Differential effect of concomitant antidiabetic agents on carotid atherosclerosis: a subgroup analysis of the PROLOGUE study View Full Text


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Article Info

DATE

2018-10-03

AUTHORS

Atsushi Tanaka, Atsushi Kawaguchi, Jun-ichi Oyama, Tomoko Ishizu, Hiroshi Ito, Jun Fukui, Taizo Kondo, Shigetaka Kuroki, Mamoru Nanasato, Yukihito Higashi, Kohei Kaku, Teruo Inoue, Toyoaki Murohara, Koichi Node

ABSTRACT

Accumulated evidence shows that some antidiabetic agents attenuate the progression of carotid atherosclerosis assessed as intima-media thickness (IMT). Although some studies have demonstrated an inhibitory effect of dipeptidyl peptidase-4 inhibitors on carotid IMT progression, in the PROLOGUE study sitagliptin failed to slow progression relative to conventional therapy for 24 months. We hypothesized that differences in the concomitant antidiabetic agents between the groups have influenced the progression of carotid IMT. We performed a post hoc analysis of the PROLOGUE study using subgroups stratified by concomitant antidiabetic agents. Although no subgroup with any combination of agents in the overall patients showed a significant difference between sitagliptin group and conventional therapy group in the changes from baseline in mean common carotid artery (CCA)-IMT at 24 months, a significant attenuation of mean CCA-IMT progression was observed in the sitagliptin group relative to conventional therapy group only in three combination subgroups aged < 70 years, namely no thiazolidinedione; no thiazolidinedione or biguanide; and no thiazolidinedione, biguanide or α-glucosidase inhibitor, even after adjustment for multiple confounding factors. In the three subgroups, no significant difference between sitagliptin group and conventional therapy group in the changes from baseline in HbA1c at 24 months was detected. Our data suggest that some concomitant agents, whose prescription frequencies were increased in the conventional therapy group, may have masked the inhibitory effect of sitagliptin on carotid IMT progression in the PROLOGUE study. More... »

PAGES

375-384

References to SciGraph publications

  • 2013-04-09. Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative in DIABETOLOGIA
  • 2004-11-24. Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes in DIABETOLOGIA
  • 2018-05-22. Stabilization of symptomatic carotid atherosclerotic plaques by statins: a clinico-pathological analysis in HEART AND VESSELS
  • 2015-09-29. Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes in CARDIOVASCULAR DIABETOLOGY
  • 2010-12-09. Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up in HEART AND VESSELS
  • 2014-02-04. The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms in CARDIOVASCULAR DIABETOLOGY
  • 2016-06-21. Metformin promotes cholesterol efflux in macrophages by up-regulating FGF21 expression: a novel anti-atherosclerotic mechanism in LIPIDS IN HEALTH AND DISEASE
  • 2018-02-09. Comparison of the effects of linagliptin and voglibose on endothelial function in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, pilot study (EFFORT) in HEART AND VESSELS
  • 2012-05-18. Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe−/− mice in DIABETOLOGIA
  • Journal

    TITLE

    Heart and Vessels

    ISSUE

    2

    VOLUME

    34

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00380-018-1275-5

    DOI

    http://dx.doi.org/10.1007/s00380-018-1275-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107372144

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30284018


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