Increased nucleophosmin expression is a strong predictor of recurrence and prognosis in patients with N0M0 upper tract urothelial carcinoma undergoing ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-24

AUTHORS

Harutake Sawazaki, Keiichi Ito, Takako Asano, Kenji Kuroda, Akinori Sato, Junichi Asakuma, Akio Horiguchi, Kenji Seguchi, Tomohiko Asano

ABSTRACT

PurposeWe aimed to evaluate whether increased nucleophosmin expression predicts recurrence and survival in upper tract urothelial carcinoma (UTUC).MethodsSpecimens from 101 patients with N0M0 UTUC undergoing radical nephroureterectomy were evaluated. Nucleophosmin expression was determined immunohistochemically and categorized into two groups according to nucleophosmin staining intensity. The association between nucleophosmin expression and various clinicopathological factors including Ki-67 expression was analyzed. Multivariate analyses were performed to identify the independent predictors of extraurothelial recurrence and cancer-specific survival.ResultsHigh nucleophosmin expression was significantly correlated with tumor location, pT ≥3, lymphovascular invasion, lymph node metastasis, and high Ki-67 expression. Patients whose tumors demonstrated high nucleophosmin expression had a significantly higher rate of extraurothelial recurrence and a lower survival rate than those with low nucleophosmin expression. Multivariate analysis showed that pT ≥3, lymph node metastasis, high nucleophosmin expression, and high Ki-67 expression were independent predictors of extraurothelial recurrence. When patients were stratified into three groups according to the number of risk factors, the 2-year extraurothelial recurrence-free survival rates were 92.9% in patients with 0 or 1 risk factor, 76.5% in patients with 2 risk factors, and 9.1% in patients with 3 or 4 risk factors. Regarding cancer-specific survival, lymphovascular invasion and high nucleophosmin expression were independent predictors.ConclusionsIncreased nucleophosmin expression was a strong predictor of extraurothelial recurrence and cancer-specific survival in patients with N0M0 UTUC undergoing radical nephroureterectomy. Our risk stratification models integrating nucleophosmin expression may provide valuable information on disease recurrence and prognosis. More... »

PAGES

1081-1088

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-016-1977-1

DOI

http://dx.doi.org/10.1007/s00345-016-1977-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018767141

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27885451


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