Adult male northern elephant seals maintain high rates of glucose production during extended breeding fasts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Daniel E. Crocker, Brian K. Wenzel, Cory D. Champagne, Dorian S. Houser

ABSTRACT

Many species undergo natural fasts as part of their life histories. Extended fasting is associated with increased β-oxidation of fatty acids and reduced oxidation of glucose to minimize commitment of body protein to gluconeogenesis. However, the metabolic strategies used to sustain extended fasts simultaneous with high rates of energy expenditure are not well understood. Studies in fasting adult female and weanling northern elephant seals (NES) have revealed high rates of endogenous glucose production (EGP) under constraints of high nutrient demand for lactation or development but relatively low rates of metabolism. These studies revealed low rates of glucose oxidation and high rates of glucose recycling through the Cori cycle. We measured rates of glucose flux in fasting adult male NES to assess how significantly longer fasting durations, higher metabolic rates, and greater rates of muscular activity affect glucose kinetics. We measured glucose turnover in 18 adult males using the clearance of [6-H3] glucose during breeding and molting. Adult male NES maintain high rates of EGP across extended fasts. EGP greatly exceeded estimated needs for glucose-dependent tissues, varied directly with plasma insulin and lactate concentrations, and was inversely related to plasma ketoacid concentrations. Together, these findings suggest that high rates of glucose production and recycling during breeding maintain high blood glucose levels to support glucose-dependent tissues while minimizing production of ketoacids and commitment of protein stores to glucose production. More... »

PAGES

1183-1192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00360-017-1098-1

DOI

http://dx.doi.org/10.1007/s00360-017-1098-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084906511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28421289


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucagon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Seals, Earless", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sonoma State University", 
          "id": "https://www.grid.ac/institutes/grid.263759.c", 
          "name": [
            "Department of Biology, Sonoma State University, 1801 E. Cotati Ave., 94928, Rohnert Park, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crocker", 
        "givenName": "Daniel E.", 
        "id": "sg:person.0763026774.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763026774.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sonoma State University", 
          "id": "https://www.grid.ac/institutes/grid.263759.c", 
          "name": [
            "Department of Biology, Sonoma State University, 1801 E. Cotati Ave., 94928, Rohnert Park, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wenzel", 
        "givenName": "Brian K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Marine Mammal Foundation", 
          "id": "https://www.grid.ac/institutes/grid.419692.1", 
          "name": [
            "National Marine Mammal Foundation, 92106, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Champagne", 
        "givenName": "Cory D.", 
        "id": "sg:person.01314235271.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314235271.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Marine Mammal Foundation", 
          "id": "https://www.grid.ac/institutes/grid.419692.1", 
          "name": [
            "National Marine Mammal Foundation, 92106, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houser", 
        "givenName": "Dorian S.", 
        "id": "sg:person.01232151607.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232151607.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ygcen.2015.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000624468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygcen.2015.09.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000624468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-7692.1991.tb00562.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000778756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00101.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002110123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-29056-5_19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003451032", 
          "https://doi.org/10.1007/978-3-642-29056-5_19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.01476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003526448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00042.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004115935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1890/0012-9658(2001)082[3541:mtarei]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005551843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005914391", 
          "https://doi.org/10.1038/nature07349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00570.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006141762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1890/0012-9615(2000)070[0353:feones]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010372635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9629(97)00020-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010931325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00360-013-0768-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011160020", 
          "https://doi.org/10.1007/s00360-013-0768-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00360-012-0720-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014260974", 
          "https://doi.org/10.1007/s00360-012-0720-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1029/ar018p0109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014705035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00104.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019128387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2006.00582.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019967647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.042135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022726284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/phy2.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022919952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7998.1998.tb00133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024611470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7998.1998.tb00133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024611470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.018176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024977211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6109(02)00193-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026561229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1095-6433(00)00358-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026577154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/zo9870207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027186713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/an.113.004663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027618723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0038442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028743902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1020623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035718955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1020623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035718955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00478.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035737980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.90795.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038466445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039277193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygcen.2013.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039555223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00360-003-0353-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042054967", 
          "https://doi.org/10.1007/s00360-003-0353-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-004-0385-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043440857", 
          "https://doi.org/10.1007/s00429-004-0385-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.068833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043974948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbpa.2010.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044772442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbpa.2011.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047708648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.1991.tb09118.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050671749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci105481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052827950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/284579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058594702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058790357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/528777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058795314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/663634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058848946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/physzool.61.1.30163730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058930810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7209545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062644956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00054.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063195936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/1380997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069461621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.47.7.1101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.2001.280.3.r790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074752891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.6.7.1563593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076989782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077181912", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.1986.250.3.r452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080051736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083296500", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Many species undergo natural fasts as part of their life histories. Extended fasting is associated with increased \u03b2-oxidation of fatty acids and reduced oxidation of glucose to minimize commitment of body protein to gluconeogenesis. However, the metabolic strategies used to sustain extended fasts simultaneous with high rates of energy expenditure are not well understood. Studies in fasting adult female and weanling northern elephant seals (NES) have revealed high rates of endogenous glucose production (EGP) under constraints of high nutrient demand for lactation or development but relatively low rates of metabolism. These studies revealed low rates of glucose oxidation and high rates of glucose recycling through the Cori cycle. We measured rates of glucose flux in fasting adult male NES to assess how significantly longer fasting durations, higher metabolic rates, and greater rates of muscular activity affect glucose kinetics. We measured glucose turnover in 18 adult males using the clearance of [6-H3] glucose during breeding and molting. Adult male NES maintain high rates of EGP across extended fasts. EGP greatly exceeded estimated needs for glucose-dependent tissues, varied directly with plasma insulin and lactate concentrations, and was inversely related to plasma ketoacid concentrations. Together, these findings suggest that high rates of glucose production and recycling during breeding maintain high blood glucose levels to support glucose-dependent tissues while minimizing production of ketoacids and commitment of protein stores to glucose production.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00360-017-1098-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3090347", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1312193", 
        "issn": [
          "0174-1578", 
          "1432-136X"
        ], 
        "name": "Journal of Comparative Physiology B", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "187"
      }
    ], 
    "name": "Adult male northern elephant seals maintain high rates of glucose production during extended breeding fasts", 
    "pagination": "1183-1192", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7300a3afd1db9d651959ce0417bae62d3bda7310194709a7f3023f17794f6a06"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28421289"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8413200"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00360-017-1098-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084906511"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00360-017-1098-1", 
      "https://app.dimensions.ai/details/publication/pub.1084906511"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99829_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00360-017-1098-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00360-017-1098-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00360-017-1098-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00360-017-1098-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00360-017-1098-1'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      91 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00360-017-1098-1 schema:about N268725f22aa44b21ba14db64fa8220d5
2 N39f8d87009be4e7da6059c5769f67617
3 N534ad710cd224dea8713d818c3f52e45
4 N5b2d911dbd824e11a4cf00a78b4dfe5f
5 N673dedb36c4a46a8945b08428285ba5d
6 N6efbe102ed5d459b9272a63f3b43e15c
7 N896e3fd062dd4dbd93673ef1e454460b
8 N94546e4debaf4750a8a20c3d13a23f83
9 N9b9cf1e2f33d465bafd085414ca9833c
10 Nc1aacc6be608435c8852184eb28da7bb
11 Nfaa87c390272466f98e1fc41fcd71d52
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author N59267c114d38430daa20108f650b7639
15 schema:citation sg:pub.10.1007/978-3-642-29056-5_19
16 sg:pub.10.1007/s00360-003-0353-9
17 sg:pub.10.1007/s00360-012-0720-5
18 sg:pub.10.1007/s00360-013-0768-x
19 sg:pub.10.1007/s00429-004-0385-2
20 sg:pub.10.1038/nature07349
21 https://app.dimensions.ai/details/publication/pub.1077181912
22 https://app.dimensions.ai/details/publication/pub.1083296500
23 https://doi.org/10.1002/phy2.23
24 https://doi.org/10.1016/j.cbpa.2010.01.002
25 https://doi.org/10.1016/j.cbpa.2011.12.013
26 https://doi.org/10.1016/j.ygcen.2013.11.005
27 https://doi.org/10.1016/j.ygcen.2015.09.024
28 https://doi.org/10.1016/s0039-6109(02)00193-7
29 https://doi.org/10.1016/s0300-9629(97)00020-0
30 https://doi.org/10.1016/s1095-6433(00)00358-5
31 https://doi.org/10.1029/ar018p0109
32 https://doi.org/10.1042/bj1020623
33 https://doi.org/10.1071/zo9870207
34 https://doi.org/10.1086/284579
35 https://doi.org/10.1086/515971
36 https://doi.org/10.1086/528777
37 https://doi.org/10.1086/663634
38 https://doi.org/10.1086/physzool.61.1.30163730
39 https://doi.org/10.1096/fasebj.6.7.1563593
40 https://doi.org/10.1111/j.1469-7580.2006.00582.x
41 https://doi.org/10.1111/j.1469-7998.1998.tb00133.x
42 https://doi.org/10.1111/j.1748-1716.1991.tb09118.x
43 https://doi.org/10.1111/j.1748-7692.1991.tb00562.x
44 https://doi.org/10.1126/science.7209545
45 https://doi.org/10.1152/ajpendo.00104.2006
46 https://doi.org/10.1152/ajpregu.00042.2012
47 https://doi.org/10.1152/ajpregu.00054.2015
48 https://doi.org/10.1152/ajpregu.00101.2012
49 https://doi.org/10.1152/ajpregu.00478.2010
50 https://doi.org/10.1152/ajpregu.00570.2005
51 https://doi.org/10.1152/ajpregu.1986.250.3.r452
52 https://doi.org/10.1152/ajpregu.2001.280.3.r790
53 https://doi.org/10.1152/ajpregu.90795.2008
54 https://doi.org/10.1172/jci105481
55 https://doi.org/10.1172/jci116951
56 https://doi.org/10.1242/jeb.01476
57 https://doi.org/10.1242/jeb.018176
58 https://doi.org/10.1242/jeb.042135
59 https://doi.org/10.1242/jeb.068833
60 https://doi.org/10.1371/journal.pone.0038442
61 https://doi.org/10.1890/0012-9615(2000)070[0353:feones]2.0.co;2
62 https://doi.org/10.1890/0012-9658(2001)082[3541:mtarei]2.0.co;2
63 https://doi.org/10.2307/1380997
64 https://doi.org/10.2337/diabetes.47.7.1101
65 https://doi.org/10.3945/an.113.004663
66 schema:datePublished 2017-12
67 schema:datePublishedReg 2017-12-01
68 schema:description Many species undergo natural fasts as part of their life histories. Extended fasting is associated with increased β-oxidation of fatty acids and reduced oxidation of glucose to minimize commitment of body protein to gluconeogenesis. However, the metabolic strategies used to sustain extended fasts simultaneous with high rates of energy expenditure are not well understood. Studies in fasting adult female and weanling northern elephant seals (NES) have revealed high rates of endogenous glucose production (EGP) under constraints of high nutrient demand for lactation or development but relatively low rates of metabolism. These studies revealed low rates of glucose oxidation and high rates of glucose recycling through the Cori cycle. We measured rates of glucose flux in fasting adult male NES to assess how significantly longer fasting durations, higher metabolic rates, and greater rates of muscular activity affect glucose kinetics. We measured glucose turnover in 18 adult males using the clearance of [6-H<sup>3</sup>] glucose during breeding and molting. Adult male NES maintain high rates of EGP across extended fasts. EGP greatly exceeded estimated needs for glucose-dependent tissues, varied directly with plasma insulin and lactate concentrations, and was inversely related to plasma ketoacid concentrations. Together, these findings suggest that high rates of glucose production and recycling during breeding maintain high blood glucose levels to support glucose-dependent tissues while minimizing production of ketoacids and commitment of protein stores to glucose production.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N295ab9b2ded14a98bdd904f60b7e81f0
73 N7ed4ccb4533f42ff81f77cfb1a3ed971
74 sg:journal.1312193
75 schema:name Adult male northern elephant seals maintain high rates of glucose production during extended breeding fasts
76 schema:pagination 1183-1192
77 schema:productId N435c95c4fcce4210bc7169bf881a24fa
78 N6fdac3f0e76b487fb1e08e73992b8af3
79 N7805911d902b405185fa7affe1aa04ca
80 N8fe44ed7f29f42aea3b1e9d9944c4bc4
81 N9145d63cd9a046d8b5a2f636abc97623
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084906511
83 https://doi.org/10.1007/s00360-017-1098-1
84 schema:sdDatePublished 2019-04-11T09:37
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N2f88a8beec974877900717ba75b1ee22
87 schema:url https://link.springer.com/10.1007%2Fs00360-017-1098-1
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N0d54462daf9849d5aea30cf1a7cbfecb rdf:first sg:person.01314235271.51
92 rdf:rest Na6527ce8235e402a8e842df6243e231f
93 N268725f22aa44b21ba14db64fa8220d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Animals
95 rdf:type schema:DefinedTerm
96 N295ab9b2ded14a98bdd904f60b7e81f0 schema:issueNumber 8
97 rdf:type schema:PublicationIssue
98 N2f88a8beec974877900717ba75b1ee22 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N39f8d87009be4e7da6059c5769f67617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Blood Glucose
102 rdf:type schema:DefinedTerm
103 N435c95c4fcce4210bc7169bf881a24fa schema:name doi
104 schema:value 10.1007/s00360-017-1098-1
105 rdf:type schema:PropertyValue
106 N534ad710cd224dea8713d818c3f52e45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Glucose
108 rdf:type schema:DefinedTerm
109 N59267c114d38430daa20108f650b7639 rdf:first sg:person.0763026774.45
110 rdf:rest N938fa5ff7ba6454ab5883a1b2c0234ad
111 N5b2d911dbd824e11a4cf00a78b4dfe5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Fasting
113 rdf:type schema:DefinedTerm
114 N673dedb36c4a46a8945b08428285ba5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Seals, Earless
116 rdf:type schema:DefinedTerm
117 N6efbe102ed5d459b9272a63f3b43e15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Molting
119 rdf:type schema:DefinedTerm
120 N6fdac3f0e76b487fb1e08e73992b8af3 schema:name dimensions_id
121 schema:value pub.1084906511
122 rdf:type schema:PropertyValue
123 N7805911d902b405185fa7affe1aa04ca schema:name nlm_unique_id
124 schema:value 8413200
125 rdf:type schema:PropertyValue
126 N7ed4ccb4533f42ff81f77cfb1a3ed971 schema:volumeNumber 187
127 rdf:type schema:PublicationVolume
128 N896e3fd062dd4dbd93673ef1e454460b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Insulin
130 rdf:type schema:DefinedTerm
131 N8fe44ed7f29f42aea3b1e9d9944c4bc4 schema:name pubmed_id
132 schema:value 28421289
133 rdf:type schema:PropertyValue
134 N9145d63cd9a046d8b5a2f636abc97623 schema:name readcube_id
135 schema:value 7300a3afd1db9d651959ce0417bae62d3bda7310194709a7f3023f17794f6a06
136 rdf:type schema:PropertyValue
137 N938fa5ff7ba6454ab5883a1b2c0234ad rdf:first Nde4e6f4d464b496a99ffd93eafff0f88
138 rdf:rest N0d54462daf9849d5aea30cf1a7cbfecb
139 N94546e4debaf4750a8a20c3d13a23f83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Lactic Acid
141 rdf:type schema:DefinedTerm
142 N9b9cf1e2f33d465bafd085414ca9833c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Glucagon
144 rdf:type schema:DefinedTerm
145 Na6527ce8235e402a8e842df6243e231f rdf:first sg:person.01232151607.51
146 rdf:rest rdf:nil
147 Nc1aacc6be608435c8852184eb28da7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Reproduction
149 rdf:type schema:DefinedTerm
150 Nde4e6f4d464b496a99ffd93eafff0f88 schema:affiliation https://www.grid.ac/institutes/grid.263759.c
151 schema:familyName Wenzel
152 schema:givenName Brian K.
153 rdf:type schema:Person
154 Nfaa87c390272466f98e1fc41fcd71d52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Male
156 rdf:type schema:DefinedTerm
157 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
158 schema:name Biological Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biochemistry and Cell Biology
162 rdf:type schema:DefinedTerm
163 sg:grant.3090347 http://pending.schema.org/fundedItem sg:pub.10.1007/s00360-017-1098-1
164 rdf:type schema:MonetaryGrant
165 sg:journal.1312193 schema:issn 0174-1578
166 1432-136X
167 schema:name Journal of Comparative Physiology B
168 rdf:type schema:Periodical
169 sg:person.01232151607.51 schema:affiliation https://www.grid.ac/institutes/grid.419692.1
170 schema:familyName Houser
171 schema:givenName Dorian S.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232151607.51
173 rdf:type schema:Person
174 sg:person.01314235271.51 schema:affiliation https://www.grid.ac/institutes/grid.419692.1
175 schema:familyName Champagne
176 schema:givenName Cory D.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314235271.51
178 rdf:type schema:Person
179 sg:person.0763026774.45 schema:affiliation https://www.grid.ac/institutes/grid.263759.c
180 schema:familyName Crocker
181 schema:givenName Daniel E.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763026774.45
183 rdf:type schema:Person
184 sg:pub.10.1007/978-3-642-29056-5_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003451032
185 https://doi.org/10.1007/978-3-642-29056-5_19
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/s00360-003-0353-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042054967
188 https://doi.org/10.1007/s00360-003-0353-9
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s00360-012-0720-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014260974
191 https://doi.org/10.1007/s00360-012-0720-5
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00360-013-0768-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011160020
194 https://doi.org/10.1007/s00360-013-0768-x
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s00429-004-0385-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043440857
197 https://doi.org/10.1007/s00429-004-0385-2
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nature07349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005914391
200 https://doi.org/10.1038/nature07349
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1077181912 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1083296500 schema:CreativeWork
204 https://doi.org/10.1002/phy2.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022919952
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.cbpa.2010.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044772442
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.cbpa.2011.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047708648
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ygcen.2013.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039555223
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.ygcen.2015.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000624468
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0039-6109(02)00193-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026561229
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0300-9629(97)00020-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010931325
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s1095-6433(00)00358-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026577154
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1029/ar018p0109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014705035
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1042/bj1020623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035718955
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1071/zo9870207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027186713
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1086/284579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058594702
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1086/515971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058790357
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1086/528777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058795314
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1086/663634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058848946
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1086/physzool.61.1.30163730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058930810
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1096/fasebj.6.7.1563593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076989782
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1469-7580.2006.00582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019967647
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/j.1469-7998.1998.tb00133.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024611470
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1748-1716.1991.tb09118.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050671749
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1748-7692.1991.tb00562.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000778756
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.7209545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062644956
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1152/ajpendo.00104.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019128387
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1152/ajpregu.00042.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004115935
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1152/ajpregu.00054.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063195936
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1152/ajpregu.00101.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002110123
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1152/ajpregu.00478.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035737980
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1152/ajpregu.00570.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006141762
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1152/ajpregu.1986.250.3.r452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080051736
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1152/ajpregu.2001.280.3.r790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074752891
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/ajpregu.90795.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038466445
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1172/jci105481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052827950
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci116951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039277193
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1242/jeb.01476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003526448
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1242/jeb.018176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024977211
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1242/jeb.042135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022726284
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1242/jeb.068833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043974948
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1371/journal.pone.0038442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028743902
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1890/0012-9615(2000)070[0353:feones]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010372635
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1890/0012-9658(2001)082[3541:mtarei]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005551843
283 rdf:type schema:CreativeWork
284 https://doi.org/10.2307/1380997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069461621
285 rdf:type schema:CreativeWork
286 https://doi.org/10.2337/diabetes.47.7.1101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743899
287 rdf:type schema:CreativeWork
288 https://doi.org/10.3945/an.113.004663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027618723
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.263759.c schema:alternateName Sonoma State University
291 schema:name Department of Biology, Sonoma State University, 1801 E. Cotati Ave., 94928, Rohnert Park, CA, USA
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.419692.1 schema:alternateName National Marine Mammal Foundation
294 schema:name National Marine Mammal Foundation, 92106, San Diego, CA, USA
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...