Randomized comparison between 2-link cell design biolimus A9-eluting stent and 3-link cell design everolimus-eluting stent in patients with de novo ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-11

AUTHORS

Masahiro Yamawaki, Toshiya Muramatsu, Kazuhiro Ashida, Koichi Kishi, Yoshihiro Morino, Yoshihisa Kinoshita, Takashi Fujii, Yuichi Noguchi, Shingo Hosogi, Kazuya Kawai, Kiyoshi Hibi, Yoshisato Shibata, Hiroshi Ohira, Yasuhiro Morita, Yasuhiro Tarutani, Mikihito Toda, Yoshihisa Shimada, Yuji Ikari, Jiro Ando, Yutaka Hikichi, Yoritaka Otsuka, Yasushi Fuku, Shigenori Ito, Harumi Katoh, Kazushige Kadota, Yoshiaki Ito, Kazuaki Mitsudo

ABSTRACT

The appropriate stent platform for treating coronary bifurcation lesions (CBLs) remains controversial. Previous bench tests have demonstrated the superiority of a 2-link cell design to 3-link cell design for creating inter-strut dilation at the side branch ostium. This randomized multicenter prospective BEGIN trial compared the biodegradable polymer-based biolimus A9-eluting stent (2-link BES) with the durable polymer-based cobalt chromium everolimus-eluting stent (3-link EES) in 226 patients with de novo CBLs. Patients with true bifurcations, defined as > 50% stenosis in the main vessel and side branch (SB) and an SB diameter > 2.25 mm, were enrolled. Guide wire re-crossing to the distal cell (near the carina) in the jailed SB and final kissing inflation were recommended. The SB angiographic endpoint was < 50% stenosis diameter. Left-main CBLs (13.5% vs. 13.0%) and 2-stent technique (30.6% vs. 22.6%) rates were similar. The primary endpoints (minimum lumen diameter at the SB ostium measured at an independent core laboratory at the 8-month follow-up) were comparable (1.64 ± 0.50 mm vs. 1.63 ± 0.51 mm, p = 0.976). There was no significant difference in composite outcomes of cardiac death, myocardial infarction, or target vascular revascularization at 12 months (7.4% vs. 8.0%, p = 0.894). Two-link BES and 3-link EES showed similar 8-month angiographic and 1-year clinical outcomes for true CBLs. More... »

PAGES

1297-1308

Journal

TITLE

Heart and Vessels

ISSUE

8

VOLUME

34

Author Affiliations

  • Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, 3-6-1 Shimosueyoshi Tsurumi, 230-8765, Yokohama, Japan
  • Department of Cardiology, General Tokyo Hospital, Tokyo, Japan
  • Department of Cardiology, Yokohama Shintoshi Neurosurgery Hospital, Yokohama, Japan
  • Department of Cardiology, Tokushima Red Cross Hospital, Komatsushima, Japan
  • Department of Cardiology, Iwate Medical University Hospital, Morioka, Japan
  • Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan
  • Department of Cardiology, Ako City Hospital, Ako, Japan
  • Department of Cardiology, Tsukuba Medical Center, Tsukuba, Japan
  • Department of Cardiology, Kochi Medical Center, Kochi, Japan
  • Department of Cardiology, Chikamori Hospital, Kochi, Japan
  • Department of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan
  • Department of Cardiology, Edogawa Hospital, Tokyo, Japan
  • Department of Cardiology, Ogaki City Hospital, Ogaki, Japan
  • Department of Cardiology, Okamura Memorial Hopsital, Shimizu-cho, Japan
  • Department of Cardiology, Toho University Oomori Hospital, Tokyo, Japan
  • Department of Cardiology, Shiroyama Hospital, Habikino, Japan
  • Department of Cardiology, Tokai University Hospital, Isehara, Japan
  • Department of Cardiology, Tokyo University Hospital, Tokyo, Japan
  • Department of Cardiology, Saga University Hospital, Saga, Japan
  • Department of Cardiology, Fukuoka Wajiro Hospital, Fukuoka, Japan
  • Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan
  • Department of Cardiology, Sankuro Hospital, Toyota, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00380-019-01368-3

    DOI

    http://dx.doi.org/10.1007/s00380-019-01368-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112683272

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30859377


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