Tamoxifen-Retinopathie: Eine Fallserie von klinischen und funktionelle Daten View Full Text


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Article Info

DATE

2008-06

AUTHORS

C. Ritter, A.B. Renner, J. Wachtlin, N.E. Bechrakis, L. Krause

ABSTRACT

BACKGROUND: Tamoxifen is used in the treatment of selected patients with breast carcinoma. Rarely, it has been shown to cause ocular toxic effects including crystalline retinopathy. METHODS: Retrospective analysis of clinical and functional (visual acuity, visual field, colour vision) data of a case series of eight female patients under tamoxifen therapy with electrophysiological examination. RESULTS: Seven of eight patients complained of visual disturbances. In one case, examination showed crystalline deposits in the cornea and macular area. Three patients revealed changes in full-field and multifocal electroretinogram, and two had a pathological multifocal electroretinogram only. In six cases we applied a desaturated panel D-15 colour vision test; five of these showed some disorders. CONCLUSIONS: Most tamoxifen patients who complained of visual disturbances showed electrophysiological changes, particularly in the multifocal electroretinogram and often without a certain morphological correlate. We recommend electrophysiological examination for patients with unclear visual deterioration who are receiving tamoxifen therapy. More... »

PAGES

544

References to SciGraph publications

  • 2001-01. Elektrophysiologische Untersuchungen bei Mammakarzinompatientinnen mit Tamoxifen-Retinopathie in DER OPHTHALMOLOGE
  • 2000-01. Multifocal ERG in chloroquine retinopathy: regional variance of retinal dysfunction in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2004-03. Standard for clinical electroretinography (2004 update) in DOCUMENTA OPHTHALMOLOGICA
  • 2006-09. Optical coherence tomography in tamoxifen retinopathy in BREAST CANCER RESEARCH AND TREATMENT
  • 1998-08. Tamoxifen retinopathy: does it really exist? in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2005-06. Tamoxifen therapy conveys increased risk of developing a macular hole in INTERNATIONAL OPHTHALMOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00347-007-1677-8

    DOI

    http://dx.doi.org/10.1007/s00347-007-1677-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040862915

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18415107


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    56 schema:description BACKGROUND: Tamoxifen is used in the treatment of selected patients with breast carcinoma. Rarely, it has been shown to cause ocular toxic effects including crystalline retinopathy. METHODS: Retrospective analysis of clinical and functional (visual acuity, visual field, colour vision) data of a case series of eight female patients under tamoxifen therapy with electrophysiological examination. RESULTS: Seven of eight patients complained of visual disturbances. In one case, examination showed crystalline deposits in the cornea and macular area. Three patients revealed changes in full-field and multifocal electroretinogram, and two had a pathological multifocal electroretinogram only. In six cases we applied a desaturated panel D-15 colour vision test; five of these showed some disorders. CONCLUSIONS: Most tamoxifen patients who complained of visual disturbances showed electrophysiological changes, particularly in the multifocal electroretinogram and often without a certain morphological correlate. We recommend electrophysiological examination for patients with unclear visual deterioration who are receiving tamoxifen therapy.
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