High shear stress on the coronary arterial wall is related to computed tomography-derived high-risk plaque: a three-dimensional computed tomography and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-11

AUTHORS

Nobuhiro Murata, Takafumi Hiro, Tadateru Takayama, Suguru Migita, Tomoyuki Morikawa, Takehiro Tamaki, Takashi Mineki, Keisuke Kojima, Naotaka Akutsu, Mitsumasa Sudo, Daisuke Kitano, Daisuke Fukamachi, Atsushi Hirayama, Yasuo Okumura

ABSTRACT

Low wall shear stress (WSS) is associated with plaque formation. However, the relationship between WSS and coronary plaque vulnerability remains unclear. Therefore, this study aimed to clarify the in vivo relationship between luminal WSS derived from three-dimensional (3D) computed tomography (CT) and plaque vulnerability within the coronary artery. Forty-three consecutive patients with ischemic heart disease and coronary stenotic lesions were enrolled and underwent coronary angiography and color-coded intravascular ultrasonography (iMap™) followed by multi-slice coronary CT angiography. CT-derived high-risk plaque was defined by specific CT characteristics, including low CT intensity (< 30 HU) and positive remodeling. The Student's t test, Mann-Whitney U test, χ2 test, repeated measures analysis of variance, and logistic and multiple regression were used for statistical analyses. CT-derived high-risk plaque (n = 15) had higher values of maximum and average shear stress than CT-derived stable plaque (474 ± 453 vs. 158 ± 138 Pa, p = 0.018; 4.2 ± 3.1 vs. 1.6 ± 1.2 Pa, p = 0.007, respectively). Compared with patients with CT-derived stable plaque, those with CT-derived high-risk plaque had a higher prevalence of necrotic and lipidic characteristics (44 ± 13 vs. 31 ± 11%, p = 0.001) based on iMap™. Multivariate logistic regression analysis showed that the average WSS and necrotic plus lipidic content were independent determinants of CT-derived high-risk plaque (average WSS: odds ratio 2.996, p = 0.014; necrotic plus lipidic content: odds ratio 1.306, p = 0.036). Our findings suggested that CT-derived high-risk plaque may coexist with high shear stress on the plaque surface. More... »

Journal

TITLE

Heart and Vessels

ISSUE

N/A

VOLUME

N/A

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00380-019-01389-y

    DOI

    http://dx.doi.org/10.1007/s00380-019-01389-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113378519

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30976923


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murata", 
            "givenName": "Nobuhiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan. hiro.takafumi@nihon-u.ac.jp."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiro", 
            "givenName": "Takafumi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takayama", 
            "givenName": "Tadateru", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Migita", 
            "givenName": "Suguru", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morikawa", 
            "givenName": "Tomoyuki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tamaki", 
            "givenName": "Takehiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mineki", 
            "givenName": "Takashi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kojima", 
            "givenName": "Keisuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akutsu", 
            "givenName": "Naotaka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sudo", 
            "givenName": "Mitsumasa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitano", 
            "givenName": "Daisuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukamachi", 
            "givenName": "Daisuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirayama", 
            "givenName": "Atsushi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nihon University", 
              "id": "https://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okumura", 
            "givenName": "Yasuo", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1161/strokeaha.109.558676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001459731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.109.558676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001459731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijcard.2012.04.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005741172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2007.02.059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006003218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000017200.47342.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006319575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(01)01374-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007234338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000178991.71605.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008067564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000178991.71605.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008067564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2007.10.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009157044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2015.05.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010558915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2015.05.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010558915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.02.068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012414634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12928-015-0345-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016966347", 
              "https://doi.org/10.1007/s12928-015-0345-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.112.096438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024782648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.112.096438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024782648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rb/rbw021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025510874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/eye.1994.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025629903", 
              "https://doi.org/10.1038/eye.1994.19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/eye.1994.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025629903", 
              "https://doi.org/10.1038/eye.1994.19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.108.789743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027159373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra043430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027877419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.901678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028705688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000078637.21322.d3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028850334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.660472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030862961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000254684.80662.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034728738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000254684.80662.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034728738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2000.tb06318.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035213005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/hrt.2004.057810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035895995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1002358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037161635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2006.02.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042252033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-02-203372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042608970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2007.03.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042918285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2010.02.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044175507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.21404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045616431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00730.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046168611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0021-9290(92)90058-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047630906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2006.01.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048008103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.282.21.2035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048134927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.22629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050951449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjcard.2005.09.096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051084714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2011.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051486302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000105054.43931.f0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052305234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000105054.43931.f0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052305234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jphs.10r29fm", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053366856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1115/1.2891383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062089972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.17.10.2061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063334401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.17.10.2245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063334425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1259/bjr/15036781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064568041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4244/eijv5i1a21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072399163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074615250", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077957185", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2017.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091830165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2017.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091830165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2017.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091830165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2018.07.075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107480283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2018.07.075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107480283"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-11", 
        "datePublishedReg": "2019-04-11", 
        "description": "Low wall shear stress (WSS) is associated with plaque formation. However, the relationship between WSS and coronary plaque vulnerability remains unclear. Therefore, this study aimed to clarify the in vivo relationship between luminal WSS derived from three-dimensional (3D) computed tomography (CT) and plaque vulnerability within the coronary artery. Forty-three consecutive patients with ischemic heart disease and coronary stenotic lesions were enrolled and underwent coronary angiography and color-coded intravascular ultrasonography (iMap\u2122) followed by multi-slice coronary CT angiography. CT-derived high-risk plaque was defined by specific CT characteristics, including low CT intensity (<\u200930 HU) and positive remodeling. The Student's t test, Mann-Whitney U test, \u03c72 test, repeated measures analysis of variance, and logistic and multiple regression were used for statistical analyses. CT-derived high-risk plaque (n\u2009=\u200915) had higher values of maximum and average shear stress than CT-derived stable plaque (474\u2009\u00b1\u2009453 vs. 158\u2009\u00b1\u2009138\u00a0Pa, p\u2009=\u20090.018; 4.2\u2009\u00b1\u20093.1 vs. 1.6\u2009\u00b1\u20091.2\u00a0Pa, p\u2009=\u20090.007, respectively). Compared with patients with CT-derived stable plaque, those with CT-derived high-risk plaque had a higher prevalence of necrotic and lipidic characteristics (44\u2009\u00b1\u200913 vs. 31\u2009\u00b1\u200911%, p\u2009=\u20090.001) based on iMap\u2122. Multivariate logistic regression analysis showed that the average WSS and necrotic plus lipidic content were independent determinants of CT-derived high-risk plaque (average WSS: odds ratio 2.996, p\u2009=\u20090.014; necrotic plus lipidic content: odds ratio 1.306, p\u2009=\u20090.036). Our findings suggested that CT-derived high-risk plaque may coexist with high shear stress on the plaque surface.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00380-019-01389-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5907672", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1095887", 
            "issn": [
              "0910-8327", 
              "1615-2573"
            ], 
            "name": "Heart and Vessels", 
            "type": "Periodical"
          }
        ], 
        "name": "High shear stress on the coronary arterial wall is related to computed tomography-derived high-risk plaque: a three-dimensional computed tomography and color-coded tissue-characterizing intravascular ultrasonography study.", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00380-019-01389-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113378519"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8511258"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30976923"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00380-019-01389-y", 
          "https://app.dimensions.ai/details/publication/pub.1113378519"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-16T06:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106828_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s00380-019-01389-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01389-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01389-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01389-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-019-01389-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    273 TRIPLES      20 PREDICATES      69 URIs      16 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00380-019-01389-y schema:about anzsrc-for:11
    2 anzsrc-for:1102
    3 schema:author Nb38abbebed324a07ac56715a5244b250
    4 schema:citation sg:pub.10.1007/s12928-015-0345-1
    5 sg:pub.10.1038/eye.1994.19
    6 https://app.dimensions.ai/details/publication/pub.1074615250
    7 https://app.dimensions.ai/details/publication/pub.1077957185
    8 https://doi.org/10.1001/jama.282.21.2035
    9 https://doi.org/10.1002/jcp.21404
    10 https://doi.org/10.1002/jcp.22629
    11 https://doi.org/10.1016/0021-9290(92)90058-9
    12 https://doi.org/10.1016/j.amjcard.2005.09.096
    13 https://doi.org/10.1016/j.atherosclerosis.2011.01.016
    14 https://doi.org/10.1016/j.ijcard.2012.04.102
    15 https://doi.org/10.1016/j.jacc.2006.01.041
    16 https://doi.org/10.1016/j.jacc.2006.02.044
    17 https://doi.org/10.1016/j.jacc.2007.02.059
    18 https://doi.org/10.1016/j.jacc.2007.03.044
    19 https://doi.org/10.1016/j.jacc.2007.10.030
    20 https://doi.org/10.1016/j.jacc.2009.02.068
    21 https://doi.org/10.1016/j.jacc.2010.02.026
    22 https://doi.org/10.1016/j.jacc.2015.05.069
    23 https://doi.org/10.1016/j.jacc.2018.07.075
    24 https://doi.org/10.1016/j.jcmg.2017.01.031
    25 https://doi.org/10.1016/s0735-1097(01)01374-2
    26 https://doi.org/10.1056/nejmoa1002358
    27 https://doi.org/10.1056/nejmra043430
    28 https://doi.org/10.1093/rb/rbw021
    29 https://doi.org/10.1111/j.1749-6632.2000.tb06318.x
    30 https://doi.org/10.1115/1.2891383
    31 https://doi.org/10.1136/hrt.2004.057810
    32 https://doi.org/10.1152/ajpheart.00730.2004
    33 https://doi.org/10.1161/01.atv.0000105054.43931.f0
    34 https://doi.org/10.1161/01.atv.0000178991.71605.18
    35 https://doi.org/10.1161/01.atv.0000254684.80662.44
    36 https://doi.org/10.1161/01.atv.17.10.2061
    37 https://doi.org/10.1161/01.atv.17.10.2245
    38 https://doi.org/10.1161/01.cir.0000017200.47342.10
    39 https://doi.org/10.1161/01.cir.0000078637.21322.d3
    40 https://doi.org/10.1161/circulationaha.106.660472
    41 https://doi.org/10.1161/circulationaha.108.789743
    42 https://doi.org/10.1161/circulationaha.109.901678
    43 https://doi.org/10.1161/circulationaha.112.096438
    44 https://doi.org/10.1161/strokeaha.109.558676
    45 https://doi.org/10.1182/blood-2009-02-203372
    46 https://doi.org/10.1254/jphs.10r29fm
    47 https://doi.org/10.1259/bjr/15036781
    48 https://doi.org/10.4244/eijv5i1a21
    49 schema:datePublished 2019-04-11
    50 schema:datePublishedReg 2019-04-11
    51 schema:description Low wall shear stress (WSS) is associated with plaque formation. However, the relationship between WSS and coronary plaque vulnerability remains unclear. Therefore, this study aimed to clarify the in vivo relationship between luminal WSS derived from three-dimensional (3D) computed tomography (CT) and plaque vulnerability within the coronary artery. Forty-three consecutive patients with ischemic heart disease and coronary stenotic lesions were enrolled and underwent coronary angiography and color-coded intravascular ultrasonography (iMap™) followed by multi-slice coronary CT angiography. CT-derived high-risk plaque was defined by specific CT characteristics, including low CT intensity (&lt; 30 HU) and positive remodeling. The Student's t test, Mann-Whitney U test, χ<sup>2</sup> test, repeated measures analysis of variance, and logistic and multiple regression were used for statistical analyses. CT-derived high-risk plaque (n = 15) had higher values of maximum and average shear stress than CT-derived stable plaque (474 ± 453 vs. 158 ± 138 Pa, p = 0.018; 4.2 ± 3.1 vs. 1.6 ± 1.2 Pa, p = 0.007, respectively). Compared with patients with CT-derived stable plaque, those with CT-derived high-risk plaque had a higher prevalence of necrotic and lipidic characteristics (44 ± 13 vs. 31 ± 11%, p = 0.001) based on iMap™. Multivariate logistic regression analysis showed that the average WSS and necrotic plus lipidic content were independent determinants of CT-derived high-risk plaque (average WSS: odds ratio 2.996, p = 0.014; necrotic plus lipidic content: odds ratio 1.306, p = 0.036). Our findings suggested that CT-derived high-risk plaque may coexist with high shear stress on the plaque surface.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree false
    55 schema:isPartOf sg:journal.1095887
    56 schema:name High shear stress on the coronary arterial wall is related to computed tomography-derived high-risk plaque: a three-dimensional computed tomography and color-coded tissue-characterizing intravascular ultrasonography study.
    57 schema:productId N0eabce5a858f486d902f4e0ec6ce2f4a
    58 N101c0f445747409584279f462f1b5425
    59 N54311165cd7a4f6e9a3b429cf460a801
    60 N6879b5e912d84e2598d490eface07d6a
    61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113378519
    62 https://doi.org/10.1007/s00380-019-01389-y
    63 schema:sdDatePublished 2019-04-16T06:24
    64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    65 schema:sdPublisher N684831da148046b29ae4d9a26f9ed1e5
    66 schema:url http://link.springer.com/10.1007/s00380-019-01389-y
    67 sgo:license sg:explorer/license/
    68 sgo:sdDataset articles
    69 rdf:type schema:ScholarlyArticle
    70 N029a61f25be4462f8de433b2a25f47ab schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    71 schema:familyName Mineki
    72 schema:givenName Takashi
    73 rdf:type schema:Person
    74 N0541f02732e14c5b9bb8b832186de13e rdf:first N164160248ab34071bf49787029c163cb
    75 rdf:rest Nab23a4a727d64b178bc510e1fc5e1386
    76 N0bcb82adca644e42bd15fa618b4a9eea schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    77 schema:familyName Murata
    78 schema:givenName Nobuhiro
    79 rdf:type schema:Person
    80 N0eabce5a858f486d902f4e0ec6ce2f4a schema:name nlm_unique_id
    81 schema:value 8511258
    82 rdf:type schema:PropertyValue
    83 N101c0f445747409584279f462f1b5425 schema:name doi
    84 schema:value 10.1007/s00380-019-01389-y
    85 rdf:type schema:PropertyValue
    86 N164160248ab34071bf49787029c163cb schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    87 schema:familyName Tamaki
    88 schema:givenName Takehiro
    89 rdf:type schema:Person
    90 N34fdfc9088474d7ca24d1b9da613503f rdf:first N80d90c1747624e01abc6af07a55e023e
    91 rdf:rest N8ac81e5b61ee4cb6a065183a3fac8c94
    92 N3688033ad5604f25a38810d3475ac150 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    93 schema:familyName Takayama
    94 schema:givenName Tadateru
    95 rdf:type schema:Person
    96 N36f64340c14c44c29757a417de02b09e schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    97 schema:familyName Hirayama
    98 schema:givenName Atsushi
    99 rdf:type schema:Person
    100 N54311165cd7a4f6e9a3b429cf460a801 schema:name dimensions_id
    101 schema:value pub.1113378519
    102 rdf:type schema:PropertyValue
    103 N59c554af4cbc476f955ea6b6048f9433 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    104 schema:familyName Hiro
    105 schema:givenName Takafumi
    106 rdf:type schema:Person
    107 N684831da148046b29ae4d9a26f9ed1e5 schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 N6879b5e912d84e2598d490eface07d6a schema:name pubmed_id
    110 schema:value 30976923
    111 rdf:type schema:PropertyValue
    112 N7b8c6b58ded64f19946104c22fc43d4d schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    113 schema:familyName Sudo
    114 schema:givenName Mitsumasa
    115 rdf:type schema:Person
    116 N7c9c8f4d0a3f4d2b9997efee58db8c0f rdf:first Nba946fc4480c40cc98db13c43d772c03
    117 rdf:rest rdf:nil
    118 N80d90c1747624e01abc6af07a55e023e schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    119 schema:familyName Kitano
    120 schema:givenName Daisuke
    121 rdf:type schema:Person
    122 N85ec7ba81ff1492498f7644248bc68ec rdf:first N36f64340c14c44c29757a417de02b09e
    123 rdf:rest N7c9c8f4d0a3f4d2b9997efee58db8c0f
    124 N8ac81e5b61ee4cb6a065183a3fac8c94 rdf:first Nd3597da13c8e4317bcca32a1c0546ce3
    125 rdf:rest N85ec7ba81ff1492498f7644248bc68ec
    126 N91c0332c33ec4c5a93184dcce99283c5 rdf:first N59c554af4cbc476f955ea6b6048f9433
    127 rdf:rest Ne4843bc7efeb46719327b2f02a0b9e1a
    128 Na6d5590c0f5b4b419a2a1a18792776f9 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    129 schema:familyName Kojima
    130 schema:givenName Keisuke
    131 rdf:type schema:Person
    132 Nab23a4a727d64b178bc510e1fc5e1386 rdf:first N029a61f25be4462f8de433b2a25f47ab
    133 rdf:rest Nf4360a58af564aa7b87cb84f38d14475
    134 Nb167172c1e0943efbe8aa7cec86261dd rdf:first Nca1d93f59deb4f539a0fb52e861389b9
    135 rdf:rest Neb15477139ac4818bb677c8bdba863bb
    136 Nb38abbebed324a07ac56715a5244b250 rdf:first N0bcb82adca644e42bd15fa618b4a9eea
    137 rdf:rest N91c0332c33ec4c5a93184dcce99283c5
    138 Nba946fc4480c40cc98db13c43d772c03 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    139 schema:familyName Okumura
    140 schema:givenName Yasuo
    141 rdf:type schema:Person
    142 Nc46117f782af4d558fd0c377be1e1b53 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    143 schema:familyName Akutsu
    144 schema:givenName Naotaka
    145 rdf:type schema:Person
    146 Nca1d93f59deb4f539a0fb52e861389b9 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    147 schema:familyName Migita
    148 schema:givenName Suguru
    149 rdf:type schema:Person
    150 Nd3597da13c8e4317bcca32a1c0546ce3 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    151 schema:familyName Fukamachi
    152 schema:givenName Daisuke
    153 rdf:type schema:Person
    154 Ne4843bc7efeb46719327b2f02a0b9e1a rdf:first N3688033ad5604f25a38810d3475ac150
    155 rdf:rest Nb167172c1e0943efbe8aa7cec86261dd
    156 Neb15477139ac4818bb677c8bdba863bb rdf:first Nf97be44cbfba47d3a093de0746a6d7a4
    157 rdf:rest N0541f02732e14c5b9bb8b832186de13e
    158 Nf4360a58af564aa7b87cb84f38d14475 rdf:first Na6d5590c0f5b4b419a2a1a18792776f9
    159 rdf:rest Nf547a89ac5b944cabfcad1c7572fd617
    160 Nf547a89ac5b944cabfcad1c7572fd617 rdf:first Nc46117f782af4d558fd0c377be1e1b53
    161 rdf:rest Nf6614d4ac3d549648273879dcf842bf2
    162 Nf6614d4ac3d549648273879dcf842bf2 rdf:first N7b8c6b58ded64f19946104c22fc43d4d
    163 rdf:rest N34fdfc9088474d7ca24d1b9da613503f
    164 Nf97be44cbfba47d3a093de0746a6d7a4 schema:affiliation https://www.grid.ac/institutes/grid.260969.2
    165 schema:familyName Morikawa
    166 schema:givenName Tomoyuki
    167 rdf:type schema:Person
    168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Medical and Health Sciences
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Cardiorespiratory Medicine and Haematology
    173 rdf:type schema:DefinedTerm
    174 sg:grant.5907672 http://pending.schema.org/fundedItem sg:pub.10.1007/s00380-019-01389-y
    175 rdf:type schema:MonetaryGrant
    176 sg:journal.1095887 schema:issn 0910-8327
    177 1615-2573
    178 schema:name Heart and Vessels
    179 rdf:type schema:Periodical
    180 sg:pub.10.1007/s12928-015-0345-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016966347
    181 https://doi.org/10.1007/s12928-015-0345-1
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/eye.1994.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025629903
    184 https://doi.org/10.1038/eye.1994.19
    185 rdf:type schema:CreativeWork
    186 https://app.dimensions.ai/details/publication/pub.1074615250 schema:CreativeWork
    187 https://app.dimensions.ai/details/publication/pub.1077957185 schema:CreativeWork
    188 https://doi.org/10.1001/jama.282.21.2035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048134927
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1002/jcp.21404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045616431
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1002/jcp.22629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050951449
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1016/0021-9290(92)90058-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047630906
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/j.amjcard.2005.09.096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051084714
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/j.atherosclerosis.2011.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051486302
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.ijcard.2012.04.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005741172
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.jacc.2006.01.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048008103
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.jacc.2006.02.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042252033
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.jacc.2007.02.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006003218
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.jacc.2007.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042918285
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.jacc.2007.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009157044
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.jacc.2009.02.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012414634
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.jacc.2010.02.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044175507
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.jacc.2015.05.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010558915
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.jacc.2018.07.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107480283
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.jcmg.2017.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091830165
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/s0735-1097(01)01374-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007234338
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1056/nejmoa1002358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037161635
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1056/nejmra043430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027877419
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1093/rb/rbw021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025510874
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1111/j.1749-6632.2000.tb06318.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035213005
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1115/1.2891383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062089972
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1136/hrt.2004.057810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035895995
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1152/ajpheart.00730.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046168611
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1161/01.atv.0000105054.43931.f0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052305234
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1161/01.atv.0000178991.71605.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008067564
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1161/01.atv.0000254684.80662.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034728738
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1161/01.atv.17.10.2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063334401
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1161/01.atv.17.10.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063334425
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1161/01.cir.0000017200.47342.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006319575
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1161/01.cir.0000078637.21322.d3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028850334
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1161/circulationaha.106.660472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862961
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1161/circulationaha.108.789743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027159373
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1161/circulationaha.109.901678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028705688
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1161/circulationaha.112.096438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024782648
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1161/strokeaha.109.558676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001459731
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1182/blood-2009-02-203372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042608970
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1254/jphs.10r29fm schema:sameAs https://app.dimensions.ai/details/publication/pub.1053366856
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1259/bjr/15036781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064568041
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.4244/eijv5i1a21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072399163
    269 rdf:type schema:CreativeWork
    270 https://www.grid.ac/institutes/grid.260969.2 schema:alternateName Nihon University
    271 schema:name Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan.
    272 Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho Itabashi-ku, Tokyo, 173-8610, Japan. hiro.takafumi@nihon-u.ac.jp.
    273 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...