Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-01-21

AUTHORS

Kenichi Fukushima, Yoshio Kobayashi, Hideki Kitahara, Yo Iwata, Nakabumi Kuroda, Masayuki Ooyama, Yoichi Kuwabara, Fumio Nomura, Issei Komuro

ABSTRACT

In the United States and Europe, patients with coronary stents are maintained on 75 mg clopidogrel. Because the maintenance dose of ticlopidine in patients with coronary stents is 100 mg twice daily in Japan and 250 mg twice daily in the United States and Europe, in Japanese patients a lower dose of clopidogrel may achieve an antiplatelet effect comparable to 200 mg ticlopidine. Platelet aggregation was evaluated in 104 consecutive patients on 50 mg clopidogrel plus aspirin (n = 54) and 200 mg ticlopidine plus aspirin (n = 50). Platelets were stimulated with adenosine diphosphate (5 and 20 μmol/l) and aggregation was assessed by optical aggregometry. There was no significant difference in platelet aggregation induced with 5 (37% ± 11% vs 38% ± 15%, not significant) and 20 μmol/l adenosine diphosphate (48% ± 13% vs 51% ± 12%, not significant) between 50 mg clopidogrel and 200 mg ticlopidine. In Japanese patients, there is the possibility that a maintenance dose of 50 mg clopidogrel on platelet inhibition is comparable to 200 mg ticlopidine. More... »

PAGES

41-44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-009-1165-y

DOI

http://dx.doi.org/10.1007/s00380-009-1165-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048142301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20091397


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