Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10-31

AUTHORS

Masa-aki Kawashiri, Kenji Sakata, Kenshi Hayashi, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Hidekazu Ino, Keisuke Nagase, Masakazu Yamagishi, Behalf of the MILLION Study Group

ABSTRACT

The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD. More... »

PAGES

539-548

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0910-2

DOI

http://dx.doi.org/10.1007/s00380-016-0910-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003156526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27798731


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