Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-31

AUTHORS

Maki Komiyama, Hiromichi Wada, Koh Ono, Hajime Yamakage, Noriko Satoh-Asahara, Sayaka Shimada, Masaharu Akao, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi, Tatsuya Sawamura, Koji Hasegawa

ABSTRACT

Vessel wall inflammation promotes the destabilization of atherosclerotic plaques. The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) expressed by vascular cells and monocytes. LOX index is calculated by multiplying LOX-1 ligand containing apolipoprotein B level with the soluble LOX-1. A high LOX index reflects an increased risk for stroke and myocardial infarction. However, the change in LOX index after smoking cessation and the relationship between smoking-related variables and LOX index are unknown. Relation of the clinical parameters to the LOX index was examined on 180 subjects (135 males and 45 females) at the first visit to our outpatient clinic for smoking cessation. The impact of smoking cessation on the LOX index was also determined in the 94 subjects (62 males and 32 females) who successfully stopped smoking. Sex-adjusted regression analysis and multivariate analysis identified three independent determinants of the LOX index, namely, low-density lipoprotein-cholesterol (LDL-C; β = 0.311, p < 0.001), high-sensitivity C-reactive protein (β = 0.358, p < 0.001), and expired carbon monoxide concentration reflecting smoking heaviness (β = 0.264, p = 0.003). Body mass index (BMI) significantly increased 3 months after the onset of smoking cessation (p < 0.001). However, the LOX index significantly decreased (p < 0.001), regardless of the rate of increase in BMI post-cessation. The LOX index is closely associated with smoking heaviness as well as dyslipidemia and an inflammation marker. Smoking cessation may induce a decrease in this cardiovascular risk marker, independently of weight gain. More... »

PAGES

9-16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-017-1026-z

DOI

http://dx.doi.org/10.1007/s00380-017-1026-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090938810

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28761986


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29 schema:description Vessel wall inflammation promotes the destabilization of atherosclerotic plaques. The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) expressed by vascular cells and monocytes. LOX index is calculated by multiplying LOX-1 ligand containing apolipoprotein B level with the soluble LOX-1. A high LOX index reflects an increased risk for stroke and myocardial infarction. However, the change in LOX index after smoking cessation and the relationship between smoking-related variables and LOX index are unknown. Relation of the clinical parameters to the LOX index was examined on 180 subjects (135 males and 45 females) at the first visit to our outpatient clinic for smoking cessation. The impact of smoking cessation on the LOX index was also determined in the 94 subjects (62 males and 32 females) who successfully stopped smoking. Sex-adjusted regression analysis and multivariate analysis identified three independent determinants of the LOX index, namely, low-density lipoprotein-cholesterol (LDL-C; β = 0.311, p < 0.001), high-sensitivity C-reactive protein (β = 0.358, p < 0.001), and expired carbon monoxide concentration reflecting smoking heaviness (β = 0.264, p = 0.003). Body mass index (BMI) significantly increased 3 months after the onset of smoking cessation (p < 0.001). However, the LOX index significantly decreased (p < 0.001), regardless of the rate of increase in BMI post-cessation. The LOX index is closely associated with smoking heaviness as well as dyslipidemia and an inflammation marker. Smoking cessation may induce a decrease in this cardiovascular risk marker, independently of weight gain.
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39 apolipoprotein B levels
40 atherosclerotic plaques
41 body mass index
42 carbon monoxide concentration
43 cardiovascular risk markers
44 cells
45 cessation
46 changes
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48 clinical parameters
49 concentration
50 decrease
51 destabilization
52 determinants
53 dyslipidemia
54 first visit
55 gain
56 heaviness
57 high-sensitivity C-reactive protein
58 impact
59 increase
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61 independent determinants
62 index
63 infarction
64 inflammation
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66 lectin-like oxidized low-density lipoprotein receptor-1
67 levels
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81 plaques
82 protein
83 rate
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85 receptor 1
86 receptor index
87 regression analysis
88 relation
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90 risk
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92 sex-adjusted regression analyses
93 smoking cessation
94 smoking heaviness
95 smoking-related variables
96 soluble LOX-1
97 stroke
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