Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10-31

AUTHORS

Masa-aki Kawashiri, Kenji Sakata, Kenshi Hayashi, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Hidekazu Ino, Keisuke Nagase, Masakazu Yamagishi, Behalf of the MILLION Study Group

ABSTRACT

The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD. More... »

PAGES

539-548

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2

DOI

http://dx.doi.org/10.1007/s00380-016-0910-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003156526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27798731


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypolipidemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Percutaneous Coronary Intervention", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography, Interventional", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawashiri", 
        "givenName": "Masa-aki", 
        "id": "sg:person.0770006522.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770006522.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakata", 
        "givenName": "Kenji", 
        "id": "sg:person.01316727765.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316727765.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Kenshi", 
        "id": "sg:person.0762321530.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762321530.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gamou", 
        "givenName": "Tadatsugu", 
        "id": "sg:person.0607233257.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607233257.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414830.a", 
          "name": [
            "Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanaya", 
        "givenName": "Honin", 
        "id": "sg:person.01345026327.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345026327.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414830.a", 
          "name": [
            "Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miwa", 
        "givenName": "Kenji", 
        "id": "sg:person.01204163607.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204163607.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Kosei", 
        "id": "sg:person.013703114332.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013703114332.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higashikata", 
        "givenName": "Toshinori", 
        "id": "sg:person.01327061620.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327061620.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan", 
          "id": "http://www.grid.ac/institutes/grid.418045.c", 
          "name": [
            "Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuno", 
        "givenName": "Sumio", 
        "id": "sg:person.0775364574.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775364574.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michishita", 
        "givenName": "Ichiro", 
        "id": "sg:person.0732262025.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Namura", 
        "givenName": "Masanobu", 
        "id": "sg:person.01031754574.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031754574.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nitta", 
        "givenName": "Yutaka", 
        "id": "sg:person.01371020747.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371020747.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katsuda", 
        "givenName": "Shoji", 
        "id": "sg:person.0773063461.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773063461.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415492.f", 
          "name": [
            "Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okeie", 
        "givenName": "Kazuyasu", 
        "id": "sg:person.015312374614.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015312374614.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirase", 
        "givenName": "Hiroaki", 
        "id": "sg:person.0650607067.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650607067.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tada", 
        "givenName": "Hayato", 
        "id": "sg:person.01216703022.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216703022.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchiyama", 
        "givenName": "Katsuharu", 
        "id": "sg:person.01251733764.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251733764.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konno", 
        "givenName": "Tetsuo", 
        "id": "sg:person.01362470722.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362470722.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ino", 
        "givenName": "Hidekazu", 
        "id": "sg:person.01136556735.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136556735.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagase", 
        "givenName": "Keisuke", 
        "id": "sg:person.01226113157.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226113157.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamagishi", 
        "givenName": "Masakazu", 
        "id": "sg:person.01111610241.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111610241.58"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Behalf of the MILLION Study Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00380-014-0522-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032907056", 
          "https://doi.org/10.1007/s00380-014-0522-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-013-0453-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043153415", 
          "https://doi.org/10.1007/s00380-013-0453-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2014.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044401479", 
          "https://doi.org/10.1038/hr.2014.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2013.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041803518", 
          "https://doi.org/10.1038/hr.2013.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-014-0468-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025801560", 
          "https://doi.org/10.1007/s00380-014-0468-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10-31", 
    "datePublishedReg": "2016-10-31", 
    "description": "The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0\u00a0\u00b1\u00a09.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18\u201324\u00a0months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100\u00a0mg/dL and 140/90\u00a0mmHg vs. 70\u00a0mg/dL and 120/70\u00a0mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9\u00a0\u00b1\u00a014.7 vs. 63.7\u00a0\u00b1\u00a011.9\u00a0mg/dL (NS) and 124.1\u00a0\u00b1\u00a09.4/75.8\u00a0\u00b1\u00a07.7 vs. 113.6\u00a0\u00b1\u00a09.6/65.8\u00a0\u00b1\u00a09.4\u00a0mmHg (systolic BP; NS, diastolic BP; p\u00a0<\u00a00.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of \u22129.4\u00a0\u00b1\u00a010.7% and \u22128.7\u00a0\u00b1\u00a08.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00380-016-0910-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "keywords": [
      "coronary artery disease", 
      "percutaneous coronary intervention", 
      "coronary plaque volume", 
      "blood pressure", 
      "plaque volume", 
      "coronary intervention", 
      "lipid lowering", 
      "prevention of CAD", 
      "coronary atherosclerotic plaque volume", 
      "low-density lipoprotein cholesterol", 
      "intravascular ultrasonography study", 
      "blood pressure control", 
      "atherosclerotic plaque volume", 
      "primary endpoint", 
      "aggressive therapy", 
      "lipoprotein cholesterol", 
      "plaque regression", 
      "artery disease", 
      "ultrasonography study", 
      "IVUS examination", 
      "aggressive intervention", 
      "standard treatment", 
      "coronary plaques", 
      "myocardial ischemia", 
      "Japanese patients", 
      "intravascular ultrasonography", 
      "patients", 
      "percent change", 
      "LDL", 
      "pressure control", 
      "mmHg", 
      "aggressive strategy", 
      "aggressive reduction", 
      "significant reduction", 
      "intervention", 
      "target level", 
      "same degree", 
      "ischemia", 
      "evaluation study", 
      "ultrasonography", 
      "therapy", 
      "plaques", 
      "disease", 
      "study", 
      "cholesterol", 
      "baseline", 
      "endpoint", 
      "months", 
      "prevention", 
      "treatment", 
      "total", 
      "volume", 
      "reduction", 
      "examination", 
      "lowering", 
      "group", 
      "regression", 
      "aim", 
      "pressure", 
      "levels", 
      "control", 
      "strategies", 
      "changes", 
      "impact", 
      "degree", 
      "importance", 
      "simultaneous reduction"
    ], 
    "name": "Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study", 
    "pagination": "539-548", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003156526"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00380-016-0910-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27798731"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00380-016-0910-2", 
      "https://app.dimensions.ai/details/publication/pub.1003156526"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_720.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00380-016-0910-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2'


 

This table displays all metadata directly associated to this object as RDF triples.

388 TRIPLES      22 PREDICATES      116 URIs      103 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00380-016-0910-2 schema:about N0016b63663fc49a4afbf96117c0808cc
2 N06526816a95341b6b3b32ffb307a8e0e
3 N0973954d2bee4bfa83b539577a1083d4
4 N1179471294b048439c02bed37cc55b74
5 N248ec87ab2f04479a0a5dca80b6bf125
6 N277980004233453685f69b638b5abab9
7 N349fd23326af4218a01d9ab407b2f1a8
8 N4b165e96efee436cb860374b7b8f52e9
9 N7e8be4a994514ab1b47c2d623c4c9e09
10 N8ba3543705044e22b26953635bba85ff
11 N95f5a77e135546eabb5f0d20cef6b52f
12 Nb9ce7dc156ab4dd2a4558faa0e754705
13 Nbb41c0be8f9b4633ad2166439c51cb08
14 Nce572a26996f416daf68d4474ad7938b
15 Ncff2d5baca984760a9968d6850be7ffb
16 Ne6a12d02ef234c2598b31f642536505c
17 Ne7c1784768644f01947e1b17d9851558
18 Nf9a8adb5dc384110967b24371c3d179b
19 anzsrc-for:11
20 anzsrc-for:1102
21 schema:author N82fc046ae04d40c8a570c750606c5a78
22 schema:citation sg:pub.10.1007/s00380-013-0453-8
23 sg:pub.10.1007/s00380-014-0468-9
24 sg:pub.10.1007/s00380-014-0522-7
25 sg:pub.10.1038/hr.2013.80
26 sg:pub.10.1038/hr.2014.20
27 schema:datePublished 2016-10-31
28 schema:datePublishedReg 2016-10-31
29 schema:description The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N97c78b3615924c09b5441eb21e134c61
34 Nfe11864acea04592a097549c79be208e
35 sg:journal.1095887
36 schema:keywords IVUS examination
37 Japanese patients
38 LDL
39 aggressive intervention
40 aggressive reduction
41 aggressive strategy
42 aggressive therapy
43 aim
44 artery disease
45 atherosclerotic plaque volume
46 baseline
47 blood pressure
48 blood pressure control
49 changes
50 cholesterol
51 control
52 coronary artery disease
53 coronary atherosclerotic plaque volume
54 coronary intervention
55 coronary plaque volume
56 coronary plaques
57 degree
58 disease
59 endpoint
60 evaluation study
61 examination
62 group
63 impact
64 importance
65 intervention
66 intravascular ultrasonography
67 intravascular ultrasonography study
68 ischemia
69 levels
70 lipid lowering
71 lipoprotein cholesterol
72 low-density lipoprotein cholesterol
73 lowering
74 mmHg
75 months
76 myocardial ischemia
77 patients
78 percent change
79 percutaneous coronary intervention
80 plaque regression
81 plaque volume
82 plaques
83 pressure
84 pressure control
85 prevention
86 prevention of CAD
87 primary endpoint
88 reduction
89 regression
90 same degree
91 significant reduction
92 simultaneous reduction
93 standard treatment
94 strategies
95 study
96 target level
97 therapy
98 total
99 treatment
100 ultrasonography
101 ultrasonography study
102 volume
103 schema:name Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
104 schema:pagination 539-548
105 schema:productId Na6c6728ac1d445d098428b5d2f3c33c6
106 Nbcc86d6e56e744bbb6897d8273e06c89
107 Nd091138707194baaa056fd34866cd8af
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003156526
109 https://doi.org/10.1007/s00380-016-0910-2
110 schema:sdDatePublished 2022-06-01T22:15
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N1250087cee2c4c3e9137d5a78c6fabb3
113 schema:url https://doi.org/10.1007/s00380-016-0910-2
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N0016b63663fc49a4afbf96117c0808cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N042d399fe08447959f3370ff4854ec72 rdf:first sg:person.01216703022.43
121 rdf:rest Nd57ae311770f486a972757574c2a54b2
122 N061467a625a548fd862beb821b3e27ea rdf:first sg:person.01345026327.98
123 rdf:rest Nb66ccb8d2ae64ea09cb02e87c4d54e93
124 N06526816a95341b6b3b32ffb307a8e0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Disease Progression
126 rdf:type schema:DefinedTerm
127 N06de5b1fdb1e40d785586ada0b5c2370 rdf:first sg:person.0775364574.73
128 rdf:rest N92dc608d037a460e83832d3c6f435847
129 N0973954d2bee4bfa83b539577a1083d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Aged
131 rdf:type schema:DefinedTerm
132 N0f333c75b8f44885b55fb5520a72899f rdf:first sg:person.0607233257.95
133 rdf:rest N061467a625a548fd862beb821b3e27ea
134 N1179471294b048439c02bed37cc55b74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Myocardial Ischemia
136 rdf:type schema:DefinedTerm
137 N1250087cee2c4c3e9137d5a78c6fabb3 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N14fe04277e8942dcba7d827abcc7648e schema:familyName Behalf of the MILLION Study Group
140 rdf:type schema:Person
141 N18abe91ed7b24fe49ae0bba784b22beb rdf:first sg:person.01136556735.60
142 rdf:rest Nf4400f6c89544a3781e4462b52cd3ab6
143 N248ec87ab2f04479a0a5dca80b6bf125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Hypolipidemic Agents
145 rdf:type schema:DefinedTerm
146 N277980004233453685f69b638b5abab9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Middle Aged
148 rdf:type schema:DefinedTerm
149 N349fd23326af4218a01d9ab407b2f1a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Lipids
151 rdf:type schema:DefinedTerm
152 N3599b6c614764ea8a21240e0862d5840 rdf:first sg:person.01327061620.05
153 rdf:rest N06de5b1fdb1e40d785586ada0b5c2370
154 N3e7ac421469d45058e2642f5e233a19a rdf:first sg:person.01371020747.98
155 rdf:rest N44090a42a3d64170afe069bbcf74821b
156 N44090a42a3d64170afe069bbcf74821b rdf:first sg:person.0773063461.71
157 rdf:rest Ndaa641974e9647a0b9e0c4bd96a666fa
158 N4b165e96efee436cb860374b7b8f52e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Blood Pressure
160 rdf:type schema:DefinedTerm
161 N512d0885ca864513858955d7bb7c9a21 rdf:first sg:person.01111610241.58
162 rdf:rest Ne4cdbc6bab7e484b8a84bf9a901607fc
163 N7a4569df4d1e40559324e46723357472 rdf:first sg:person.0762321530.31
164 rdf:rest N0f333c75b8f44885b55fb5520a72899f
165 N7e8be4a994514ab1b47c2d623c4c9e09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Prospective Studies
167 rdf:type schema:DefinedTerm
168 N8111e2241c494538b7d708a85f327408 rdf:first sg:person.01362470722.15
169 rdf:rest N18abe91ed7b24fe49ae0bba784b22beb
170 N82fc046ae04d40c8a570c750606c5a78 rdf:first sg:person.0770006522.11
171 rdf:rest Neef36614cfcf47578b77b1cf14adbd81
172 N8ba3543705044e22b26953635bba85ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Male
174 rdf:type schema:DefinedTerm
175 N92dc608d037a460e83832d3c6f435847 rdf:first sg:person.0732262025.70
176 rdf:rest Neef1437505a54a7bb33d061b2db6ac2e
177 N95f5a77e135546eabb5f0d20cef6b52f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Coronary Artery Disease
179 rdf:type schema:DefinedTerm
180 N97c78b3615924c09b5441eb21e134c61 schema:volumeNumber 32
181 rdf:type schema:PublicationVolume
182 Na6c6728ac1d445d098428b5d2f3c33c6 schema:name pubmed_id
183 schema:value 27798731
184 rdf:type schema:PropertyValue
185 Nb66ccb8d2ae64ea09cb02e87c4d54e93 rdf:first sg:person.01204163607.43
186 rdf:rest Ncdacd4bd3efd44c7b8356cc3f4d013a0
187 Nb9ce7dc156ab4dd2a4558faa0e754705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Ultrasonography, Interventional
189 rdf:type schema:DefinedTerm
190 Nbb41c0be8f9b4633ad2166439c51cb08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Percutaneous Coronary Intervention
192 rdf:type schema:DefinedTerm
193 Nbcc86d6e56e744bbb6897d8273e06c89 schema:name doi
194 schema:value 10.1007/s00380-016-0910-2
195 rdf:type schema:PropertyValue
196 Ncdacd4bd3efd44c7b8356cc3f4d013a0 rdf:first sg:person.013703114332.12
197 rdf:rest N3599b6c614764ea8a21240e0862d5840
198 Nce572a26996f416daf68d4474ad7938b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Follow-Up Studies
200 rdf:type schema:DefinedTerm
201 Ncff2d5baca984760a9968d6850be7ffb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Time Factors
203 rdf:type schema:DefinedTerm
204 Nd091138707194baaa056fd34866cd8af schema:name dimensions_id
205 schema:value pub.1003156526
206 rdf:type schema:PropertyValue
207 Nd57ae311770f486a972757574c2a54b2 rdf:first sg:person.01251733764.16
208 rdf:rest N8111e2241c494538b7d708a85f327408
209 Ndaa641974e9647a0b9e0c4bd96a666fa rdf:first sg:person.015312374614.34
210 rdf:rest Nede028eed71146d0bcbe8d2ededbe98c
211 Ne4cdbc6bab7e484b8a84bf9a901607fc rdf:first N14fe04277e8942dcba7d827abcc7648e
212 rdf:rest rdf:nil
213 Ne6a12d02ef234c2598b31f642536505c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Antihypertensive Agents
215 rdf:type schema:DefinedTerm
216 Ne7c1784768644f01947e1b17d9851558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Plaque, Atherosclerotic
218 rdf:type schema:DefinedTerm
219 Nede028eed71146d0bcbe8d2ededbe98c rdf:first sg:person.0650607067.51
220 rdf:rest N042d399fe08447959f3370ff4854ec72
221 Neef1437505a54a7bb33d061b2db6ac2e rdf:first sg:person.01031754574.57
222 rdf:rest N3e7ac421469d45058e2642f5e233a19a
223 Neef36614cfcf47578b77b1cf14adbd81 rdf:first sg:person.01316727765.17
224 rdf:rest N7a4569df4d1e40559324e46723357472
225 Nf4400f6c89544a3781e4462b52cd3ab6 rdf:first sg:person.01226113157.11
226 rdf:rest N512d0885ca864513858955d7bb7c9a21
227 Nf9a8adb5dc384110967b24371c3d179b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Female
229 rdf:type schema:DefinedTerm
230 Nfe11864acea04592a097549c79be208e schema:issueNumber 5
231 rdf:type schema:PublicationIssue
232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
233 schema:name Medical and Health Sciences
234 rdf:type schema:DefinedTerm
235 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
236 schema:name Cardiorespiratory Medicine and Haematology
237 rdf:type schema:DefinedTerm
238 sg:journal.1095887 schema:issn 0910-8327
239 1615-2573
240 schema:name Heart and Vessels
241 schema:publisher Springer Nature
242 rdf:type schema:Periodical
243 sg:person.01031754574.57 schema:affiliation grid-institutes:None
244 schema:familyName Namura
245 schema:givenName Masanobu
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031754574.57
247 rdf:type schema:Person
248 sg:person.01111610241.58 schema:affiliation grid-institutes:grid.9707.9
249 schema:familyName Yamagishi
250 schema:givenName Masakazu
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111610241.58
252 rdf:type schema:Person
253 sg:person.01136556735.60 schema:affiliation grid-institutes:None
254 schema:familyName Ino
255 schema:givenName Hidekazu
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136556735.60
257 rdf:type schema:Person
258 sg:person.01204163607.43 schema:affiliation grid-institutes:grid.414830.a
259 schema:familyName Miwa
260 schema:givenName Kenji
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204163607.43
262 rdf:type schema:Person
263 sg:person.01216703022.43 schema:affiliation grid-institutes:grid.9707.9
264 schema:familyName Tada
265 schema:givenName Hayato
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216703022.43
267 rdf:type schema:Person
268 sg:person.01226113157.11 schema:affiliation grid-institutes:grid.9707.9
269 schema:familyName Nagase
270 schema:givenName Keisuke
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226113157.11
272 rdf:type schema:Person
273 sg:person.01251733764.16 schema:affiliation grid-institutes:grid.9707.9
274 schema:familyName Uchiyama
275 schema:givenName Katsuharu
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251733764.16
277 rdf:type schema:Person
278 sg:person.01316727765.17 schema:affiliation grid-institutes:grid.9707.9
279 schema:familyName Sakata
280 schema:givenName Kenji
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316727765.17
282 rdf:type schema:Person
283 sg:person.01327061620.05 schema:affiliation grid-institutes:None
284 schema:familyName Higashikata
285 schema:givenName Toshinori
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327061620.05
287 rdf:type schema:Person
288 sg:person.01345026327.98 schema:affiliation grid-institutes:grid.414830.a
289 schema:familyName Kanaya
290 schema:givenName Honin
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345026327.98
292 rdf:type schema:Person
293 sg:person.01362470722.15 schema:affiliation grid-institutes:grid.9707.9
294 schema:familyName Konno
295 schema:givenName Tetsuo
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362470722.15
297 rdf:type schema:Person
298 sg:person.013703114332.12 schema:affiliation grid-institutes:None
299 schema:familyName Ueda
300 schema:givenName Kosei
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013703114332.12
302 rdf:type schema:Person
303 sg:person.01371020747.98 schema:affiliation grid-institutes:None
304 schema:familyName Nitta
305 schema:givenName Yutaka
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371020747.98
307 rdf:type schema:Person
308 sg:person.015312374614.34 schema:affiliation grid-institutes:grid.415492.f
309 schema:familyName Okeie
310 schema:givenName Kazuyasu
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015312374614.34
312 rdf:type schema:Person
313 sg:person.0607233257.95 schema:affiliation grid-institutes:grid.9707.9
314 schema:familyName Gamou
315 schema:givenName Tadatsugu
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607233257.95
317 rdf:type schema:Person
318 sg:person.0650607067.51 schema:affiliation grid-institutes:None
319 schema:familyName Hirase
320 schema:givenName Hiroaki
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650607067.51
322 rdf:type schema:Person
323 sg:person.0732262025.70 schema:affiliation grid-institutes:grid.417368.f
324 schema:familyName Michishita
325 schema:givenName Ichiro
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70
327 rdf:type schema:Person
328 sg:person.0762321530.31 schema:affiliation grid-institutes:grid.9707.9
329 schema:familyName Hayashi
330 schema:givenName Kenshi
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762321530.31
332 rdf:type schema:Person
333 sg:person.0770006522.11 schema:affiliation grid-institutes:grid.9707.9
334 schema:familyName Kawashiri
335 schema:givenName Masa-aki
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770006522.11
337 rdf:type schema:Person
338 sg:person.0773063461.71 schema:affiliation grid-institutes:None
339 schema:familyName Katsuda
340 schema:givenName Shoji
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773063461.71
342 rdf:type schema:Person
343 sg:person.0775364574.73 schema:affiliation grid-institutes:grid.418045.c
344 schema:familyName Mizuno
345 schema:givenName Sumio
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775364574.73
347 rdf:type schema:Person
348 sg:pub.10.1007/s00380-013-0453-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043153415
349 https://doi.org/10.1007/s00380-013-0453-8
350 rdf:type schema:CreativeWork
351 sg:pub.10.1007/s00380-014-0468-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025801560
352 https://doi.org/10.1007/s00380-014-0468-9
353 rdf:type schema:CreativeWork
354 sg:pub.10.1007/s00380-014-0522-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032907056
355 https://doi.org/10.1007/s00380-014-0522-7
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/hr.2013.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041803518
358 https://doi.org/10.1038/hr.2013.80
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/hr.2014.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044401479
361 https://doi.org/10.1038/hr.2014.20
362 rdf:type schema:CreativeWork
363 grid-institutes:None schema:alternateName Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
364 Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan
365 Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan
366 Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan
367 schema:name Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
368 Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan
369 Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan
370 Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan
371 rdf:type schema:Organization
372 grid-institutes:grid.414830.a schema:alternateName Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
373 schema:name Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
374 rdf:type schema:Organization
375 grid-institutes:grid.415492.f schema:alternateName Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan
376 schema:name Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan
377 rdf:type schema:Organization
378 grid-institutes:grid.417368.f schema:alternateName Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan
379 schema:name Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan
380 rdf:type schema:Organization
381 grid-institutes:grid.418045.c schema:alternateName Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan
382 schema:name Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan
383 rdf:type schema:Organization
384 grid-institutes:grid.9707.9 schema:alternateName Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan
385 Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
386 schema:name Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan
387 Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
388 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...