Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05-17

AUTHORS

Masayuki Mori, Kenji Sakata, Chiaki Nakanishi, Takuya Nakahashi, Masa-aki Kawashiri, Kazuaki Yoshioka, Yoh Takuwa, Hirofumi Okada, Jun-ichiro Yokawa, Masaya Shimojima, Tsuyoshi Yoshimuta, Shohei Yoshida, Masakazu Yamagishi, Kenshi Hayashi

ABSTRACT

Although Nobori®, with a bioresorbable polymer and biolimus A9 abluminal coating, has unique characteristics, few data exist regarding endothelialization early after implantation. Fifteen Nobori® and 14 control bare-metal stents (S-stent™) were implanted in 12 pigs. Histopathology of stented segments, inflammation, and intimal fibrin content was evaluated on the 2nd and 14th day after implantation. On the 2nd day, endothelial cells were morphologically and immunohistologically confirmed on the surface of both stents, although some inflammatory cells might be involved. Stent surface endothelialization evaluated with a scanning electron microscope showed partial cellular coverage in both stents. On the 14th day, neointimal thickness and percentage of the neointimal area were significantly lower in Nobori® than in S-stent™ (51.4 ± 4.5 vs. 76.4 ± 23.6 µm, p < 0.05 and 10.8 ± 2.6 vs. 14.1 ± 4.2%, p < 0.01). No significant differences were found in these parameters on the 2nd day (17.3 ± 14.9 vs. 26.7 ± 13.6 µm and 3.7 ± 3.0 vs. 6.7 ± 3.7%), in inflammatory and intimal fibrin content scores. These results demonstrate that endothelialization could occur early after Nobori® implantation with similar inflammatory reaction to bare-metal stents, probably contributing to low frequency of in-stent thrombosis and restenosis. More... »

PAGES

1244-1252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-017-0992-5

DOI

http://dx.doi.org/10.1007/s00380-017-0992-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085422555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28516211


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24 schema:description Although Nobori®, with a bioresorbable polymer and biolimus A9 abluminal coating, has unique characteristics, few data exist regarding endothelialization early after implantation. Fifteen Nobori® and 14 control bare-metal stents (S-stent™) were implanted in 12 pigs. Histopathology of stented segments, inflammation, and intimal fibrin content was evaluated on the 2nd and 14th day after implantation. On the 2nd day, endothelial cells were morphologically and immunohistologically confirmed on the surface of both stents, although some inflammatory cells might be involved. Stent surface endothelialization evaluated with a scanning electron microscope showed partial cellular coverage in both stents. On the 14th day, neointimal thickness and percentage of the neointimal area were significantly lower in Nobori® than in S-stent™ (51.4 ± 4.5 vs. 76.4 ± 23.6 µm, p < 0.05 and 10.8 ± 2.6 vs. 14.1 ± 4.2%, p < 0.01). No significant differences were found in these parameters on the 2nd day (17.3 ± 14.9 vs. 26.7 ± 13.6 µm and 3.7 ± 3.0 vs. 6.7 ± 3.7%), in inflammatory and intimal fibrin content scores. These results demonstrate that endothelialization could occur early after Nobori® implantation with similar inflammatory reaction to bare-metal stents, probably contributing to low frequency of in-stent thrombosis and restenosis.
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41 control bare metal stents
42 coronary model
43 coverage
44 data
45 days
46 differences
47 early endothelialization
48 electron microscope
49 endothelial cells
50 endothelialization
51 fibrin content
52 frequency
53 histopathology
54 implantation
55 inflammation
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58 low frequency
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61 neointimal area
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63 parameters
64 percentage
65 pigs
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67 porcine coronary model
68 reaction
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