HER2 overexpression is associated with worse outcomes in patients with upper tract urothelial carcinoma (UTUC) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06-07

AUTHORS

Francesco Soria, Marco Moschini, Andrea Haitel, Gregory J. Wirth, Jose A. Karam, Christopher G. Wood, Morgan Rouprêt, Vitaly Margulis, Pierre I. Karakiewicz, Alberto Briganti, Jay D. Raman, Solene-Florence Kammerer-Jacquet, Romain Mathieu, Karim Bensalah, Yair Lotan, Mehmet Özsoy, Mesut Remzi, Kilian M. Gust, Shahrokh F. Shariat

ABSTRACT

PurposeThe aim of our study was to evaluate the expression pattern of HER2 overexpression in patients with upper tract urothelial carcinoma (UTUC) and to evaluate its association with clinical outcomes.MethodsThis multicenter retrospective study included 732 patients treated with radical nephroureterectomy for UTUC. HER2 expression was assessed using immunohistochemistry and scored according to the HercepTest: Scores of 0 or 1 were considered negative and 2 or 3 as positive. To qualify for 2 scoring, complete membrane staining of more than 10 % of tumor cells at a moderate intensity had to be observed.ResultsHER2 was overexpressed in 262 (35.8 %) patients. It was associated with pathologic characteristics such as more advanced T stage (p < 0.001), presence of lymph node metastasis (p = 0.006), high-grade tumor (p < 0.001), tumor necrosis (p = 0.01) and lymphovascular invasion (p = 0.02). Patients with HER2 overexpression had a 1.66-fold increased risk of experiencing disease recurrence (95 % CI 1.24–2.24, p = 0.001), 1.55-fold increased risk of death (95 % CI 1.21–1.99, p = 0.001) and 1.81-fold increased risk of cancer-specific death (95 % CI 1.33–2.48, p < 0.001). On multivariable analysis that adjusted for the effects of standard clinicopathologic variables, HER2 overexpression remained associated with disease recurrence (p = 0.04), overall (p = 0.02) and cancer-specific mortality (p = 0.02).ConclusionsApproximately, one-third of UTUC patients overexpressed HER2. HER2 overexpression was associated with features of clinically and biologically aggressive disease as well as prognosis. HER2 may represent a good marker for therapeutic risk stratification and potentially a target for therapy in some UTUC tumors. More... »

PAGES

251-259

Journal

TITLE

World Journal of Urology

ISSUE

2

VOLUME

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-016-1871-x

DOI

http://dx.doi.org/10.1007/s00345-016-1871-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010903159

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27272502


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    "description": "PurposeThe aim of our study was to evaluate the expression pattern of HER2 overexpression in patients with upper tract urothelial carcinoma (UTUC) and to evaluate its association with clinical outcomes.MethodsThis multicenter retrospective study included 732 patients treated with radical nephroureterectomy for UTUC. HER2 expression was assessed using immunohistochemistry and scored according to the HercepTest: Scores of 0 or 1 were considered negative and 2 or 3 as positive. To qualify for 2 scoring, complete membrane staining of more than 10\u00a0% of tumor cells at a moderate intensity had to be observed.ResultsHER2 was overexpressed in 262 (35.8\u00a0%) patients. It was associated with pathologic characteristics such as more advanced T stage (p\u00a0<\u00a00.001), presence of lymph node metastasis (p\u00a0=\u00a00.006), high-grade tumor (p\u00a0<\u00a00.001), tumor necrosis (p\u00a0=\u00a00.01) and lymphovascular invasion (p\u00a0=\u00a00.02). Patients with HER2 overexpression had a 1.66-fold increased risk of experiencing disease recurrence (95\u00a0% CI 1.24\u20132.24, p\u00a0=\u00a00.001), 1.55-fold increased risk of death (95\u00a0% CI 1.21\u20131.99, p\u00a0=\u00a00.001) and 1.81-fold increased risk of cancer-specific death (95\u00a0% CI 1.33\u20132.48, p\u00a0<\u00a00.001). On multivariable analysis that adjusted for the effects of standard clinicopathologic variables, HER2 overexpression remained associated with disease recurrence (p\u00a0=\u00a00.04), overall (p\u00a0=\u00a00.02) and cancer-specific mortality (p\u00a0=\u00a00.02).ConclusionsApproximately, one-third of UTUC patients overexpressed HER2. HER2 overexpression was associated with features of clinically and biologically aggressive disease as well as prognosis. HER2 may represent a good marker for therapeutic risk stratification and potentially a target for therapy in some UTUC tumors.", 
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22 schema:description PurposeThe aim of our study was to evaluate the expression pattern of HER2 overexpression in patients with upper tract urothelial carcinoma (UTUC) and to evaluate its association with clinical outcomes.MethodsThis multicenter retrospective study included 732 patients treated with radical nephroureterectomy for UTUC. HER2 expression was assessed using immunohistochemistry and scored according to the HercepTest: Scores of 0 or 1 were considered negative and 2 or 3 as positive. To qualify for 2 scoring, complete membrane staining of more than 10 % of tumor cells at a moderate intensity had to be observed.ResultsHER2 was overexpressed in 262 (35.8 %) patients. It was associated with pathologic characteristics such as more advanced T stage (p < 0.001), presence of lymph node metastasis (p = 0.006), high-grade tumor (p < 0.001), tumor necrosis (p = 0.01) and lymphovascular invasion (p = 0.02). Patients with HER2 overexpression had a 1.66-fold increased risk of experiencing disease recurrence (95 % CI 1.24–2.24, p = 0.001), 1.55-fold increased risk of death (95 % CI 1.21–1.99, p = 0.001) and 1.81-fold increased risk of cancer-specific death (95 % CI 1.33–2.48, p < 0.001). On multivariable analysis that adjusted for the effects of standard clinicopathologic variables, HER2 overexpression remained associated with disease recurrence (p = 0.04), overall (p = 0.02) and cancer-specific mortality (p = 0.02).ConclusionsApproximately, one-third of UTUC patients overexpressed HER2. HER2 overexpression was associated with features of clinically and biologically aggressive disease as well as prognosis. HER2 may represent a good marker for therapeutic risk stratification and potentially a target for therapy in some UTUC tumors.
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365 Department of Urology, Weill Cornell Medical College, New York, NY, USA
366 rdf:type schema:Organization
367 grid-institutes:grid.8591.5 schema:alternateName Geneva Cancer Registry, Global Health Institute, University of Geneva, Geneva, Switzerland
368 schema:name Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria
369 Geneva Cancer Registry, Global Health Institute, University of Geneva, Geneva, Switzerland
370 rdf:type schema:Organization
 




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