Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06-04

AUTHORS

Masa-aki Kawashiri, Kenji Sakata, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Kenshi Hayashi, Hidekazu Ino, Keisuke Nagase, Mitsuyasu Terashima, Masakazu Yamagishi

ABSTRACT

A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major cardiovascular events in patients with hypertension compared with an atenolol-based regimen. An open-label randomized multicenter study is primarily planned to evaluate the changes in coronary atheroma volume using intravascular ultrasonography 18–24 months after intensive lowering of LDL-cholesterol and blood pressure compared with a standard therapy indicated by current guidelines in Japanese patients with coronary artery disease (CAD). The secondary endpoints include changes in serum lipid levels, inflammatory markers, glucose markers and blood pressure. In total, 100 subjects with CAD who are undergoing percutaneous coronary intervention will be tested. The MILLION study will provide new evidence and therapeutic standards for the prevention of CAD in Japanese patients by controlling both LDL-C levels and blood pressure. More... »

PAGES

580-586

Journal

TITLE

Heart and Vessels

ISSUE

5

VOLUME

30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-014-0522-7

DOI

http://dx.doi.org/10.1007/s00380-014-0522-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032907056

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24895097


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371 Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan
372 Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan
373 schema:name Cardiovascular Imaging Center, Toyohashi, Japan
374 Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
375 Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan
376 Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan
377 Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan
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379 grid-institutes:grid.414830.a schema:alternateName Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
380 schema:name Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
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385 grid-institutes:grid.417368.f schema:alternateName Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan
386 schema:name Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan
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388 grid-institutes:grid.418045.c schema:alternateName Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan
389 schema:name Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan
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391 grid-institutes:grid.9707.9 schema:alternateName Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan
392 Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
393 schema:name Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan
394 Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
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