Response of urinary liver-type fatty acid-binding protein to contrast media administration has a potential to predict one-year renal outcome in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02-20

AUTHORS

Daishi Fujita, Masao Takahashi, Kent Doi, Mitsuru Abe, Junichi Tazaki, Arihiro Kiyosue, Masahiro Myojo, Jiro Ando, Hideo Fujita, Eisei Noiri, Takeshi Sugaya, Yasunobu Hirata, Issei Komuro

ABSTRACT

Urinary liver-type fatty acid-binding proteins (uL-FABP) have recently been recognized as a useful biomarker for predicting contrast-induced nephropathy. Although accumulating studies have evaluated short-term outcomes, its prognostic value for long-term renal prognosis in patients undergoing coronary angiography (CAG) has not been fully examined. This study aimed to evaluate the predictive value of uL-FABP for long-term renal outcome in patients with ischemic heart disease (IHD). Consecutive 24 patients with impaired renal function (serum creatinine >1.2 mg/dL) who underwent CAG were enrolled. uL-FABP was measured before CAG, 24 and 48 h after CAG. The changes in estimated glomerular filtration rate (eGFR) throughout CAG and at 1 year later were compared with the uL-FABP levels. The patients with a greater decrease in eGFR 1 year later had higher uL-FABP levels at all points, but only the value at 48 h after CAG reached statistical significance (lower vs. higher decreased eGFR group, 4.61 ± 3.87 vs. 17.71 ± 12.96; P < 0.01). Measurement of uL-FABP at 48 h after CAG (48h-uL-FABP) showed better correlation with the change in eGFR (pre-CAG uL-FABP vs. 48h-uL-FABP: R = 0.27, P = 0.20 vs. R = 0.65, P < 0.01). Moreover, the high-pre and high-48h-uL-FABP group showed a significantly larger decrease in eGFR compared with the high-pre and low-48h-uL-FABP group (change in eGFR; 8.12 ± 4.06 vs. 1.25 ± 2.23 mL/min/1.73 m2, P < 0.01), although the baseline eGFR levels were similar between these two groups. In this pilot study, measurement of uL-FABP levels at 48 h after CAG may be useful in detecting renal damage, and in predicting 1-year renal outcome in IHD patients undergoing CAG. More... »

PAGES

296-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-014-0484-9

DOI

http://dx.doi.org/10.1007/s00380-014-0484-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029977390

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24554034


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28 schema:description Urinary liver-type fatty acid-binding proteins (uL-FABP) have recently been recognized as a useful biomarker for predicting contrast-induced nephropathy. Although accumulating studies have evaluated short-term outcomes, its prognostic value for long-term renal prognosis in patients undergoing coronary angiography (CAG) has not been fully examined. This study aimed to evaluate the predictive value of uL-FABP for long-term renal outcome in patients with ischemic heart disease (IHD). Consecutive 24 patients with impaired renal function (serum creatinine >1.2 mg/dL) who underwent CAG were enrolled. uL-FABP was measured before CAG, 24 and 48 h after CAG. The changes in estimated glomerular filtration rate (eGFR) throughout CAG and at 1 year later were compared with the uL-FABP levels. The patients with a greater decrease in eGFR 1 year later had higher uL-FABP levels at all points, but only the value at 48 h after CAG reached statistical significance (lower vs. higher decreased eGFR group, 4.61 ± 3.87 vs. 17.71 ± 12.96; P < 0.01). Measurement of uL-FABP at 48 h after CAG (48h-uL-FABP) showed better correlation with the change in eGFR (pre-CAG uL-FABP vs. 48h-uL-FABP: R = 0.27, P = 0.20 vs. R = 0.65, P < 0.01). Moreover, the high-pre and high-48h-uL-FABP group showed a significantly larger decrease in eGFR compared with the high-pre and low-48h-uL-FABP group (change in eGFR; 8.12 ± 4.06 vs. 1.25 ± 2.23 mL/min/1.73 m2, P < 0.01), although the baseline eGFR levels were similar between these two groups. In this pilot study, measurement of uL-FABP levels at 48 h after CAG may be useful in detecting renal damage, and in predicting 1-year renal outcome in IHD patients undergoing CAG.
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36 EGFR levels
37 EGFR-1
38 FABP
39 FABP group
40 FABP levels
41 IHD patients
42 acid-binding protein
43 administration
44 angiography
45 baseline eGFR level
46 biomarkers
47 changes
48 contrast-induced nephropathy
49 coronary angiography
50 correlation
51 damage
52 decrease
53 disease
54 fatty acid-binding protein
55 filtration rate
56 function
57 glomerular filtration rate
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59 greater decrease
60 group
61 heart disease
62 impaired renal function
63 ischemic heart disease
64 large decrease
65 levels
66 liver-type fatty acid-binding protein
67 long-term renal outcome
68 long-term renal prognosis
69 measurements
70 medium administration
71 nephropathy
72 one-year renal outcome
73 outcomes
74 patients
75 pilot study
76 point
77 potential
78 predictive value
79 prognosis
80 prognostic value
81 protein
82 rate
83 renal damage
84 renal function
85 renal outcomes
86 renal prognosis
87 response
88 short-term outcomes
89 significance
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92 uL-FABP levels
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