T wave amplitude in lead aVR as a novel diagnostic marker for cardiac sarcoidosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-27

AUTHORS

Yoshihiro Tanaka, Tetsuo Konno, Shohei Yoshida, Toyonobu Tsuda, Kenji Sakata, Hiroshi Furusho, Masayuki Takamura, Kenichi Yoshimura, Masakazu Yamagishi, Kenshi Hayashi

ABSTRACT

It is vital to identify cardiac involvement (CI) in patients with sarcoidosis as the condition could initially lead to sudden cardiac death. Although the T wave amplitude in lead aVR (TWAaVR) is reportedly associated with adverse cardiac events in various cardiovascular diseases, only scarce data are available concerning the utility of lead aVR in identifying CI in patients with sarcoidosis. We retrospectively investigated the diagnostic values of TWAaVR in patients with sarcoidosis in comparison with conventional electrocardiography parameters such as bundle branch block (BBB). From January 2006 to December 2014, 93 consecutive patients with sarcoidosis were enrolled (mean age, 55.7 ± 15.7 years; male, 31 %; cardiac involvement, n = 26). TWAaVR showed the greatest sensitivity (39 %) and specificity (92 %) in distinguishing between sarcoidosis patients with and without CI, at a cutoff value of −0.08 mV. The diagnostic value of BBB for cardiac involvement was significantly improved when combined with TWAaVR (sensitivity: 61–94 %, specificity: 97–89 %, area under the curve: 0.79–0.92, p = 0.018). Multivariate logistic regression analysis indicated that TWAaVR and BBB were independent electrocardiography parameters associated with CI. In summary, we observed that sarcoidosis patients exhibiting a high TWAaVR were likely to have CI. Thus, the application of a combination of BBB with TWAaVR may be useful when screening for CI in sarcoidosis patients. More... »

PAGES

352-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0881-3

DOI

http://dx.doi.org/10.1007/s00380-016-0881-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013668870

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27465594


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34 schema:description It is vital to identify cardiac involvement (CI) in patients with sarcoidosis as the condition could initially lead to sudden cardiac death. Although the T wave amplitude in lead aVR (TWAaVR) is reportedly associated with adverse cardiac events in various cardiovascular diseases, only scarce data are available concerning the utility of lead aVR in identifying CI in patients with sarcoidosis. We retrospectively investigated the diagnostic values of TWAaVR in patients with sarcoidosis in comparison with conventional electrocardiography parameters such as bundle branch block (BBB). From January 2006 to December 2014, 93 consecutive patients with sarcoidosis were enrolled (mean age, 55.7 ± 15.7 years; male, 31 %; cardiac involvement, n = 26). TWAaVR showed the greatest sensitivity (39 %) and specificity (92 %) in distinguishing between sarcoidosis patients with and without CI, at a cutoff value of −0.08 mV. The diagnostic value of BBB for cardiac involvement was significantly improved when combined with TWAaVR (sensitivity: 61–94 %, specificity: 97–89 %, area under the curve: 0.79–0.92, p = 0.018). Multivariate logistic regression analysis indicated that TWAaVR and BBB were independent electrocardiography parameters associated with CI. In summary, we observed that sarcoidosis patients exhibiting a high TWAaVR were likely to have CI. Thus, the application of a combination of BBB with TWAaVR may be useful when screening for CI in sarcoidosis patients.
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41 T-wave amplitude
42 adverse cardiac events
43 amplitude
44 analysis
45 applications
46 block
47 branch block
48 bundle branch block
49 cardiac death
50 cardiac events
51 cardiac involvement
52 cardiac sarcoidosis
53 cardiovascular disease
54 combination
55 comparison
56 conditions
57 consecutive patients
58 cutoff value
59 data
60 death
61 diagnostic marker
62 diagnostic value
63 disease
64 electrocardiography parameters
65 events
66 greater sensitivity
67 involvement
68 lead aVR
69 logistic regression analysis
70 markers
71 multivariate logistic regression analysis
72 novel diagnostic marker
73 parameters
74 patients
75 regression analysis
76 sarcoidosis
77 sarcoidosis patients
78 scarce data
79 sensitivity
80 specificity
81 sudden cardiac death
82 summary
83 utility
84 values
85 wave amplitude
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