Malignant invasion of the central nervous system: the hidden face of a poorly understood outcome of prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Eliane Gouvêa de Oliveira Barros, Nathalia Meireles Da Costa, Celia Yelimar Palmero, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti, Antonio Palumbo Jr.

ABSTRACT

Malignancies of the central nervous system include primary brain tumors and brain metastases, the latter being the major cause of intracranial neoplasms in adults. Although prostate cancer (PCa) brain metastases are not the most common source, recent data show that the relevance of prostate cancer brain metastases (PCBM) cannot be neglected. In this review, we focus on the molecular repertory as well as on the phenotypical similarities between PCBM and primary PCa, such as the cellular evolution and the maintenance of androgen-receptor expression. Moreover, the simultaneous occurrence of PCBM with other PCa metastatic sites and the significance of the clinical heterogeneity of the disease are also discussed. In addition, a potential relationship between the heterogeneous behavior exhibited by PCBM and the co-occurrence of malignant cell clusters with distinct genetic profiles is also hypothesized, as well as the prominent role of astrocytes in the establishment of PCBM. More... »

PAGES

2009-2019

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00345-018-2392-6

    DOI

    http://dx.doi.org/10.1007/s00345-018-2392-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29980839


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