Can we rely on Danish? Real-world data on patients with nonischemic cardiomyopathy from the German Device Registry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-03

AUTHORS

Gerrit Frommeyer, Dietrich Andresen, Hüseyin Ince, Sebastian Maier, Christoph Stellbrink, Thomas Kleemann, Karlheinz Seidl, Ellen Hoffmann, Bernhard Zrenner, Matthias Hochadel, Jochen Senges, Lars Eckardt

ABSTRACT

According to current guidelines prophylactic implantable cardioverter-defibrillator (ICD) therapy is recommended in patients with significantly impaired left ventricular systolic function. However, the recently published DANISH trial did not find a significantly lower long-term rate of death from any cause compared with usual clinical care in patients with non-ischemic cardiomyopathy. We investigated whether registry data from a multi-center ‘real-life’ registry on patients with non-ischemic cardiomyopathy are similar to this trial. The German Device Registry (DEVICE) is a nationwide, prospective registry with one-year follow-up investigating 5451 patients receiving device implantations in 50 German centers. The present analysis of DEVICE focused on patients with non-ischemic cardiomyopathy and a left ventricular ejection fraction ≤35% who received a prophylactic ICD. Out of 779 patients with symptomatic heart failure and nonischemic cardiomyopathy, 33.1% received a single chamber ICD (VVI), while 11.0% were implanted with a dual-chamber ICD (DDD), and 55.8% received a defibrillator system for cardiac resynchronization therapy. Median follow-up was 16.1 months. 90.7% were alive at follow-up, 9.3% had died during this period. Overall mortality after one year was 5.4%. Overall mortality one year after implantation was significantly increased in patients 68 years and older(7.9%) as compared to younger patients (59–68 years: 2.5%; < 59 years: 3.8%; p < 0.015). Data from the present registry support the recently published results of the DANISH trial. In particular the influence of an increased age as proven in the DANISH trial might also play a role in the present collective. This limits the potential beneficial effect of ICD therapy in particular in the elderly population. More... »

PAGES

1196-1202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-018-01337-2

DOI

http://dx.doi.org/10.1007/s00380-018-01337-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111097615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30607538


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