-01499-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121197947

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31549178


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspirin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clopidogrel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 CYP2C19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug-Eluting Stents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dual Anti-Platelet Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Percutaneous Coronary Intervention", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacogenomic Variants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prasugrel Hydrochloride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Purinergic P2Y Receptor Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Internal Medicine, Tanushimaru Chuo Hospital, Kurume, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
            "Division of Cardiovascular Internal Medicine, Tanushimaru Chuo Hospital, Kurume, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimamatsu", 
        "givenName": "Junichiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasaki", 
        "givenName": "Ken-ichiro", 
        "id": "sg:person.01077456105.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077456105.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Sugi Hospital, Omuta, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Cardiology, Sugi Hospital, Omuta, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katsuki", 
        "givenName": "Yoshio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Cardiovascular Center, Shin Koga Hospital, Kurume, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415758.a", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, Shin Koga Hospital, Kurume, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawasaki", 
        "givenName": "Tomohiro", 
        "id": "sg:person.0736352554.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736352554.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415613.4", 
          "name": [
            "Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murasato", 
        "givenName": "Yoshinobu", 
        "id": "sg:person.01340225064.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340225064.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Internal Medicine, Asakura Medical Association Hospital, Asakura, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Cardiovascular Internal Medicine, Asakura Medical Association Hospital, Asakura, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ajisaka", 
        "givenName": "Hidehiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Internal Medicine, Fukuoka Sanno Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Cardiovascular Internal Medicine, Fukuoka Sanno Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoi", 
        "givenName": "Hiroyoshi", 
        "id": "sg:person.01052603744.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052603744.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Internal Medicine, St. Mary\u2019s Hospital, Kurume, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416532.7", 
          "name": [
            "Division of Cardiovascular Internal Medicine, St. Mary\u2019s Hospital, Kurume, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tashiro", 
        "givenName": "Hideki", 
        "id": "sg:person.01204756226.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204756226.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo Co., Ltd., Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410844.d", 
          "name": [
            "Daiichi Sankyo Co., Ltd., Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "Atsushi", 
        "id": "sg:person.011505621642.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011505621642.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo Co., Ltd., Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410844.d", 
          "name": [
            "Daiichi Sankyo Co., Ltd., Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirakawa", 
        "givenName": "Yuji", 
        "id": "sg:person.013205701271.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013205701271.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizaki", 
        "givenName": "Yuta", 
        "id": "sg:person.013235451037.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235451037.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishimatsu", 
        "givenName": "Takashi", 
        "id": "sg:person.011003361031.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003361031.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kagiyama", 
        "givenName": "Kotaro", 
        "id": "sg:person.015376222671.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015376222671.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukumoto", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0761604214.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761604214.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistics Center, Kurume University, Kurume, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Biostatistics Center, Kurume University, Kurume, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakuma", 
        "givenName": "Tatsuyuki", 
        "id": "sg:person.01152607645.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152607645.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueno", 
        "givenName": "Takafumi", 
        "id": "sg:person.01143564461.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143564461.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.clpt.6100482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010162029", 
          "https://doi.org/10.1038/sj.clpt.6100482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12928-016-0417-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036403138", 
          "https://doi.org/10.1007/s12928-016-0417-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-018-1322-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111010838", 
          "https://doi.org/10.1007/s00380-018-1322-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12928-016-0452-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022456997", 
          "https://doi.org/10.1007/s12928-016-0452-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-09-23", 
    "datePublishedReg": "2019-09-23", 
    "description": "Dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitor is administered following percutaneous coronary intervention (PCI) with coronary stent implantation. Several studies have reported the effects of switching between P2Y12 inhibitors on platelet reactivity (P2Y12 reaction units: PRU), from acute to late phase after PCI. However, the effect of switching at very late phase is unknown. This study examined the effect on PRU in Japanese coronary heart disease patients with long-term DAPT (aspirin\u2009+\u2009clopidogrel) when switching from clopidogrel to prasugrel. Ninety-six patients were enrolled in this study. The median DAPT duration at enrollment was 1824.0\u00a0days. Twenty-three patients with PRU\u2009\u2265\u2009208 at enrollment were randomly assigned into either continuing to receive clopidogrel (Continued Group; n\u2009=\u200911) or switching to prasugrel (Switched Group; n\u2009=\u200912). The primary endpoint was the rate of patients who achieved PRU\u2009<\u2009208 at the end of 12\u00a0weeks of treatment, which was significantly higher in Switched Group relative to Continued Group (90.0% vs. 36.4%; P\u2009=\u20090.024). The secondary endpoint was the PRU at week 12 in groups subdivided according to cytochrome P450 (CYP) 2C19 genotypes. At week 12, extensive metabolizers (EM Group) had 202.3\u2009\u00b1\u200960.0 and 174.5\u2009\u00b1\u200922.3 in Continued Group and Switched Group (P\u2009=\u20090.591), respectively; intermediate and poor metabolizers (non-EM Group) had 229.4\u2009\u00b1\u200936.9 and 148.4\u2009\u00b1\u200948.4 in Continued Group and Switched Group (P\u2009=\u20090.002), respectively. The PRU for non-EM Group was significantly reduced in Switched Group. Thus, for patients with long-term DAPT (aspirin\u2009+\u2009clopidogrel) after PCI with coronary stent implantation, switching from clopidogrel to prasugrel resulted in a stable reduction in PRU, regardless of CYP2C19 polymorphism.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00380-019-01499-7", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "long-term dual antiplatelet therapy", 
      "dual antiplatelet therapy", 
      "percutaneous coronary intervention", 
      "coronary stent implantation", 
      "continued group", 
      "switched group", 
      "stent implantation", 
      "antiplatelet therapy", 
      "P2Y12 inhibitors", 
      "week 12", 
      "drug-eluting stent implantation", 
      "cytochrome P450 2C19 genotype", 
      "coronary heart disease patients", 
      "Median DAPT duration", 
      "rate of patients", 
      "platelet reactivity units", 
      "weeks of treatment", 
      "P450 2C19 genotype", 
      "heart disease patients", 
      "cytochrome P450 2C19", 
      "late phase", 
      "DAPT duration", 
      "primary endpoint", 
      "secondary endpoints", 
      "coronary intervention", 
      "reactivity units", 
      "platelet reactivity", 
      "disease patients", 
      "CYP2C19 polymorphisms", 
      "extensive metabolizers", 
      "metabolic dysfunction", 
      "poor metabolizers", 
      "P450 2C19", 
      "patients", 
      "EM group", 
      "clopidogrel", 
      "prasugrel", 
      "stable reduction", 
      "PRU", 
      "therapy", 
      "metabolizers", 
      "implantation", 
      "endpoint", 
      "group", 
      "enrollment", 
      "inhibitors", 
      "aspirin", 
      "dysfunction", 
      "weeks", 
      "study", 
      "intervention", 
      "treatment", 
      "effect", 
      "duration", 
      "days", 
      "polymorphism", 
      "genotypes", 
      "rate", 
      "reduction", 
      "reactivity", 
      "units", 
      "end", 
      "phase"
    ], 
    "name": "Prasugrel effectively reduces the platelet reactivity units in patients with genetically metabolic dysfunction of cytochrome P450 2C19 who are treated with long-term dual antiplatelet therapy after undergoing drug-eluting stent implantation", 
    "pagination": "312-322", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1121197947"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00380-019-01499-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31549178"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00380-019-01499-7", 
      "https://app.dimensions.ai/details/publication/pub.1121197947"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_826.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00380-019-01499-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01499-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01499-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01499-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01499-7'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      118 URIs      106 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00380-019-01499-7 schema:about N1053b32b4a5c475c98ab8f01d35a2fc8
2 N177aff35a3c24a72929ba2dbac8c4606
3 N1aac4b29144c4b618a36a61c22a25727
4 N1f06b72dba87479e93482f7282ab9ceb
5 N3b05840291fe4fe5bc2dd21602d17b95
6 N3fd04b7ac01d4c599ee448a071eda874
7 N43aa1d42074c4b8ab8b8027835685c8f
8 N444ddfeb776d4e41aa0596fd416244cd
9 N4d1708db09674ca39e8f63b5d40671c0
10 N4d990514be0f4e5aad3d525035838751
11 N5c2099365cb74f9a82b160d97b7c68e3
12 N6028495fa02043858213586da6efccf5
13 N6f392b49ce6e47439572b89943505294
14 N71ab80f2e3c54385bbaba92a6bfaeee3
15 N89ce5c17d1a14922b330af4a8cb4efe9
16 N9dbc85f9d8864f48801b15483d5817a6
17 N9f8d4c5af3994e20be61310e133889a8
18 Nb4bb669895e540d7a610228d9dfaa262
19 Nc8c016f2cbf94e5989afd8349c3148bc
20 Nc90b42929ff74169820ed933cce12b99
21 Nc99c70657cdd4a2196892dd1812f5107
22 Nce8769b0259442698e2ce0b044b44781
23 Nd4d4436bb5074d89b0c7a366b3fc25ed
24 Nd6e193b2537547d1a4ce8719009d93ac
25 Ne285e5fea4874ea98b4b3705e4a4462c
26 Nfe1a988f16784b00bc2454634a227289
27 anzsrc-for:11
28 anzsrc-for:1103
29 schema:author N4788ccf293354b50897f876302d3d577
30 schema:citation sg:pub.10.1007/s00380-018-1322-2
31 sg:pub.10.1007/s12928-016-0417-x
32 sg:pub.10.1007/s12928-016-0452-7
33 sg:pub.10.1038/sj.clpt.6100482
34 schema:datePublished 2019-09-23
35 schema:datePublishedReg 2019-09-23
36 schema:description Dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitor is administered following percutaneous coronary intervention (PCI) with coronary stent implantation. Several studies have reported the effects of switching between P2Y12 inhibitors on platelet reactivity (P2Y12 reaction units: PRU), from acute to late phase after PCI. However, the effect of switching at very late phase is unknown. This study examined the effect on PRU in Japanese coronary heart disease patients with long-term DAPT (aspirin + clopidogrel) when switching from clopidogrel to prasugrel. Ninety-six patients were enrolled in this study. The median DAPT duration at enrollment was 1824.0 days. Twenty-three patients with PRU ≥ 208 at enrollment were randomly assigned into either continuing to receive clopidogrel (Continued Group; n = 11) or switching to prasugrel (Switched Group; n = 12). The primary endpoint was the rate of patients who achieved PRU < 208 at the end of 12 weeks of treatment, which was significantly higher in Switched Group relative to Continued Group (90.0% vs. 36.4%; P = 0.024). The secondary endpoint was the PRU at week 12 in groups subdivided according to cytochrome P450 (CYP) 2C19 genotypes. At week 12, extensive metabolizers (EM Group) had 202.3 ± 60.0 and 174.5 ± 22.3 in Continued Group and Switched Group (P = 0.591), respectively; intermediate and poor metabolizers (non-EM Group) had 229.4 ± 36.9 and 148.4 ± 48.4 in Continued Group and Switched Group (P = 0.002), respectively. The PRU for non-EM Group was significantly reduced in Switched Group. Thus, for patients with long-term DAPT (aspirin + clopidogrel) after PCI with coronary stent implantation, switching from clopidogrel to prasugrel resulted in a stable reduction in PRU, regardless of CYP2C19 polymorphism.
37 schema:genre article
38 schema:isAccessibleForFree true
39 schema:isPartOf N0757bef1eb8d4141b644463727d79d2d
40 N59e86a795abc4aa89cae2d8e7f954d88
41 sg:journal.1095887
42 schema:keywords CYP2C19 polymorphisms
43 DAPT duration
44 EM group
45 Median DAPT duration
46 P2Y12 inhibitors
47 P450 2C19
48 P450 2C19 genotype
49 PRU
50 antiplatelet therapy
51 aspirin
52 clopidogrel
53 continued group
54 coronary heart disease patients
55 coronary intervention
56 coronary stent implantation
57 cytochrome P450 2C19
58 cytochrome P450 2C19 genotype
59 days
60 disease patients
61 drug-eluting stent implantation
62 dual antiplatelet therapy
63 duration
64 dysfunction
65 effect
66 end
67 endpoint
68 enrollment
69 extensive metabolizers
70 genotypes
71 group
72 heart disease patients
73 implantation
74 inhibitors
75 intervention
76 late phase
77 long-term dual antiplatelet therapy
78 metabolic dysfunction
79 metabolizers
80 patients
81 percutaneous coronary intervention
82 phase
83 platelet reactivity
84 platelet reactivity units
85 polymorphism
86 poor metabolizers
87 prasugrel
88 primary endpoint
89 rate
90 rate of patients
91 reactivity
92 reactivity units
93 reduction
94 secondary endpoints
95 stable reduction
96 stent implantation
97 study
98 switched group
99 therapy
100 treatment
101 units
102 week 12
103 weeks
104 weeks of treatment
105 schema:name Prasugrel effectively reduces the platelet reactivity units in patients with genetically metabolic dysfunction of cytochrome P450 2C19 who are treated with long-term dual antiplatelet therapy after undergoing drug-eluting stent implantation
106 schema:pagination 312-322
107 schema:productId N06a6a622dc3e4dea9fab1247dff217e4
108 N7a56895b8dbf4b849bf672f032d4cd92
109 Nd2178af0d11e4b629c102f85a72db51b
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121197947
111 https://doi.org/10.1007/s00380-019-01499-7
112 schema:sdDatePublished 2022-09-02T16:03
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N565192d6d39d45358caae1a27435e710
115 schema:url https://doi.org/10.1007/s00380-019-01499-7
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N06a6a622dc3e4dea9fab1247dff217e4 schema:name dimensions_id
120 schema:value pub.1121197947
121 rdf:type schema:PropertyValue
122 N0757bef1eb8d4141b644463727d79d2d schema:issueNumber 3
123 rdf:type schema:PublicationIssue
124 N1053b32b4a5c475c98ab8f01d35a2fc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Aged, 80 and over
126 rdf:type schema:DefinedTerm
127 N123f942407ed4a0db08fc5ac825e2ad5 rdf:first sg:person.0736352554.19
128 rdf:rest N4870161346b84c128c87ec7ce613bdc3
129 N14e13e4f87f74e0f9a4262cbb44db030 rdf:first sg:person.01052603744.16
130 rdf:rest N20b51edbde184b759d22bf35eba830f9
131 N177aff35a3c24a72929ba2dbac8c4606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged
133 rdf:type schema:DefinedTerm
134 N1aac4b29144c4b618a36a61c22a25727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Polymorphism, Single Nucleotide
136 rdf:type schema:DefinedTerm
137 N1f06b72dba87479e93482f7282ab9ceb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Pharmacogenomic Variants
139 rdf:type schema:DefinedTerm
140 N20b51edbde184b759d22bf35eba830f9 rdf:first sg:person.01204756226.01
141 rdf:rest Nf265108a502c4622a724461a1daa361c
142 N2b9e16ad7a6d483d8782663c8cfb2c29 rdf:first sg:person.013205701271.29
143 rdf:rest Ne5c568563a9249cab4113d42bab99702
144 N33d116b570de4c318e3aaecd263bc8de rdf:first N57c0ee4c407a455c94972749271b567e
145 rdf:rest N14e13e4f87f74e0f9a4262cbb44db030
146 N393e6b00a1a54c79a03ed82cb294026a rdf:first sg:person.01152607645.40
147 rdf:rest Na506e2177e5143d2b1d7a67f564ffb3f
148 N3b05840291fe4fe5bc2dd21602d17b95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Middle Aged
150 rdf:type schema:DefinedTerm
151 N3fd04b7ac01d4c599ee448a071eda874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Adult
153 rdf:type schema:DefinedTerm
154 N43aa1d42074c4b8ab8b8027835685c8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cytochrome P-450 CYP2C19
156 rdf:type schema:DefinedTerm
157 N444ddfeb776d4e41aa0596fd416244cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Drug Substitution
159 rdf:type schema:DefinedTerm
160 N4788ccf293354b50897f876302d3d577 rdf:first Ne24a52545cb442aab2fadf05b843cfcb
161 rdf:rest Nbb880148e6764eb5af3d227d1c35d397
162 N4870161346b84c128c87ec7ce613bdc3 rdf:first sg:person.01340225064.29
163 rdf:rest N33d116b570de4c318e3aaecd263bc8de
164 N4d1708db09674ca39e8f63b5d40671c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Percutaneous Coronary Intervention
166 rdf:type schema:DefinedTerm
167 N4d990514be0f4e5aad3d525035838751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Platelet Aggregation
169 rdf:type schema:DefinedTerm
170 N565192d6d39d45358caae1a27435e710 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 N57c0ee4c407a455c94972749271b567e schema:affiliation grid-institutes:None
173 schema:familyName Ajisaka
174 schema:givenName Hidehiko
175 rdf:type schema:Person
176 N59e86a795abc4aa89cae2d8e7f954d88 schema:volumeNumber 35
177 rdf:type schema:PublicationVolume
178 N5c2099365cb74f9a82b160d97b7c68e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 N6028495fa02043858213586da6efccf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Time Factors
183 rdf:type schema:DefinedTerm
184 N65f0d4c33f5745f58247b92fb817704a rdf:first sg:person.011003361031.10
185 rdf:rest N80ede398b00e4636a4e8630d1399cf17
186 N6f392b49ce6e47439572b89943505294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Drug-Eluting Stents
188 rdf:type schema:DefinedTerm
189 N71ab80f2e3c54385bbaba92a6bfaeee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Dual Anti-Platelet Therapy
191 rdf:type schema:DefinedTerm
192 N7a56895b8dbf4b849bf672f032d4cd92 schema:name pubmed_id
193 schema:value 31549178
194 rdf:type schema:PropertyValue
195 N80ede398b00e4636a4e8630d1399cf17 rdf:first sg:person.015376222671.05
196 rdf:rest Nf160b005f648418eb38bfb5b025615e1
197 N89ce5c17d1a14922b330af4a8cb4efe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Coronary Artery Disease
199 rdf:type schema:DefinedTerm
200 N8ded272666f34c7ba9a979f257e4be78 schema:affiliation grid-institutes:None
201 schema:familyName Katsuki
202 schema:givenName Yoshio
203 rdf:type schema:Person
204 N9dbc85f9d8864f48801b15483d5817a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Treatment Outcome
206 rdf:type schema:DefinedTerm
207 N9f8d4c5af3994e20be61310e133889a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Drug Resistance
209 rdf:type schema:DefinedTerm
210 Na506e2177e5143d2b1d7a67f564ffb3f rdf:first sg:person.01143564461.49
211 rdf:rest rdf:nil
212 Nb4bb669895e540d7a610228d9dfaa262 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Aspirin
214 rdf:type schema:DefinedTerm
215 Nb90277269bdc48339824940010b8069a rdf:first N8ded272666f34c7ba9a979f257e4be78
216 rdf:rest N123f942407ed4a0db08fc5ac825e2ad5
217 Nbb880148e6764eb5af3d227d1c35d397 rdf:first sg:person.01077456105.50
218 rdf:rest Nb90277269bdc48339824940010b8069a
219 Nc8c016f2cbf94e5989afd8349c3148bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Purinergic P2Y Receptor Antagonists
221 rdf:type schema:DefinedTerm
222 Nc90b42929ff74169820ed933cce12b99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Male
224 rdf:type schema:DefinedTerm
225 Nc99c70657cdd4a2196892dd1812f5107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Prasugrel Hydrochloride
227 rdf:type schema:DefinedTerm
228 Nce8769b0259442698e2ce0b044b44781 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Japan
230 rdf:type schema:DefinedTerm
231 Nd2178af0d11e4b629c102f85a72db51b schema:name doi
232 schema:value 10.1007/s00380-019-01499-7
233 rdf:type schema:PropertyValue
234 Nd4d4436bb5074d89b0c7a366b3fc25ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Female
236 rdf:type schema:DefinedTerm
237 Nd6e193b2537547d1a4ce8719009d93ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Risk Factors
239 rdf:type schema:DefinedTerm
240 Ne24a52545cb442aab2fadf05b843cfcb schema:affiliation grid-institutes:None
241 schema:familyName Shimamatsu
242 schema:givenName Junichiro
243 rdf:type schema:Person
244 Ne285e5fea4874ea98b4b3705e4a4462c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Clopidogrel
246 rdf:type schema:DefinedTerm
247 Ne5c568563a9249cab4113d42bab99702 rdf:first sg:person.013235451037.13
248 rdf:rest N65f0d4c33f5745f58247b92fb817704a
249 Nf160b005f648418eb38bfb5b025615e1 rdf:first sg:person.0761604214.95
250 rdf:rest N393e6b00a1a54c79a03ed82cb294026a
251 Nf265108a502c4622a724461a1daa361c rdf:first sg:person.011505621642.79
252 rdf:rest N2b9e16ad7a6d483d8782663c8cfb2c29
253 Nfe1a988f16784b00bc2454634a227289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
254 schema:name Platelet Aggregation Inhibitors
255 rdf:type schema:DefinedTerm
256 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
257 schema:name Medical and Health Sciences
258 rdf:type schema:DefinedTerm
259 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
260 schema:name Clinical Sciences
261 rdf:type schema:DefinedTerm
262 sg:journal.1095887 schema:issn 0910-8327
263 1615-2573
264 schema:name Heart and Vessels
265 schema:publisher Springer Nature
266 rdf:type schema:Periodical
267 sg:person.01052603744.16 schema:affiliation grid-institutes:None
268 schema:familyName Yokoi
269 schema:givenName Hiroyoshi
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052603744.16
271 rdf:type schema:Person
272 sg:person.01077456105.50 schema:affiliation grid-institutes:grid.410781.b
273 schema:familyName Sasaki
274 schema:givenName Ken-ichiro
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077456105.50
276 rdf:type schema:Person
277 sg:person.011003361031.10 schema:affiliation grid-institutes:grid.410781.b
278 schema:familyName Ishimatsu
279 schema:givenName Takashi
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003361031.10
281 rdf:type schema:Person
282 sg:person.01143564461.49 schema:affiliation grid-institutes:grid.410781.b
283 schema:familyName Ueno
284 schema:givenName Takafumi
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143564461.49
286 rdf:type schema:Person
287 sg:person.011505621642.79 schema:affiliation grid-institutes:grid.410844.d
288 schema:familyName Harada
289 schema:givenName Atsushi
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011505621642.79
291 rdf:type schema:Person
292 sg:person.01152607645.40 schema:affiliation grid-institutes:grid.410781.b
293 schema:familyName Kakuma
294 schema:givenName Tatsuyuki
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152607645.40
296 rdf:type schema:Person
297 sg:person.01204756226.01 schema:affiliation grid-institutes:grid.416532.7
298 schema:familyName Tashiro
299 schema:givenName Hideki
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204756226.01
301 rdf:type schema:Person
302 sg:person.013205701271.29 schema:affiliation grid-institutes:grid.410844.d
303 schema:familyName Hirakawa
304 schema:givenName Yuji
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013205701271.29
306 rdf:type schema:Person
307 sg:person.013235451037.13 schema:affiliation grid-institutes:grid.410781.b
308 schema:familyName Ishizaki
309 schema:givenName Yuta
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235451037.13
311 rdf:type schema:Person
312 sg:person.01340225064.29 schema:affiliation grid-institutes:grid.415613.4
313 schema:familyName Murasato
314 schema:givenName Yoshinobu
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340225064.29
316 rdf:type schema:Person
317 sg:person.015376222671.05 schema:affiliation grid-institutes:grid.410781.b
318 schema:familyName Kagiyama
319 schema:givenName Kotaro
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015376222671.05
321 rdf:type schema:Person
322 sg:person.0736352554.19 schema:affiliation grid-institutes:grid.415758.a
323 schema:familyName Kawasaki
324 schema:givenName Tomohiro
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736352554.19
326 rdf:type schema:Person
327 sg:person.0761604214.95 schema:affiliation grid-institutes:grid.410781.b
328 schema:familyName Fukumoto
329 schema:givenName Yoshihiro
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761604214.95
331 rdf:type schema:Person
332 sg:pub.10.1007/s00380-018-1322-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111010838
333 https://doi.org/10.1007/s00380-018-1322-2
334 rdf:type schema:CreativeWork
335 sg:pub.10.1007/s12928-016-0417-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036403138
336 https://doi.org/10.1007/s12928-016-0417-x
337 rdf:type schema:CreativeWork
338 sg:pub.10.1007/s12928-016-0452-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022456997
339 https://doi.org/10.1007/s12928-016-0452-7
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/sj.clpt.6100482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010162029
342 https://doi.org/10.1038/sj.clpt.6100482
343 rdf:type schema:CreativeWork
344 grid-institutes:None schema:alternateName Division of Cardiology, Sugi Hospital, Omuta, Japan
345 Division of Cardiovascular Internal Medicine, Asakura Medical Association Hospital, Asakura, Japan
346 Division of Cardiovascular Internal Medicine, Fukuoka Sanno Hospital, Fukuoka, Japan
347 Division of Cardiovascular Internal Medicine, Tanushimaru Chuo Hospital, Kurume, Japan
348 schema:name Division of Cardiology, Sugi Hospital, Omuta, Japan
349 Division of Cardiovascular Internal Medicine, Asakura Medical Association Hospital, Asakura, Japan
350 Division of Cardiovascular Internal Medicine, Fukuoka Sanno Hospital, Fukuoka, Japan
351 Division of Cardiovascular Internal Medicine, Tanushimaru Chuo Hospital, Kurume, Japan
352 Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan
353 rdf:type schema:Organization
354 grid-institutes:grid.410781.b schema:alternateName Biostatistics Center, Kurume University, Kurume, Japan
355 Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan
356 schema:name Biostatistics Center, Kurume University, Kurume, Japan
357 Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Fukuoka, Japan
358 rdf:type schema:Organization
359 grid-institutes:grid.410844.d schema:alternateName Daiichi Sankyo Co., Ltd., Tokyo, Japan
360 schema:name Daiichi Sankyo Co., Ltd., Tokyo, Japan
361 rdf:type schema:Organization
362 grid-institutes:grid.415613.4 schema:alternateName Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
363 schema:name Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
364 rdf:type schema:Organization
365 grid-institutes:grid.415758.a schema:alternateName Department of Cardiology, Cardiovascular Center, Shin Koga Hospital, Kurume, Japan
366 schema:name Department of Cardiology, Cardiovascular Center, Shin Koga Hospital, Kurume, Japan
367 rdf:type schema:Organization
368 grid-institutes:grid.416532.7 schema:alternateName Division of Cardiovascular Internal Medicine, St. Mary’s Hospital, Kurume, Japan
369 schema:name Division of Cardiovascular Internal Medicine, St. Mary’s Hospital, Kurume, Japan
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...