Linagliptin prevents atrial electrical and structural remodeling in a canine model of atrial fibrillation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05-02

AUTHORS

Tazuru Igarashi, Shinichi Niwano, Hiroe Niwano, Tomoharu Yoshizawa, Hironori Nakamura, Hidehira Fukaya, Tamami Fujiishi, Naruya Ishizue, Akira Satoh, Jun Kishihara, Masami Murakami, Junya Ako

ABSTRACT

Dipeptidyl peptidase 4 (DPP-4) inhibitors have recently been reported to exhibit additional cardioprotective effects; however, their effect in atrial remodeling, such as in atrial fibrillation (AF), remains unclear. In this study, the effect of linagliptin on atrial electrical and structural remodeling was evaluated in a canine AF model. Sixteen beagle dogs with 3-week atrial rapid stimulation were divided into the linagliptin group (9 mg/kg/day, n = 8) and pacing control group (n = 8). Three additional dogs without rapid pacing were assigned into non-pacing group, which was used as sham in this study. In the dogs with rapid pacing, the atrial effective refractory period (AERP), conduction velocity (CV), and AF inducibility were evaluated and blood was sampled every week. After the entire protocol, atrial tissue was sampled for histological examinations using HE, Azan, and dihydroethidium (DHE) staining to evaluate any tissue damage or oxidative stress. The pacing control group exhibited a gradual AERP shortening and CV decrease along the time course as previously reported. In the linagliptin group, the AERP shortening was not affected, but the CV decrease was suppressed in comparison to the control group (p < 0.05). The AF inducibility was increased in the control group and suppressed in the linagliptin group (p < 0.05). The control group exhibited tissue fibrosis, the degree of which was suppressed in the linagliptin group. DHE staining exhibited suppression of the reactive oxygen species expression in the linagliptin group in comparison to the pacing control group. Linagliptin, a DPP-4-inhibitor, suppressed the AF inducibility, CV decrease, and overexpression of oxidative stress in the canine AF model. Such suppressive effects of linagliptin on AF in the canine model may possibly be related to the anti-oxidative effect. More... »

PAGES

1258-1265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-018-1170-0

DOI

http://dx.doi.org/10.1007/s00380-018-1170-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103760981

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29721673


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78 reactive oxygen species (ROS) expression
79 refractory period
80 remodeling
81 sham
82 shortening
83 species expression
84 stimulation
85 stress
86 structural remodeling
87 study
88 such suppressive effects
89 suppression
90 suppressive effect
91 time course
92 tissue
93 tissue damage
94 tissue fibrosis
95 velocity
96 weeks
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