Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-15

AUTHORS

Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

ABSTRACT

Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different. More... »

PAGES

36-44

Journal

TITLE

Heart and Vessels

ISSUE

1

VOLUME

30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8

DOI

http://dx.doi.org/10.1007/s00380-013-0453-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043153415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24337500


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Coronary Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pravastatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography, Interventional", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozue", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.01033145125.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Shingo", 
        "id": "sg:person.0701553335.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tohyama", 
        "givenName": "Shinichi", 
        "id": "sg:person.01263622125.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419708.3", 
          "name": [
            "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukui", 
        "givenName": "Kazuki", 
        "id": "sg:person.0650622624.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umezawa", 
        "givenName": "Shigeo", 
        "id": "sg:person.01202737502.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onishi", 
        "givenName": "Yuko", 
        "id": "sg:person.0765051224.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunishima", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.01155162765.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417369.e", 
          "name": [
            "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Akira", 
        "id": "sg:person.0717074353.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416698.4", 
          "name": [
            "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozato", 
        "givenName": "Toshihiro", 
        "id": "sg:person.0677360006.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Ebina General Hospital, Ebina, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459497.2", 
          "name": [
            "Department of Cardiology, Ebina General Hospital, Ebina, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyake", 
        "givenName": "Shogo", 
        "id": "sg:person.01215526224.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410714.7", 
          "name": [
            "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeyama", 
        "givenName": "Youichi", 
        "id": "sg:person.01270662323.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morino", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0746622734.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamauchi", 
        "givenName": "Takao", 
        "id": "sg:person.0726420725.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.461876.a", 
          "name": [
            "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Toshiya", 
        "id": "sg:person.01225552506.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibi", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01162702725.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Imaging Center, Toyohashi, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Cardiovascular Imaging Center, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terashima", 
        "givenName": "Mitsuyasu", 
        "id": "sg:person.0716062020.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michishita", 
        "givenName": "Ichiro", 
        "id": "sg:person.0732262025.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00380-013-0382-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007366485", 
          "https://doi.org/10.1007/s00380-013-0382-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-012-0236-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040113328", 
          "https://doi.org/10.1007/s00380-012-0236-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12-15", 
    "datePublishedReg": "2013-12-15", 
    "description": "Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00380-013-0453-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "thin-cap fibroatheroma", 
      "pathologic intimal thickening", 
      "virtual histology intravascular ultrasound", 
      "unstable angina pectoris", 
      "angina pectoris", 
      "effects of pitavastatin", 
      "plaque phenotype", 
      "intravascular ultrasound", 
      "statin therapy", 
      "VH-TCFA", 
      "VH-IVUS", 
      "stable angina pectoris", 
      "acute coronary syndrome", 
      "coronary artery plaques", 
      "effect of statins", 
      "nonculprit lesions", 
      "coronary syndrome", 
      "coronary atherosclerosis", 
      "artery plaques", 
      "intimal thickening", 
      "plaque rupture", 
      "vulnerable plaques", 
      "patients", 
      "statins", 
      "fibroatheroma", 
      "calcified plaques", 
      "pravastatin", 
      "pitavastatin", 
      "plaques", 
      "IVUS data", 
      "common type", 
      "therapy", 
      "ultrasound", 
      "phenotype", 
      "tissue characterization", 
      "rupture", 
      "pectoris", 
      "atherosclerosis", 
      "syndrome", 
      "lesions", 
      "baseline", 
      "months", 
      "effect", 
      "thickening", 
      "weak effect", 
      "only mechanism", 
      "conclusion", 
      "study", 
      "types", 
      "increase", 
      "contrast", 
      "strong effect", 
      "different types", 
      "mechanism", 
      "data", 
      "number", 
      "impact", 
      "comparison", 
      "precursors", 
      "formation", 
      "characterization", 
      "composition"
    ], 
    "name": "Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound", 
    "pagination": "36-44", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043153415"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00380-013-0453-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24337500"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00380-013-0453-8", 
      "https://app.dimensions.ai/details/publication/pub.1043153415"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_588.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00380-013-0453-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      22 PREDICATES      104 URIs      94 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00380-013-0453-8 schema:about N276dd05a71a74f8ca3a5fa2355f40384
2 N3d2acee85ba74506a1944ba491f0346f
3 N4378d6c585224d018dfbbd669e67edbe
4 N5b49c0fd54f9477587fc8d68cce3a9a8
5 N62aa7fec615a40e0b835d5b867c192a3
6 N8b19770444e449f3ae84a5a9439fab80
7 N8bbf9c9a17f641aca10694893733e930
8 N9ab4612a26de469eab4bce81d5fc38c7
9 Nb4e51ed655c7494b8cb911ab81ea5faa
10 Nc22ac4ac92af40c4bae3e4d8e845543c
11 Nca6ce758defe48bfb84030416f75b8ad
12 Ncbf239e18c624feea12cf6a02c29c4d0
13 Nd747ed0affce4039a7529b75945875a1
14 Ne84024aaa847465087abc94a712350c7
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author Neefa6388d14d40c9a00b9f3682c90c6c
18 schema:citation sg:pub.10.1007/s00380-012-0236-7
19 sg:pub.10.1007/s00380-013-0382-6
20 schema:datePublished 2013-12-15
21 schema:datePublishedReg 2013-12-15
22 schema:description Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N9b4c83b1f283460985ee41936d950c15
27 Nbf7da514b8c743fdadfe49b9f7455a49
28 sg:journal.1095887
29 schema:keywords IVUS data
30 VH-IVUS
31 VH-TCFA
32 acute coronary syndrome
33 angina pectoris
34 artery plaques
35 atherosclerosis
36 baseline
37 calcified plaques
38 characterization
39 common type
40 comparison
41 composition
42 conclusion
43 contrast
44 coronary artery plaques
45 coronary atherosclerosis
46 coronary syndrome
47 data
48 different types
49 effect
50 effect of statins
51 effects of pitavastatin
52 fibroatheroma
53 formation
54 impact
55 increase
56 intimal thickening
57 intravascular ultrasound
58 lesions
59 mechanism
60 months
61 nonculprit lesions
62 number
63 only mechanism
64 pathologic intimal thickening
65 patients
66 pectoris
67 phenotype
68 pitavastatin
69 plaque phenotype
70 plaque rupture
71 plaques
72 pravastatin
73 precursors
74 rupture
75 stable angina pectoris
76 statin therapy
77 statins
78 strong effect
79 study
80 syndrome
81 therapy
82 thickening
83 thin-cap fibroatheroma
84 tissue characterization
85 types
86 ultrasound
87 unstable angina pectoris
88 virtual histology intravascular ultrasound
89 vulnerable plaques
90 weak effect
91 schema:name Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound
92 schema:pagination 36-44
93 schema:productId N318852c32aba4cfcbb8e809a6ad8177d
94 N70c652d9f79e44de8af4e8eec228582e
95 N74bcbaf113eb4ce08ab298e0afdbc3cf
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043153415
97 https://doi.org/10.1007/s00380-013-0453-8
98 schema:sdDatePublished 2022-05-20T07:28
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N72373c1a00bb4143aac1645c94e9b10e
101 schema:url https://doi.org/10.1007/s00380-013-0453-8
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0a22ef9f3a984579abbf4e35e779d105 rdf:first sg:person.01215526224.39
106 rdf:rest N9c826fbf87de4c8ba889dbca385fd2fe
107 N16780f7a54d4467db862b1740e09ae60 rdf:first sg:person.0716062020.45
108 rdf:rest N4d3b2bc5268a4a71ab97d3e4cdec49cd
109 N22a11a7550f34817856fbfb8d02afe5d rdf:first sg:person.0717074353.90
110 rdf:rest N70ea274ea57248a7843fb8cb78f2aa20
111 N276dd05a71a74f8ca3a5fa2355f40384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N318852c32aba4cfcbb8e809a6ad8177d schema:name pubmed_id
115 schema:value 24337500
116 rdf:type schema:PropertyValue
117 N3d2acee85ba74506a1944ba491f0346f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Necrosis
119 rdf:type schema:DefinedTerm
120 N4378d6c585224d018dfbbd669e67edbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Coronary Artery Disease
122 rdf:type schema:DefinedTerm
123 N4d3b2bc5268a4a71ab97d3e4cdec49cd rdf:first sg:person.0732262025.70
124 rdf:rest rdf:nil
125 N4f0c7bcf95464a6380cd526e443a5e79 rdf:first sg:person.01263622125.63
126 rdf:rest N590bb3cea9d54a639a4ddc63a86c82dd
127 N547ade88f6b04b02b5e94d9394179dfd rdf:first sg:person.01162702725.19
128 rdf:rest N16780f7a54d4467db862b1740e09ae60
129 N590bb3cea9d54a639a4ddc63a86c82dd rdf:first sg:person.0650622624.12
130 rdf:rest Ne036b6ddebbd41148bbd11290c940060
131 N5b49c0fd54f9477587fc8d68cce3a9a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Prospective Studies
133 rdf:type schema:DefinedTerm
134 N5bcaea4bedd24f81be56bf8e5b188d5f rdf:first sg:person.01155162765.62
135 rdf:rest N22a11a7550f34817856fbfb8d02afe5d
136 N62aa7fec615a40e0b835d5b867c192a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Quinolines
138 rdf:type schema:DefinedTerm
139 N70c652d9f79e44de8af4e8eec228582e schema:name doi
140 schema:value 10.1007/s00380-013-0453-8
141 rdf:type schema:PropertyValue
142 N70ea274ea57248a7843fb8cb78f2aa20 rdf:first sg:person.0677360006.66
143 rdf:rest N0a22ef9f3a984579abbf4e35e779d105
144 N72373c1a00bb4143aac1645c94e9b10e schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N74118473af064f0a80999cb272c813d6 rdf:first sg:person.0765051224.75
147 rdf:rest N5bcaea4bedd24f81be56bf8e5b188d5f
148 N74bcbaf113eb4ce08ab298e0afdbc3cf schema:name dimensions_id
149 schema:value pub.1043153415
150 rdf:type schema:PropertyValue
151 N84299f5bcc2049bbb187673cef721559 rdf:first sg:person.0726420725.83
152 rdf:rest N8d71440dad02453b9896cb1e57d871f0
153 N89c868aac82e46e29c4d8b568d794677 rdf:first sg:person.0701553335.84
154 rdf:rest N4f0c7bcf95464a6380cd526e443a5e79
155 N8b19770444e449f3ae84a5a9439fab80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Phenotype
157 rdf:type schema:DefinedTerm
158 N8bbf9c9a17f641aca10694893733e930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Pravastatin
160 rdf:type schema:DefinedTerm
161 N8d71440dad02453b9896cb1e57d871f0 rdf:first sg:person.01225552506.20
162 rdf:rest N547ade88f6b04b02b5e94d9394179dfd
163 N9ab4612a26de469eab4bce81d5fc38c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Middle Aged
165 rdf:type schema:DefinedTerm
166 N9b4c83b1f283460985ee41936d950c15 schema:volumeNumber 30
167 rdf:type schema:PublicationVolume
168 N9c826fbf87de4c8ba889dbca385fd2fe rdf:first sg:person.01270662323.35
169 rdf:rest Ne979cd3e7a13485486060229535a4240
170 Nb4e51ed655c7494b8cb911ab81ea5faa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Ultrasonography, Interventional
172 rdf:type schema:DefinedTerm
173 Nbf7da514b8c743fdadfe49b9f7455a49 schema:issueNumber 1
174 rdf:type schema:PublicationIssue
175 Nc22ac4ac92af40c4bae3e4d8e845543c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Plaque, Atherosclerotic
177 rdf:type schema:DefinedTerm
178 Nca6ce758defe48bfb84030416f75b8ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 Ncbf239e18c624feea12cf6a02c29c4d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Female
183 rdf:type schema:DefinedTerm
184 Nd747ed0affce4039a7529b75945875a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Acute Coronary Syndrome
186 rdf:type schema:DefinedTerm
187 Ne036b6ddebbd41148bbd11290c940060 rdf:first sg:person.01202737502.01
188 rdf:rest N74118473af064f0a80999cb272c813d6
189 Ne84024aaa847465087abc94a712350c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Ne979cd3e7a13485486060229535a4240 rdf:first sg:person.0746622734.07
193 rdf:rest N84299f5bcc2049bbb187673cef721559
194 Neefa6388d14d40c9a00b9f3682c90c6c rdf:first sg:person.01033145125.12
195 rdf:rest N89c868aac82e46e29c4d8b568d794677
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
200 schema:name Cardiorespiratory Medicine and Haematology
201 rdf:type schema:DefinedTerm
202 sg:journal.1095887 schema:issn 0910-8327
203 1615-2573
204 schema:name Heart and Vessels
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.01033145125.12 schema:affiliation grid-institutes:grid.417368.f
208 schema:familyName Nozue
209 schema:givenName Tsuyoshi
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12
211 rdf:type schema:Person
212 sg:person.01155162765.62 schema:affiliation grid-institutes:grid.264706.1
213 schema:familyName Kunishima
214 schema:givenName Tomoyuki
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62
216 rdf:type schema:Person
217 sg:person.01162702725.19 schema:affiliation grid-institutes:grid.413045.7
218 schema:familyName Hibi
219 schema:givenName Kiyoshi
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19
221 rdf:type schema:Person
222 sg:person.01202737502.01 schema:affiliation grid-institutes:grid.414150.5
223 schema:familyName Umezawa
224 schema:givenName Shigeo
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01
226 rdf:type schema:Person
227 sg:person.01215526224.39 schema:affiliation grid-institutes:grid.459497.2
228 schema:familyName Miyake
229 schema:givenName Shogo
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39
231 rdf:type schema:Person
232 sg:person.01225552506.20 schema:affiliation grid-institutes:grid.461876.a
233 schema:familyName Muramatsu
234 schema:givenName Toshiya
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20
236 rdf:type schema:Person
237 sg:person.01263622125.63 schema:affiliation grid-institutes:None
238 schema:familyName Tohyama
239 schema:givenName Shinichi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63
241 rdf:type schema:Person
242 sg:person.01270662323.35 schema:affiliation grid-institutes:grid.410714.7
243 schema:familyName Takeyama
244 schema:givenName Youichi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35
246 rdf:type schema:Person
247 sg:person.0650622624.12 schema:affiliation grid-institutes:grid.419708.3
248 schema:familyName Fukui
249 schema:givenName Kazuki
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12
251 rdf:type schema:Person
252 sg:person.0677360006.66 schema:affiliation grid-institutes:grid.416698.4
253 schema:familyName Nozato
254 schema:givenName Toshihiro
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66
256 rdf:type schema:Person
257 sg:person.0701553335.84 schema:affiliation grid-institutes:None
258 schema:familyName Yamamoto
259 schema:givenName Shingo
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84
261 rdf:type schema:Person
262 sg:person.0716062020.45 schema:affiliation grid-institutes:None
263 schema:familyName Terashima
264 schema:givenName Mitsuyasu
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45
266 rdf:type schema:Person
267 sg:person.0717074353.90 schema:affiliation grid-institutes:grid.417369.e
268 schema:familyName Sato
269 schema:givenName Akira
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90
271 rdf:type schema:Person
272 sg:person.0726420725.83 schema:affiliation grid-institutes:grid.410818.4
273 schema:familyName Yamauchi
274 schema:givenName Takao
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83
276 rdf:type schema:Person
277 sg:person.0732262025.70 schema:affiliation grid-institutes:grid.417368.f
278 schema:familyName Michishita
279 schema:givenName Ichiro
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70
281 rdf:type schema:Person
282 sg:person.0746622734.07 schema:affiliation grid-institutes:grid.265061.6
283 schema:familyName Morino
284 schema:givenName Yoshihiro
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07
286 rdf:type schema:Person
287 sg:person.0765051224.75 schema:affiliation grid-institutes:grid.414150.5
288 schema:familyName Onishi
289 schema:givenName Yuko
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75
291 rdf:type schema:Person
292 sg:pub.10.1007/s00380-012-0236-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040113328
293 https://doi.org/10.1007/s00380-012-0236-7
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/s00380-013-0382-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007366485
296 https://doi.org/10.1007/s00380-013-0382-6
297 rdf:type schema:CreativeWork
298 grid-institutes:None schema:alternateName Cardiovascular Imaging Center, Toyohashi, Japan
299 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
300 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
301 schema:name Cardiovascular Imaging Center, Toyohashi, Japan
302 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
303 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
304 rdf:type schema:Organization
305 grid-institutes:grid.264706.1 schema:alternateName Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
306 schema:name Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
307 rdf:type schema:Organization
308 grid-institutes:grid.265061.6 schema:alternateName Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
309 schema:name Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
310 rdf:type schema:Organization
311 grid-institutes:grid.410714.7 schema:alternateName Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
312 schema:name Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
313 rdf:type schema:Organization
314 grid-institutes:grid.410818.4 schema:alternateName Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
315 schema:name Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
316 rdf:type schema:Organization
317 grid-institutes:grid.413045.7 schema:alternateName Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
318 schema:name Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
319 rdf:type schema:Organization
320 grid-institutes:grid.414150.5 schema:alternateName Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
321 schema:name Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
322 rdf:type schema:Organization
323 grid-institutes:grid.416698.4 schema:alternateName Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
324 schema:name Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
325 rdf:type schema:Organization
326 grid-institutes:grid.417368.f schema:alternateName Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
327 schema:name Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
328 rdf:type schema:Organization
329 grid-institutes:grid.417369.e schema:alternateName Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
330 schema:name Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
331 rdf:type schema:Organization
332 grid-institutes:grid.419708.3 schema:alternateName Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
333 schema:name Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
334 rdf:type schema:Organization
335 grid-institutes:grid.459497.2 schema:alternateName Department of Cardiology, Ebina General Hospital, Ebina, Japan
336 schema:name Department of Cardiology, Ebina General Hospital, Ebina, Japan
337 rdf:type schema:Organization
338 grid-institutes:grid.461876.a schema:alternateName Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
339 schema:name Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...