Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Gregory L. Florant, Heather Porst, Aubrey Peiffer, Susan F. Hudachek, Chris Pittman, Scott A.Summers, Michael W. Rajala, Philipp E. Scherer

ABSTRACT

Leptin and adiponectin are proteins produced and secreted from white adipose tissue and are important regulators of energy balance and insulin sensitivity. Seasonal changes in leptin and adiponectin have not been investigated in mammalian hibernators in relationship to changes in fat cell and fat mass. We sought to determine the relationship between serum leptin and adiponectin levels with seasonal changes in lipid mass. We collected serum and tissue samples from marmots (Marmota flaviventris) in different seasons while measuring changes in fat mass, including fat-cell size. We found that leptin is positively associated with increasing fat mass and fat-cell size, while adiponectin is negatively associated with increasing lipid mass. These findings are consistent with the putative roles of these adipokines: leptin increases with fat mass and is involved in enhancing lipid oxidation while adiponectin appears to be higher in summer when hepatic insulin sensitivity should be maintained since the animals are eating. Our data suggest that during autumn/winter animals have switched from a lipogenic condition to a lipolytic state, which may include leptin resistance. More... »

PAGES

633-639

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00360-004-0454-0

DOI

http://dx.doi.org/10.1007/s00360-004-0454-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000537209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15517283


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