Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-15

AUTHORS

Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

ABSTRACT

Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different. More... »

PAGES

36-44

Journal

TITLE

Heart and Vessels

ISSUE

1

VOLUME

30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8

DOI

http://dx.doi.org/10.1007/s00380-013-0453-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043153415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24337500


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Coronary Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pravastatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography, Interventional", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozue", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.01033145125.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Shingo", 
        "id": "sg:person.0701553335.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tohyama", 
        "givenName": "Shinichi", 
        "id": "sg:person.01263622125.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419708.3", 
          "name": [
            "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukui", 
        "givenName": "Kazuki", 
        "id": "sg:person.0650622624.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umezawa", 
        "givenName": "Shigeo", 
        "id": "sg:person.01202737502.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onishi", 
        "givenName": "Yuko", 
        "id": "sg:person.0765051224.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunishima", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.01155162765.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417369.e", 
          "name": [
            "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Akira", 
        "id": "sg:person.0717074353.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416698.4", 
          "name": [
            "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozato", 
        "givenName": "Toshihiro", 
        "id": "sg:person.0677360006.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Ebina General Hospital, Ebina, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459497.2", 
          "name": [
            "Department of Cardiology, Ebina General Hospital, Ebina, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyake", 
        "givenName": "Shogo", 
        "id": "sg:person.01215526224.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410714.7", 
          "name": [
            "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeyama", 
        "givenName": "Youichi", 
        "id": "sg:person.01270662323.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morino", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0746622734.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamauchi", 
        "givenName": "Takao", 
        "id": "sg:person.0726420725.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.461876.a", 
          "name": [
            "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Toshiya", 
        "id": "sg:person.01225552506.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibi", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01162702725.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Imaging Center, Toyohashi, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Cardiovascular Imaging Center, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terashima", 
        "givenName": "Mitsuyasu", 
        "id": "sg:person.0716062020.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michishita", 
        "givenName": "Ichiro", 
        "id": "sg:person.0732262025.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00380-013-0382-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007366485", 
          "https://doi.org/10.1007/s00380-013-0382-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-012-0236-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040113328", 
          "https://doi.org/10.1007/s00380-012-0236-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12-15", 
    "datePublishedReg": "2013-12-15", 
    "description": "Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00380-013-0453-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "thin-cap fibroatheroma", 
      "pathologic intimal thickening", 
      "virtual histology intravascular ultrasound", 
      "unstable angina pectoris", 
      "angina pectoris", 
      "effects of pitavastatin", 
      "plaque phenotype", 
      "intravascular ultrasound", 
      "statin therapy", 
      "VH-TCFA", 
      "VH-IVUS", 
      "stable angina pectoris", 
      "acute coronary syndrome", 
      "coronary artery plaques", 
      "effect of statins", 
      "nonculprit lesions", 
      "coronary syndrome", 
      "coronary atherosclerosis", 
      "artery plaques", 
      "intimal thickening", 
      "plaque rupture", 
      "vulnerable plaques", 
      "patients", 
      "statins", 
      "fibroatheroma", 
      "calcified plaques", 
      "pravastatin", 
      "pitavastatin", 
      "plaques", 
      "IVUS data", 
      "common type", 
      "therapy", 
      "ultrasound", 
      "phenotype", 
      "tissue characterization", 
      "rupture", 
      "pectoris", 
      "atherosclerosis", 
      "syndrome", 
      "lesions", 
      "baseline", 
      "months", 
      "effect", 
      "thickening", 
      "weak effect", 
      "only mechanism", 
      "conclusion", 
      "study", 
      "types", 
      "increase", 
      "contrast", 
      "strong effect", 
      "different types", 
      "mechanism", 
      "data", 
      "number", 
      "impact", 
      "comparison", 
      "precursors", 
      "formation", 
      "characterization", 
      "composition", 
      "coronary artery plaque phenotype", 
      "artery plaque phenotype", 
      "histology (VH) intravascular ultrasound", 
      "analyzable IVUS data", 
      "serial virtual histology intravascular ultrasound"
    ], 
    "name": "Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound", 
    "pagination": "36-44", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043153415"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00380-013-0453-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24337500"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00380-013-0453-8", 
      "https://app.dimensions.ai/details/publication/pub.1043153415"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00380-013-0453-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0453-8'


 

This table displays all metadata directly associated to this object as RDF triples.

345 TRIPLES      22 PREDICATES      109 URIs      99 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00380-013-0453-8 schema:about N16c23d429b0247a6861fcb79f6832aff
2 N1844eb9b0ea84a73a19290d34e108feb
3 N25b1caa35c0b4aeab9f579cf3d2efe9c
4 N434c444ef9904fe68fea8c9e3cc75377
5 N5d05b01c705049eca3cb66eb1a895bd6
6 N7308221fa69640e382e108b283551359
7 N83573c1bc4fd478289ba3bb9c16ad27e
8 N8449a5fd74aa499f998bde352b327cfa
9 N8d713b8ed4464be9acba5a5c99a5839d
10 Na7dc350f8ca643b186d72ce4f618cef2
11 Nad2c907df7e842cc8f61de6d86d195a1
12 Nb8162ab99fe148a9b2d09260fcedb0cd
13 Nd6a2bd563e0c4956b0a13f754abe9acc
14 Nde27fcc549eb4a438ea16089965ea028
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author Nf8e9bbd8dde34250b0c28695dee1e819
18 schema:citation sg:pub.10.1007/s00380-012-0236-7
19 sg:pub.10.1007/s00380-013-0382-6
20 schema:datePublished 2013-12-15
21 schema:datePublishedReg 2013-12-15
22 schema:description Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf Ndc3d496095164b90a85cc0dfc685d70a
27 Ne4669a015ab148e9873954eb2d88c2ba
28 sg:journal.1095887
29 schema:keywords IVUS data
30 VH-IVUS
31 VH-TCFA
32 acute coronary syndrome
33 analyzable IVUS data
34 angina pectoris
35 artery plaque phenotype
36 artery plaques
37 atherosclerosis
38 baseline
39 calcified plaques
40 characterization
41 common type
42 comparison
43 composition
44 conclusion
45 contrast
46 coronary artery plaque phenotype
47 coronary artery plaques
48 coronary atherosclerosis
49 coronary syndrome
50 data
51 different types
52 effect
53 effect of statins
54 effects of pitavastatin
55 fibroatheroma
56 formation
57 histology (VH) intravascular ultrasound
58 impact
59 increase
60 intimal thickening
61 intravascular ultrasound
62 lesions
63 mechanism
64 months
65 nonculprit lesions
66 number
67 only mechanism
68 pathologic intimal thickening
69 patients
70 pectoris
71 phenotype
72 pitavastatin
73 plaque phenotype
74 plaque rupture
75 plaques
76 pravastatin
77 precursors
78 rupture
79 serial virtual histology intravascular ultrasound
80 stable angina pectoris
81 statin therapy
82 statins
83 strong effect
84 study
85 syndrome
86 therapy
87 thickening
88 thin-cap fibroatheroma
89 tissue characterization
90 types
91 ultrasound
92 unstable angina pectoris
93 virtual histology intravascular ultrasound
94 vulnerable plaques
95 weak effect
96 schema:name Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound
97 schema:pagination 36-44
98 schema:productId N09edd80919ab4f8485fa6b31d24b1c16
99 Nc2dbe79aa1a448579a42ebeb65f170ef
100 Nd37df124dadf462ca033cb0dc79ef81f
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043153415
102 https://doi.org/10.1007/s00380-013-0453-8
103 schema:sdDatePublished 2022-01-01T18:30
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N0ed4bf0ff4ec477bb3b827e7b94adede
106 schema:url https://doi.org/10.1007/s00380-013-0453-8
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N09edd80919ab4f8485fa6b31d24b1c16 schema:name dimensions_id
111 schema:value pub.1043153415
112 rdf:type schema:PropertyValue
113 N0d639503f8c74871a093865748dd90c1 rdf:first sg:person.01162702725.19
114 rdf:rest N963e8764bf9b498b80e4c90711fc4052
115 N0ed4bf0ff4ec477bb3b827e7b94adede schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N15c3dfd116db4426968051e64d546974 rdf:first sg:person.01155162765.62
118 rdf:rest N90c8a492f3e04818b27c512ed7111218
119 N16c23d429b0247a6861fcb79f6832aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Acute Coronary Syndrome
121 rdf:type schema:DefinedTerm
122 N1844eb9b0ea84a73a19290d34e108feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Male
124 rdf:type schema:DefinedTerm
125 N1ad45c505d284d6faad6e41cc974dd55 rdf:first sg:person.0701553335.84
126 rdf:rest Ndbe47bb0d89c4d84aef5374fa90cadec
127 N1dfbd5e262ca4a8fa31a6e91392ea873 rdf:first sg:person.01215526224.39
128 rdf:rest N2fe3419769bb48e2af686bad09d51370
129 N25b1caa35c0b4aeab9f579cf3d2efe9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Phenotype
131 rdf:type schema:DefinedTerm
132 N2fe3419769bb48e2af686bad09d51370 rdf:first sg:person.01270662323.35
133 rdf:rest N6e79c2db84154f67943959cb33321719
134 N434c444ef9904fe68fea8c9e3cc75377 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Aged
136 rdf:type schema:DefinedTerm
137 N5d05b01c705049eca3cb66eb1a895bd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Coronary Artery Disease
139 rdf:type schema:DefinedTerm
140 N6d5c4aabb92a4da393d3f0b359c62623 rdf:first sg:person.0726420725.83
141 rdf:rest Ncd2e7b65b59f44dabb05b698046ab272
142 N6e79c2db84154f67943959cb33321719 rdf:first sg:person.0746622734.07
143 rdf:rest N6d5c4aabb92a4da393d3f0b359c62623
144 N7308221fa69640e382e108b283551359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Pravastatin
146 rdf:type schema:DefinedTerm
147 N756a5d53df5f48bb9a3811d6510db1cc rdf:first sg:person.0677360006.66
148 rdf:rest N1dfbd5e262ca4a8fa31a6e91392ea873
149 N83573c1bc4fd478289ba3bb9c16ad27e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 N8449a5fd74aa499f998bde352b327cfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Necrosis
154 rdf:type schema:DefinedTerm
155 N8d713b8ed4464be9acba5a5c99a5839d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Middle Aged
157 rdf:type schema:DefinedTerm
158 N90c8a492f3e04818b27c512ed7111218 rdf:first sg:person.0717074353.90
159 rdf:rest N756a5d53df5f48bb9a3811d6510db1cc
160 N963e8764bf9b498b80e4c90711fc4052 rdf:first sg:person.0716062020.45
161 rdf:rest Nb7a9461828e4400281faa66d0af371a3
162 N9833bc667d4b476f92aabb9430ab4397 rdf:first sg:person.0765051224.75
163 rdf:rest N15c3dfd116db4426968051e64d546974
164 Na4296d369dd340209c1e82b6761cc4a9 rdf:first sg:person.01202737502.01
165 rdf:rest N9833bc667d4b476f92aabb9430ab4397
166 Na7dc350f8ca643b186d72ce4f618cef2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Ultrasonography, Interventional
168 rdf:type schema:DefinedTerm
169 Nad2c907df7e842cc8f61de6d86d195a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Prospective Studies
171 rdf:type schema:DefinedTerm
172 Nb7a9461828e4400281faa66d0af371a3 rdf:first sg:person.0732262025.70
173 rdf:rest rdf:nil
174 Nb8162ab99fe148a9b2d09260fcedb0cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Female
176 rdf:type schema:DefinedTerm
177 Nc2dbe79aa1a448579a42ebeb65f170ef schema:name doi
178 schema:value 10.1007/s00380-013-0453-8
179 rdf:type schema:PropertyValue
180 Ncd2e7b65b59f44dabb05b698046ab272 rdf:first sg:person.01225552506.20
181 rdf:rest N0d639503f8c74871a093865748dd90c1
182 Nd37df124dadf462ca033cb0dc79ef81f schema:name pubmed_id
183 schema:value 24337500
184 rdf:type schema:PropertyValue
185 Nd6a2bd563e0c4956b0a13f754abe9acc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Plaque, Atherosclerotic
187 rdf:type schema:DefinedTerm
188 Ndbe47bb0d89c4d84aef5374fa90cadec rdf:first sg:person.01263622125.63
189 rdf:rest Nf0154444fabd4976b6b3ec184f50294f
190 Ndc3d496095164b90a85cc0dfc685d70a schema:volumeNumber 30
191 rdf:type schema:PublicationVolume
192 Nde27fcc549eb4a438ea16089965ea028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Quinolines
194 rdf:type schema:DefinedTerm
195 Ne4669a015ab148e9873954eb2d88c2ba schema:issueNumber 1
196 rdf:type schema:PublicationIssue
197 Nf0154444fabd4976b6b3ec184f50294f rdf:first sg:person.0650622624.12
198 rdf:rest Na4296d369dd340209c1e82b6761cc4a9
199 Nf8e9bbd8dde34250b0c28695dee1e819 rdf:first sg:person.01033145125.12
200 rdf:rest N1ad45c505d284d6faad6e41cc974dd55
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
205 schema:name Cardiorespiratory Medicine and Haematology
206 rdf:type schema:DefinedTerm
207 sg:journal.1095887 schema:issn 0910-8327
208 1615-2573
209 schema:name Heart and Vessels
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01033145125.12 schema:affiliation grid-institutes:grid.417368.f
213 schema:familyName Nozue
214 schema:givenName Tsuyoshi
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12
216 rdf:type schema:Person
217 sg:person.01155162765.62 schema:affiliation grid-institutes:grid.264706.1
218 schema:familyName Kunishima
219 schema:givenName Tomoyuki
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62
221 rdf:type schema:Person
222 sg:person.01162702725.19 schema:affiliation grid-institutes:grid.413045.7
223 schema:familyName Hibi
224 schema:givenName Kiyoshi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19
226 rdf:type schema:Person
227 sg:person.01202737502.01 schema:affiliation grid-institutes:grid.414150.5
228 schema:familyName Umezawa
229 schema:givenName Shigeo
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01
231 rdf:type schema:Person
232 sg:person.01215526224.39 schema:affiliation grid-institutes:grid.459497.2
233 schema:familyName Miyake
234 schema:givenName Shogo
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39
236 rdf:type schema:Person
237 sg:person.01225552506.20 schema:affiliation grid-institutes:grid.461876.a
238 schema:familyName Muramatsu
239 schema:givenName Toshiya
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20
241 rdf:type schema:Person
242 sg:person.01263622125.63 schema:affiliation grid-institutes:None
243 schema:familyName Tohyama
244 schema:givenName Shinichi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63
246 rdf:type schema:Person
247 sg:person.01270662323.35 schema:affiliation grid-institutes:grid.410714.7
248 schema:familyName Takeyama
249 schema:givenName Youichi
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35
251 rdf:type schema:Person
252 sg:person.0650622624.12 schema:affiliation grid-institutes:grid.419708.3
253 schema:familyName Fukui
254 schema:givenName Kazuki
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12
256 rdf:type schema:Person
257 sg:person.0677360006.66 schema:affiliation grid-institutes:grid.416698.4
258 schema:familyName Nozato
259 schema:givenName Toshihiro
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66
261 rdf:type schema:Person
262 sg:person.0701553335.84 schema:affiliation grid-institutes:None
263 schema:familyName Yamamoto
264 schema:givenName Shingo
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84
266 rdf:type schema:Person
267 sg:person.0716062020.45 schema:affiliation grid-institutes:None
268 schema:familyName Terashima
269 schema:givenName Mitsuyasu
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45
271 rdf:type schema:Person
272 sg:person.0717074353.90 schema:affiliation grid-institutes:grid.417369.e
273 schema:familyName Sato
274 schema:givenName Akira
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90
276 rdf:type schema:Person
277 sg:person.0726420725.83 schema:affiliation grid-institutes:grid.410818.4
278 schema:familyName Yamauchi
279 schema:givenName Takao
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83
281 rdf:type schema:Person
282 sg:person.0732262025.70 schema:affiliation grid-institutes:grid.417368.f
283 schema:familyName Michishita
284 schema:givenName Ichiro
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70
286 rdf:type schema:Person
287 sg:person.0746622734.07 schema:affiliation grid-institutes:grid.265061.6
288 schema:familyName Morino
289 schema:givenName Yoshihiro
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07
291 rdf:type schema:Person
292 sg:person.0765051224.75 schema:affiliation grid-institutes:grid.414150.5
293 schema:familyName Onishi
294 schema:givenName Yuko
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75
296 rdf:type schema:Person
297 sg:pub.10.1007/s00380-012-0236-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040113328
298 https://doi.org/10.1007/s00380-012-0236-7
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s00380-013-0382-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007366485
301 https://doi.org/10.1007/s00380-013-0382-6
302 rdf:type schema:CreativeWork
303 grid-institutes:None schema:alternateName Cardiovascular Imaging Center, Toyohashi, Japan
304 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
305 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
306 schema:name Cardiovascular Imaging Center, Toyohashi, Japan
307 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
308 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
309 rdf:type schema:Organization
310 grid-institutes:grid.264706.1 schema:alternateName Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
311 schema:name Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
312 rdf:type schema:Organization
313 grid-institutes:grid.265061.6 schema:alternateName Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
314 schema:name Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
315 rdf:type schema:Organization
316 grid-institutes:grid.410714.7 schema:alternateName Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
317 schema:name Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
318 rdf:type schema:Organization
319 grid-institutes:grid.410818.4 schema:alternateName Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
320 schema:name Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
321 rdf:type schema:Organization
322 grid-institutes:grid.413045.7 schema:alternateName Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
323 schema:name Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
324 rdf:type schema:Organization
325 grid-institutes:grid.414150.5 schema:alternateName Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
326 schema:name Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
327 rdf:type schema:Organization
328 grid-institutes:grid.416698.4 schema:alternateName Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
329 schema:name Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
330 rdf:type schema:Organization
331 grid-institutes:grid.417368.f schema:alternateName Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
332 schema:name Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
333 rdf:type schema:Organization
334 grid-institutes:grid.417369.e schema:alternateName Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
335 schema:name Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
336 rdf:type schema:Organization
337 grid-institutes:grid.419708.3 schema:alternateName Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
338 schema:name Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
339 rdf:type schema:Organization
340 grid-institutes:grid.459497.2 schema:alternateName Department of Cardiology, Ebina General Hospital, Ebina, Japan
341 schema:name Department of Cardiology, Ebina General Hospital, Ebina, Japan
342 rdf:type schema:Organization
343 grid-institutes:grid.461876.a schema:alternateName Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
344 schema:name Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
345 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...