Efficacy and safety of intradetrusor botulinum toxin injections for idiopathic overactive bladder syndrome in patients with an artificial urinary sphincter View Full Text


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Article Info

DATE

2021-10-09

AUTHORS

Geoffroy de Sallmard, Marie-Aimée Perrouin-Verbe, Benoit Peyronnet, Xavier Biardeau, Delphine Maucort-Boulch, Emmanuel Chartier-Kastler, Véronique Phé, Alexia Even, Charles Joussain, Inès Dominique, Gérard Amarenco, Xavier Gamé, Christian Saussine, Alain Ruffion

ABSTRACT

PurposeTo assess the efficacy and safety of intradetrusor botulinum toxin type A injections (IBTI) for idiopathic overactive bladder (iOAB) in non-neurological adults with an artificial urinary sphincter (AUS).Materials and methodsWe retrospectively selected, in the 11 French centers, members of a collaborative network (GENULF (Groupe d’étude de neuro-urologie de langue francaise)), the patients who had had an artificial urinary sphincter implantation and who had subsequently developed iOAB requiring IBTI. This study was approved by the French association of urology ethics committee (no 2018012).ResultsBetween 2006 and 2020, 33 patients were included from 5 French centers. Mean follow-up after the first IBTI was 47 months. The average age of the studied population was 68 years, with 70% of females. A complete resolution of symptoms at optimal IBTI dose was experienced by 21 (64%) patients. Seven (21%) patients had partial improvement. Five non-responder patients (15%) had no improvement at all. Maximum cystometric bladder capacity was 240 ml pre-IBTI and 335 ml post IBTI. Discontinuation free survival at 60 months was 50%. Two erosions occurred during the 6 months following an IBTI both in male patients with a perineal implantation. There were four AUS balloon perforations that occurred during the 6 months following an IBTI, all of them in female patients.ConclusionsIBTI has a good efficacy for the treatment of iOAB in patients with an AUS. However, both patients and practicians must be aware of the risk of rare and usually mild complications. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-021-03850-y

DOI

http://dx.doi.org/10.1007/s00345-021-03850-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141748890

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34626226


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