Impacts of age on coronary atherosclerosis and vascular response to statin therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-30

AUTHORS

Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Tsutomu Hirano, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

ABSTRACT

Age is a well-established risk factor for cardiovascular disease. Recent trials using intravascular ultrasound (IVUS) have shown that lipid-lowering therapy with statins halts the progression or induces the regression of coronary artery plaques. However, impacts of age on coronary atherosclerosis and vascular response to statin therapy have not been fully evaluated. The effects of 8-month statin therapy on coronary atherosclerosis were evaluated using virtual histology-IVUS. IVUS data were analyzed from 119 patients who were divided into two groups according to age: elderly patients (≥65 years, n = 72) and non-elderly patients (<65 years, n = 47). No patients were taking statins or other lipid-lowering therapies at baseline. At baseline, external elastic membrane (EEM) volume (17.27 vs. 14.95 mm3/mm, p = 0.02) and plaque volume (9.49 vs. 8.11 mm3/mm, p = 0.03) in the elderly patients were significantly greater than in the non-elderly patients. The EEM volume (−2.4 %, p = 0.007) and plaque volume (−3.1 %, p = 0.007) after 8-month of statin therapy had significantly decreased in the non-elderly patients but not in the elderly patients. A significant positive correlation was observed between age and percentage change in plaque volume (r = 0.265, p = 0.004). A multivariate regression analysis showed that age was a significant predictor of the percentage change in plaque volume during statin therapy (β = 0.223, p = 0.02). Coronary atherosclerosis was more advanced and vascular responses to statin therapy were attenuated in the elderly patients compared to the non-elderly patients. More... »

PAGES

456-463

Journal

TITLE

Heart and Vessels

ISSUE

4

VOLUME

29

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-013-0387-1

DOI

http://dx.doi.org/10.1007/s00380-013-0387-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035029925

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23812594


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0387-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0387-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00380-013-0387-1'


 

This table displays all metadata directly associated to this object as RDF triples.

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27 schema:description Age is a well-established risk factor for cardiovascular disease. Recent trials using intravascular ultrasound (IVUS) have shown that lipid-lowering therapy with statins halts the progression or induces the regression of coronary artery plaques. However, impacts of age on coronary atherosclerosis and vascular response to statin therapy have not been fully evaluated. The effects of 8-month statin therapy on coronary atherosclerosis were evaluated using virtual histology-IVUS. IVUS data were analyzed from 119 patients who were divided into two groups according to age: elderly patients (≥65 years, n = 72) and non-elderly patients (<65 years, n = 47). No patients were taking statins or other lipid-lowering therapies at baseline. At baseline, external elastic membrane (EEM) volume (17.27 vs. 14.95 mm3/mm, p = 0.02) and plaque volume (9.49 vs. 8.11 mm3/mm, p = 0.03) in the elderly patients were significantly greater than in the non-elderly patients. The EEM volume (−2.4 %, p = 0.007) and plaque volume (−3.1 %, p = 0.007) after 8-month of statin therapy had significantly decreased in the non-elderly patients but not in the elderly patients. A significant positive correlation was observed between age and percentage change in plaque volume (r = 0.265, p = 0.004). A multivariate regression analysis showed that age was a significant predictor of the percentage change in plaque volume during statin therapy (β = 0.223, p = 0.02). Coronary atherosclerosis was more advanced and vascular responses to statin therapy were attenuated in the elderly patients compared to the non-elderly patients.
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