Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10

AUTHORS

Shoji Fukuda, Yuji Nakamura, Koso Egi, Shunichiro Fujioka, Satoshi Nagasaka, Pham Ngoc Minh, Koji Toguchi, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Tetsuya Mizoue, Kenji Takazawa, Shigeru Hosaka, Atsushi Sugiyama

ABSTRACT

Direct vasodilator effects of nitroglycerin, nifedipine, cilnidipine and diltiazem on human skeletonized internal mammary artery graft harvested with ultrasonic scalpel were assessed in the presence of 0.1 or 0.2 µM of noradrenaline. Ring preparations were made of distal end section of the bypass grafts, and those dilated by acetylcholine were used for assessment. Each drug dilated the artery in a concentration-related manner (0.01-10 µM, n = 6 for each drug) with a potency of nitroglycerin > nifedipine = cilnidipine > diltiazem. These results indicate that nitroglycerin can be useful for treating internal mammary artery spasm, that clinical utility of diltiazem may not depend on its vasodilator effect on the bypass graft, and that cilnidipine as well as nifedipine will have anti-spastic action which is in the middle between those of nitroglycerine and diltiazem. More... »

PAGES

1681-1684

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-016-0797-y

DOI

http://dx.doi.org/10.1007/s00380-016-0797-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025737354

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26820407


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