A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Takayoshi Matsumura, Eisuke Amiya, Natsuko Tamura, Yasuhiro Maejima, Issei Komuro, Mitsuaki Isobe

ABSTRACT

Takayasu arteritis (TAK) is an acute and chronic vasculitis of unknown etiology. Recently, our group reported that SNP rs6871626 in the IL12B region had significant association with disease susceptibility to TAK. However, association of the SNP with clinical characteristics of TAK has yet to be determined. Therefore, we assessed whether this SNP was associated with TAK disease severity as represented by early onset and/or refractoriness to medical therapy. A total of 90 patients were genotyped for rs6871626 and their clinical charts were reviewed retrospectively. By examining the relationship between genotype and clinical profiles of patients, we found a strong association between the number of risk alleles and the frequency of severe cases as defined by (1) age at onset <20 years old, (2) steroid resistance, and/or (3) a relapse of disease [p = 0.03; odds ratio 3.75 (95 % confidence interval 1.13-13.5)]. Thus, our study points to potential diagnostic use of SNP rs6871626 for predicting disease severity of TAK, with the goal of genotyping-oriented therapy in the near future. More... »

PAGES

1016-1019

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-015-0661-5

DOI

http://dx.doi.org/10.1007/s00380-015-0661-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004283916

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25783557


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