Prognostic role of expression of N-cadherin in patients with upper tract urothelial carcinoma: a multi-institutional study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-09

AUTHORS

Mohammad Abufaraj, Marco Moschini, Francesco Soria, Kilian Gust, Mehmet Özsoy, Romain Mathieu, Morgan Rouprêt, Vitaly Margulis, Jose A. Karam, Christopher G. Wood, Alberto Briganti, Karim Bensalah, Andrea Haitel, Shahrokh F. Shariat

ABSTRACT

PurposeTo assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients.Patients and methodsImmunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The Kaplan–Meier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival. Disease recurrence, overall mortality and cancer-specific mortality probabilities were tested in Cox regression models.ResultsExpression of N-cadherin was observed in 292 (43.1%) of patients, and it was associated with advanced tumour stage (p < 0.04), lymph node metastases (p = 0.04) and sessile architecture (p < 0.02). Within a median follow-up of 37.5 months (IQR 20–66), 171 patients (25.2%) experienced disease recurrence and 150 (22.1%) died from UTUC. In univariable analyses, N-cadherin expression was significantly associated with higher probability of recurrence (p = 0.01), but not overall (p = 0.9) or cancer-specific mortality (p = 0.06). When adjusted for the effects of all available confounders, N-cadherin was not associated with any of the survival outcomes.ConclusionN-cadherin is expressed in approximately 2/5 of UTUs. It is associated with adverse pathologic factors but not with survival outcomes. Its clinical value remains limited. More... »

PAGES

1073-1080

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-016-1968-2

DOI

http://dx.doi.org/10.1007/s00345-016-1968-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033230294

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27830374


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26 schema:description PurposeTo assess the role of N-cadherin as prognostic biomarker in patients with upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients.Patients and methodsImmunohistochemistry was used to evaluate the status of N-cadherin expression in 678 patients with unilateral sporadic UTUC treated with radical nephroureterectomy. N-cadherin was considered positive if any immunoreactivity with membranous staining was detected. The Kaplan–Meier method was used to estimate recurrence-free survival, overall survival and cancer-specific survival. Disease recurrence, overall mortality and cancer-specific mortality probabilities were tested in Cox regression models.ResultsExpression of N-cadherin was observed in 292 (43.1%) of patients, and it was associated with advanced tumour stage (p < 0.04), lymph node metastases (p = 0.04) and sessile architecture (p < 0.02). Within a median follow-up of 37.5 months (IQR 20–66), 171 patients (25.2%) experienced disease recurrence and 150 (22.1%) died from UTUC. In univariable analyses, N-cadherin expression was significantly associated with higher probability of recurrence (p = 0.01), but not overall (p = 0.9) or cancer-specific mortality (p = 0.06). When adjusted for the effects of all available confounders, N-cadherin was not associated with any of the survival outcomes.ConclusionN-cadherin is expressed in approximately 2/5 of UTUs. It is associated with adverse pathologic factors but not with survival outcomes. Its clinical value remains limited.
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32 schema:keywords Cox regression model
33 Kaplan-Meier method
34 MethodsImmunohistochemistry
35 N-cadherin
36 N-cadherin expression
37 PurposeTo
38 ResultsExpression
39 UTU
40 advanced tumor stage
41 adverse pathologic factors
42 analysis
43 architecture
44 available confounders
45 biomarkers
46 cancer-specific mortality
47 cancer-specific survival
48 carcinoma
49 clinical value
50 cohort
51 confounders
52 disease recurrence
53 effect
54 expression
55 factors
56 high probability
57 immunoreactivity
58 large multi-institutional cohort
59 lymph node metastasis
60 membranous staining
61 metastasis
62 method
63 model
64 months
65 mortality
66 mortality probability
67 multi-institutional cohort
68 multi-institutional study
69 nephroureterectomy
70 node metastasis
71 outcomes
72 overall mortality
73 overall survival
74 pathologic factors
75 patients
76 probability
77 prognostic biomarker
78 prognostic role
79 radical nephroureterectomy
80 recurrence
81 recurrence-free survival
82 regression models
83 role
84 sessile architecture
85 sporadic upper tract urothelial carcinoma
86 stage
87 staining
88 status
89 study
90 survival
91 survival outcomes
92 tumor stage
93 univariable analysis
94 upper tract urothelial carcinoma
95 urothelial carcinoma
96 values
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