Comparison of first- and second-generation drug-eluting stent efficacies for treating left main and/or three-vessel disease: a propensity matched study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03-02

AUTHORS

Norihiro Kobayashi, Yoshiaki Ito, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Hideyuki Takimura, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Takuro Takama, Hiroya Takafuji, Takashi Maruyama, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Toshiya Muramatsu

ABSTRACT

The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexity of coronary artery disease using synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Between April 2007 and December 2012, 341 patients with LM and/or 3VD were treated by percutaneous coronary intervention; 154 with first-generation DES and 137 with second-generation DES. After propensity matching, 101 patients remained in each group. The rate of target lesion revascularization (TLR) and major adverse cardiac event (MACE) were compared. TLR and MACE at 2 years were more common in the first- compared with second-generation DES group (TLR 19.8 vs. 8.9 %; p = 0.016, MACE 24.8 vs. 10.9 %; p = 0.008). In patients with low (0–22) and intermediate (23–32) SYNTAX scores, TLR and MACE tended to occur more often with first-generation DES group. In patients with high SYNTAX scores (≧33), TLR and MACE were significantly more common with first-generation DES group (TLR 29.0 vs. 11.1 %; p = 0.035, MACE 35.5 vs. 13.9 %; p = 0.034). Compared with first-generation DES, second-generation DES proved beneficial in reducing risk of TLR and MACE in patients with LM and/or 3VD, particularly among those with high SYNTAX scores (≧33). More... »

PAGES

1930-1942

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0824-z

DOI

http://dx.doi.org/10.1007/s00380-016-0824-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044540600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26936450


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    "description": "The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexity of coronary artery disease using synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) scores. Between April 2007 and December 2012, 341 patients with LM and/or 3VD were treated by percutaneous coronary intervention; 154 with first-generation DES and 137 with second-generation DES. After propensity matching, 101 patients remained in each group. The rate of target lesion revascularization (TLR) and major adverse cardiac event (MACE) were compared. TLR and MACE at 2\u00a0years were more common in the first- compared with second-generation DES group (TLR 19.8 vs. 8.9\u00a0%; p\u00a0=\u00a00.016, MACE 24.8 vs. 10.9\u00a0%; p\u00a0=\u00a00.008). In patients with low (0\u201322) and intermediate (23\u201332) SYNTAX scores, TLR and MACE tended to occur more often with first-generation DES group. In patients with high SYNTAX scores (\u226733), TLR and MACE were significantly more common with first-generation DES group (TLR 29.0 vs. 11.1\u00a0%; p\u00a0=\u00a00.035, MACE 35.5 vs. 13.9\u00a0%; p\u00a0=\u00a00.034). Compared with first-generation DES, second-generation DES proved beneficial in reducing risk of TLR and MACE in patients with LM and/or 3VD, particularly among those with high SYNTAX scores (\u226733).", 
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