Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-26

AUTHORS

J. Curtis Nickel, Alisa Stephens, J. Richard Landis, Chris Mullins, Adrie van Bokhoven, Jennifer T. Anger, A. Lenore Ackerman, Jayoung Kim, Siobhan Sutcliffe, Jaroslaw E. Krol, Bhaswati Sen, Jocelyn Hammond, Garth D. Ehrlich

ABSTRACT

PurposeTo correlate the presence of fungi with symptom flares, pain and urinary severity in a prospective, longitudinal study of women with IC/BPS enrolled in the MAPP Research Network.MethodsFlare status, pelvic pain, urinary severity, and midstream urine were collected at baseline, 6 and 12 months from female IC/BPS participants with at least one flare and age-matched participants with no reported flares. Multilocus PCR coupled with electrospray ionization/mass spectrometry was used for identification of fungal species and genus. Associations between “mycobiome” (species/genus presence, relative abundance, Shannon’s/Chao1 diversity indices) and current flare status, pain, urinary severity were evaluated using generalized linear mixed models, permutational multivariate analysis of variance, Wilcoxon’s rank-sum test.ResultsThe most specific analysis detected 13 fungal species from 8 genera in 504 urine samples from 202 females. A more sensitive analysis detected 43 genera. No overall differences were observed in fungal species/genus composition or diversity by flare status or pain severity. Longitudinal analyses suggested greater fungal diversity (Chao1 Mean Ratio 3.8, 95% CI 1.3–11.2, p = 0.02) and a significantly greater likelihood of detecting any fungal species (OR = 5.26, 95% CI 1.1–25.8, p = 0.04) in high vs low urinary severity participants. Individual taxa analysis showed a trend toward increased presence and relative abundance of Candida (OR = 6.63, 95% CI 0.8–58.5, p = 0.088) and Malassezia (only identified in ‘high’ urinary severity phenotype) for high vs low urinary symptoms.ConclusionThis analysis suggests the possibility that greater urinary symptom severity is associated with the urinary mycobiome urine in some females with IC/BPS. More... »

PAGES

433-446

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-019-02764-0

DOI

http://dx.doi.org/10.1007/s00345-019-02764-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113753797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31028455


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25 schema:description PurposeTo correlate the presence of fungi with symptom flares, pain and urinary severity in a prospective, longitudinal study of women with IC/BPS enrolled in the MAPP Research Network.MethodsFlare status, pelvic pain, urinary severity, and midstream urine were collected at baseline, 6 and 12 months from female IC/BPS participants with at least one flare and age-matched participants with no reported flares. Multilocus PCR coupled with electrospray ionization/mass spectrometry was used for identification of fungal species and genus. Associations between “mycobiome” (species/genus presence, relative abundance, Shannon’s/Chao1 diversity indices) and current flare status, pain, urinary severity were evaluated using generalized linear mixed models, permutational multivariate analysis of variance, Wilcoxon’s rank-sum test.ResultsThe most specific analysis detected 13 fungal species from 8 genera in 504 urine samples from 202 females. A more sensitive analysis detected 43 genera. No overall differences were observed in fungal species/genus composition or diversity by flare status or pain severity. Longitudinal analyses suggested greater fungal diversity (Chao1 Mean Ratio 3.8, 95% CI 1.3–11.2, p = 0.02) and a significantly greater likelihood of detecting any fungal species (OR = 5.26, 95% CI 1.1–25.8, p = 0.04) in high vs low urinary severity participants. Individual taxa analysis showed a trend toward increased presence and relative abundance of Candida (OR = 6.63, 95% CI 0.8–58.5, p = 0.088) and Malassezia (only identified in ‘high’ urinary severity phenotype) for high vs low urinary symptoms.ConclusionThis analysis suggests the possibility that greater urinary symptom severity is associated with the urinary mycobiome urine in some females with IC/BPS.
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31 schema:keywords BPS
32 Candida
33 ConclusionThis analysis
34 IC/BPS
35 MAPP Research Network
36 Malassezia
37 PCR
38 PurposeTo
39 Research Network
40 Taxa Analysis
41 Wilcoxon rank sum test
42 abundance
43 age-matched participants
44 analysis
45 association
46 baseline
47 bladder pain syndrome
48 composition
49 cystitis
50 differences
51 diversity
52 electrospray ionization/mass spectrometry
53 females
54 flare status
55 flares
56 fungal diversity
57 fungal species
58 fungi
59 genus
60 genus composition
61 greater fungal diversity
62 greater likelihood
63 identification
64 interstitial cystitis
65 ionization/mass spectrometry
66 likelihood
67 linear mixed models
68 longitudinal analysis
69 longitudinal study
70 lower urinary symptoms
71 mass spectrometry
72 midstream urine
73 mixed models
74 model
75 months
76 multilocus PCR
77 multivariate analysis
78 network
79 overall difference
80 pain
81 pain severity
82 pain syndrome
83 participants
84 pelvic pain
85 permutational multivariate analysis
86 possibility
87 presence
88 presence of fungi
89 rank sum test
90 relative abundance
91 samples
92 sensitive analysis
93 severity
94 species
95 specific analysis
96 spectrometry
97 status
98 study
99 symptom flares
100 symptom severity
101 symptoms
102 syndrome
103 test
104 trends
105 urinary severity
106 urinary symptom severity
107 urinary symptoms
108 urine
109 urine samples
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111 women
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