Aliskiren suppresses atrial electrical and structural remodeling in a canine model of atrial fibrillation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-11

AUTHORS

Akira Satoh, Shinichi Niwano, Hiroe Niwano, Jun Kishihara, Yuya Aoyama, Jun Oikawa, Hidehira Fukaya, Hideaki Tamaki, Junya Ako

ABSTRACT

Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin–angiotensin system. We evaluated the effect of aliskiren on the electrical and structural remodeling in a canine atrial fibrillation (AF) model. Twenty-eight dogs were divided into three groups: (1) pacing control group (n = 12), with continuous atrial rapid pacing for 3 or 6 weeks, (2) pacing + aliskiren group (n = 12), with oral aliskiren (30 mg/kg/day), and (3) sham group (n = 4), no pacing nor drug administration. Electrophysiological properties and AF inducibility were evaluated every week. After the protocol, the left atrial tissue was sampled for the further histological and mRNA analysis. The electrical remodeling, AF inducibility, the left atrial enlargement and interstitial fibrosis were observed in pacing control group and were more prominent in the 6-week protocol (vs. 3 week, p < 0.05). The mRNA expressions of matricellular proteins exhibited upregulation in 3-week pacing control, but these upregulations became insignificant in 6 weeks. In contrast, collagen type 3 exhibited significant upregulation in 6 week but not in 3-week protocol. These changes were suppressed in the pacing + aliskiren group. Aliskiren suppressed the atrial remodeling in a canine AF model. This effect was accompanied by the suppression of tissue fibrosis. More... »

PAGES

90-100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0874-2

DOI

http://dx.doi.org/10.1007/s00380-016-0874-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037314934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27401739


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Fibrillation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiac Pacing, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fumarates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Atria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin-Angiotensin System", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satoh", 
        "givenName": "Akira", 
        "id": "sg:person.01160217040.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160217040.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niwano", 
        "givenName": "Shinichi", 
        "id": "sg:person.01252006200.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252006200.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Education, Tamagawa University, College of Education, Machida, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412905.b", 
          "name": [
            "Department of Education, Tamagawa University, College of Education, Machida, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niwano", 
        "givenName": "Hiroe", 
        "id": "sg:person.01173657551.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173657551.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishihara", 
        "givenName": "Jun", 
        "id": "sg:person.0606114254.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606114254.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoyama", 
        "givenName": "Yuya", 
        "id": "sg:person.01310106151.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310106151.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oikawa", 
        "givenName": "Jun", 
        "id": "sg:person.0623015640.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623015640.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukaya", 
        "givenName": "Hidehira", 
        "id": "sg:person.01261313360.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261313360.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamaki", 
        "givenName": "Hideaki", 
        "id": "sg:person.010642146241.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642146241.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ako", 
        "givenName": "Junya", 
        "id": "sg:person.0744472011.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744472011.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00380-015-0718-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016940092", 
          "https://doi.org/10.1007/s00380-015-0718-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-016-0853-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034481324", 
          "https://doi.org/10.1007/s00380-016-0853-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-011-0206-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017386439", 
          "https://doi.org/10.1007/s00395-011-0206-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1542-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050556439", 
          "https://doi.org/10.1007/s00125-004-1542-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-015-0719-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040134302", 
          "https://doi.org/10.1007/s00380-015-0719-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-014-6509-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021564406", 
          "https://doi.org/10.1007/s10557-014-6509-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07-11", 
    "datePublishedReg": "2016-07-11", 
    "description": "Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin\u2013angiotensin system. We evaluated the effect of aliskiren on the electrical and structural remodeling in a canine atrial fibrillation (AF) model. Twenty-eight dogs were divided into three groups: (1) pacing control group (n\u00a0=\u00a012), with continuous atrial rapid pacing for 3 or 6\u00a0weeks, (2) pacing\u00a0+\u00a0aliskiren group (n\u00a0=\u00a012), with oral aliskiren (30\u00a0mg/kg/day), and (3) sham group (n\u00a0=\u00a04), no pacing nor drug administration. Electrophysiological properties and AF inducibility were evaluated every week. After the protocol, the left atrial tissue was sampled for the further histological and mRNA analysis. The electrical remodeling, AF inducibility, the left atrial enlargement and interstitial fibrosis were observed in pacing control group and were more prominent in the 6-week protocol (vs. 3\u00a0week, p\u00a0<\u00a00.05). The mRNA expressions of matricellular proteins exhibited upregulation in 3-week pacing control, but these upregulations became insignificant in 6\u00a0weeks. In contrast, collagen type 3 exhibited significant upregulation in 6\u00a0week but not in 3-week protocol. These changes were suppressed in the pacing\u00a0+\u00a0aliskiren group. Aliskiren suppressed the atrial remodeling in a canine AF model. This effect was accompanied by the suppression of tissue fibrosis.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00380-016-0874-2", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6071915", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "keywords": [
      "aliskiren group", 
      "AF inducibility", 
      "structural remodeling", 
      "control group", 
      "effects of aliskiren", 
      "renin-angiotensin system", 
      "direct renin inhibitor", 
      "canine atrial fibrillation (AF) model", 
      "left atrial enlargement", 
      "left atrial tissue", 
      "canine AF model", 
      "atrial fibrillation model", 
      "oral aliskiren", 
      "atrial enlargement", 
      "atrial remodeling", 
      "sham group", 
      "interstitial fibrosis", 
      "atrial fibrillation", 
      "electrical remodeling", 
      "collagen type 3", 
      "atrial tissue", 
      "tissue fibrosis", 
      "Drug Administration", 
      "aliskiren", 
      "renin inhibitors", 
      "canine model", 
      "electrophysiological properties", 
      "mRNA expression", 
      "significant upregulation", 
      "matricellular protein", 
      "weeks", 
      "fibrillation model", 
      "type 3", 
      "remodeling", 
      "upregulation", 
      "mRNA analysis", 
      "fibrosis", 
      "AF model", 
      "group", 
      "inducibility", 
      "fibrillation", 
      "suppression", 
      "pacing", 
      "sufficient suppression", 
      "administration", 
      "dogs", 
      "protocol", 
      "inhibitors", 
      "enlargement", 
      "tissue", 
      "effect", 
      "expression", 
      "control", 
      "protein", 
      "contrast", 
      "changes", 
      "model", 
      "analysis", 
      "system", 
      "properties"
    ], 
    "name": "Aliskiren suppresses atrial electrical and structural remodeling in a canine model of atrial fibrillation", 
    "pagination": "90-100", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037314934"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00380-016-0874-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27401739"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00380-016-0874-2", 
      "https://app.dimensions.ai/details/publication/pub.1037314934"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_720.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00380-016-0874-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0874-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0874-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0874-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-016-0874-2'


 

This table displays all metadata directly associated to this object as RDF triples.

268 TRIPLES      21 PREDICATES      106 URIs      92 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00380-016-0874-2 schema:about N04e6913534ab4a6fbad3a67423f0e862
2 N0cbb93fb34d44e1dab781cb1a9ae4deb
3 N237a07e1a709409188b4e51a3ad1ebb7
4 N4b8d7b41dc3b4572852d21c8e8ee53b4
5 N4d8c677402654ddb94aad576384b63b4
6 N4f9074f282944b1d975eca6a381aab4f
7 N75b18cb053034815a3efc79e706550fd
8 N8d3d89d6a89949cb97a97fbc708bd8a9
9 N8da95cb5bc7645d28b41badee58ff617
10 N950bc20f443d4cd6b8deb91536269fea
11 Naddb7194286c4ba1b7dba4740ca00af9
12 Nbf6b5a8069754f618e06bafdd9d3d184
13 Nd758386b48f84c66a0efa447ac425397
14 Ne7502621a06e4e33b4b71a8cb5687697
15 Nf8dd131ac0944e3c8c4a8cc9a8f69dd3
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author N09bde613343648a497d7abb3477c544d
19 schema:citation sg:pub.10.1007/s00125-004-1542-0
20 sg:pub.10.1007/s00380-015-0718-5
21 sg:pub.10.1007/s00380-015-0719-4
22 sg:pub.10.1007/s00380-016-0853-7
23 sg:pub.10.1007/s00395-011-0206-8
24 sg:pub.10.1007/s10557-014-6509-x
25 schema:datePublished 2016-07-11
26 schema:datePublishedReg 2016-07-11
27 schema:description Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin–angiotensin system. We evaluated the effect of aliskiren on the electrical and structural remodeling in a canine atrial fibrillation (AF) model. Twenty-eight dogs were divided into three groups: (1) pacing control group (n = 12), with continuous atrial rapid pacing for 3 or 6 weeks, (2) pacing + aliskiren group (n = 12), with oral aliskiren (30 mg/kg/day), and (3) sham group (n = 4), no pacing nor drug administration. Electrophysiological properties and AF inducibility were evaluated every week. After the protocol, the left atrial tissue was sampled for the further histological and mRNA analysis. The electrical remodeling, AF inducibility, the left atrial enlargement and interstitial fibrosis were observed in pacing control group and were more prominent in the 6-week protocol (vs. 3 week, p < 0.05). The mRNA expressions of matricellular proteins exhibited upregulation in 3-week pacing control, but these upregulations became insignificant in 6 weeks. In contrast, collagen type 3 exhibited significant upregulation in 6 week but not in 3-week protocol. These changes were suppressed in the pacing + aliskiren group. Aliskiren suppressed the atrial remodeling in a canine AF model. This effect was accompanied by the suppression of tissue fibrosis.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N97a12d36249a41659c926539e69b89f2
31 Nb661607189ac4e6ca8910ed852920e09
32 sg:journal.1095887
33 schema:keywords AF inducibility
34 AF model
35 Drug Administration
36 administration
37 aliskiren
38 aliskiren group
39 analysis
40 atrial enlargement
41 atrial fibrillation
42 atrial fibrillation model
43 atrial remodeling
44 atrial tissue
45 canine AF model
46 canine atrial fibrillation (AF) model
47 canine model
48 changes
49 collagen type 3
50 contrast
51 control
52 control group
53 direct renin inhibitor
54 dogs
55 effect
56 effects of aliskiren
57 electrical remodeling
58 electrophysiological properties
59 enlargement
60 expression
61 fibrillation
62 fibrillation model
63 fibrosis
64 group
65 inducibility
66 inhibitors
67 interstitial fibrosis
68 left atrial enlargement
69 left atrial tissue
70 mRNA analysis
71 mRNA expression
72 matricellular protein
73 model
74 oral aliskiren
75 pacing
76 properties
77 protein
78 protocol
79 remodeling
80 renin inhibitors
81 renin-angiotensin system
82 sham group
83 significant upregulation
84 structural remodeling
85 sufficient suppression
86 suppression
87 system
88 tissue
89 tissue fibrosis
90 type 3
91 upregulation
92 weeks
93 schema:name Aliskiren suppresses atrial electrical and structural remodeling in a canine model of atrial fibrillation
94 schema:pagination 90-100
95 schema:productId N447dbdd26fb7439d9376bd1fa42b4023
96 N8359b42f7f6b4f2286603d6c4b3d0269
97 N9226d15e3af34a6f89ba545c8bb2ab88
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037314934
99 https://doi.org/10.1007/s00380-016-0874-2
100 schema:sdDatePublished 2022-09-02T16:01
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher Nc7e35b0469f74fcbb392d794585385d5
103 schema:url https://doi.org/10.1007/s00380-016-0874-2
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N04e6913534ab4a6fbad3a67423f0e862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Gene Expression
109 rdf:type schema:DefinedTerm
110 N09bde613343648a497d7abb3477c544d rdf:first sg:person.01160217040.44
111 rdf:rest N4ec7ec541daf4b32b5ac9b80e1735a01
112 N0cbb93fb34d44e1dab781cb1a9ae4deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Heart Atria
114 rdf:type schema:DefinedTerm
115 N1b26eec96c3f486f8d5ffad61ab4b82e rdf:first sg:person.0744472011.56
116 rdf:rest rdf:nil
117 N237a07e1a709409188b4e51a3ad1ebb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Animals
119 rdf:type schema:DefinedTerm
120 N31570665bb274df7bc479de291b15e89 rdf:first sg:person.0623015640.52
121 rdf:rest Nc034828a786242b884791567573321b1
122 N3ade65d9557646adba28e579f7aaba47 rdf:first sg:person.010642146241.84
123 rdf:rest N1b26eec96c3f486f8d5ffad61ab4b82e
124 N447dbdd26fb7439d9376bd1fa42b4023 schema:name dimensions_id
125 schema:value pub.1037314934
126 rdf:type schema:PropertyValue
127 N4b8d7b41dc3b4572852d21c8e8ee53b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Echocardiography
129 rdf:type schema:DefinedTerm
130 N4d8c677402654ddb94aad576384b63b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 N4ec7ec541daf4b32b5ac9b80e1735a01 rdf:first sg:person.01252006200.90
134 rdf:rest Nf5e40effeb99461eacaf980e5141e2df
135 N4f9074f282944b1d975eca6a381aab4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Fumarates
137 rdf:type schema:DefinedTerm
138 N75b18cb053034815a3efc79e706550fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Dogs
140 rdf:type schema:DefinedTerm
141 N8359b42f7f6b4f2286603d6c4b3d0269 schema:name doi
142 schema:value 10.1007/s00380-016-0874-2
143 rdf:type schema:PropertyValue
144 N8d3d89d6a89949cb97a97fbc708bd8a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Amides
146 rdf:type schema:DefinedTerm
147 N8da95cb5bc7645d28b41badee58ff617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Fibrosis
149 rdf:type schema:DefinedTerm
150 N9226d15e3af34a6f89ba545c8bb2ab88 schema:name pubmed_id
151 schema:value 27401739
152 rdf:type schema:PropertyValue
153 N950bc20f443d4cd6b8deb91536269fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Atrial Fibrillation
155 rdf:type schema:DefinedTerm
156 N97a12d36249a41659c926539e69b89f2 schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 Naddb7194286c4ba1b7dba4740ca00af9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Hemodynamics
160 rdf:type schema:DefinedTerm
161 Nb661607189ac4e6ca8910ed852920e09 schema:volumeNumber 32
162 rdf:type schema:PublicationVolume
163 Nb7f8b086edf84c77a85ec7b13f02c2ae rdf:first sg:person.01310106151.89
164 rdf:rest N31570665bb274df7bc479de291b15e89
165 Nbf6b5a8069754f618e06bafdd9d3d184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Renin
167 rdf:type schema:DefinedTerm
168 Nc034828a786242b884791567573321b1 rdf:first sg:person.01261313360.25
169 rdf:rest N3ade65d9557646adba28e579f7aaba47
170 Nc7e35b0469f74fcbb392d794585385d5 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 Nd758386b48f84c66a0efa447ac425397 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Disease Models, Animal
174 rdf:type schema:DefinedTerm
175 Ne7502621a06e4e33b4b71a8cb5687697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Renin-Angiotensin System
177 rdf:type schema:DefinedTerm
178 Ne82cc15449fe46eda4bad00e4448ad7e rdf:first sg:person.0606114254.34
179 rdf:rest Nb7f8b086edf84c77a85ec7b13f02c2ae
180 Nf5e40effeb99461eacaf980e5141e2df rdf:first sg:person.01173657551.17
181 rdf:rest Ne82cc15449fe46eda4bad00e4448ad7e
182 Nf8dd131ac0944e3c8c4a8cc9a8f69dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Cardiac Pacing, Artificial
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
189 schema:name Cardiorespiratory Medicine and Haematology
190 rdf:type schema:DefinedTerm
191 sg:grant.6071915 http://pending.schema.org/fundedItem sg:pub.10.1007/s00380-016-0874-2
192 rdf:type schema:MonetaryGrant
193 sg:journal.1095887 schema:issn 0910-8327
194 1615-2573
195 schema:name Heart and Vessels
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.010642146241.84 schema:affiliation grid-institutes:grid.410786.c
199 schema:familyName Tamaki
200 schema:givenName Hideaki
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642146241.84
202 rdf:type schema:Person
203 sg:person.01160217040.44 schema:affiliation grid-institutes:grid.410786.c
204 schema:familyName Satoh
205 schema:givenName Akira
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160217040.44
207 rdf:type schema:Person
208 sg:person.01173657551.17 schema:affiliation grid-institutes:grid.412905.b
209 schema:familyName Niwano
210 schema:givenName Hiroe
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173657551.17
212 rdf:type schema:Person
213 sg:person.01252006200.90 schema:affiliation grid-institutes:grid.410786.c
214 schema:familyName Niwano
215 schema:givenName Shinichi
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252006200.90
217 rdf:type schema:Person
218 sg:person.01261313360.25 schema:affiliation grid-institutes:grid.410786.c
219 schema:familyName Fukaya
220 schema:givenName Hidehira
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261313360.25
222 rdf:type schema:Person
223 sg:person.01310106151.89 schema:affiliation grid-institutes:grid.410786.c
224 schema:familyName Aoyama
225 schema:givenName Yuya
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310106151.89
227 rdf:type schema:Person
228 sg:person.0606114254.34 schema:affiliation grid-institutes:grid.410786.c
229 schema:familyName Kishihara
230 schema:givenName Jun
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606114254.34
232 rdf:type schema:Person
233 sg:person.0623015640.52 schema:affiliation grid-institutes:grid.410786.c
234 schema:familyName Oikawa
235 schema:givenName Jun
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623015640.52
237 rdf:type schema:Person
238 sg:person.0744472011.56 schema:affiliation grid-institutes:grid.410786.c
239 schema:familyName Ako
240 schema:givenName Junya
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744472011.56
242 rdf:type schema:Person
243 sg:pub.10.1007/s00125-004-1542-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050556439
244 https://doi.org/10.1007/s00125-004-1542-0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s00380-015-0718-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016940092
247 https://doi.org/10.1007/s00380-015-0718-5
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s00380-015-0719-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134302
250 https://doi.org/10.1007/s00380-015-0719-4
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s00380-016-0853-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034481324
253 https://doi.org/10.1007/s00380-016-0853-7
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/s00395-011-0206-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017386439
256 https://doi.org/10.1007/s00395-011-0206-8
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/s10557-014-6509-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021564406
259 https://doi.org/10.1007/s10557-014-6509-x
260 rdf:type schema:CreativeWork
261 grid-institutes:grid.410786.c schema:alternateName Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan
262 Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan
263 schema:name Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan
264 Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0329, Sagamihara, Japan
265 rdf:type schema:Organization
266 grid-institutes:grid.412905.b schema:alternateName Department of Education, Tamagawa University, College of Education, Machida, Japan
267 schema:name Department of Education, Tamagawa University, College of Education, Machida, Japan
268 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...