Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12-11

AUTHORS

Aurélie Mbeutcha, Ilaria Lucca, Vitaly Margulis, Jose A. Karam, Christopher G. Wood, Michela de Martino, Romain Mathieu, Andrea Haitel, Evanguelos Xylinas, Luis Kluth, Morgan Rouprêt, Pierre I. Karakiewicz, Alberto Briganti, Michael Rink, Malte Rieken, Alon Z. Weizer, Jay D. Raman, Nathalie Rioux-Leclecq, Christian Bolenz, Karim Bensalah, Yair Lotan, Christian Seitz, Mesut Remzi, Shahrokh F. Shariat, Tobias Klatte

ABSTRACT

BackgroundExcision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.MethodsImmunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.ResultsERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).ConclusionsERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy. More... »

PAGES

1155-1161

Journal

TITLE

World Journal of Urology

ISSUE

8

VOLUME

34

Author Affiliations

  • Department of Urology, Hôpital Archet 2, Centre Hospitalier Universitaire de Nice, University of Nice Sophia-Antipolis, Nice, France
  • Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
  • Department of Urology, Vienna General Hospital, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria
  • Department of Urology, Rennes University Hospital, Rennes, France
  • Department of Pathology, Medical University of Vienna, Vienna, Austria
  • Department of Urology Cochin Hospital, APHP, Paris Descartes University, Paris, France
  • Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Urology, Pitié-Salpétrière, Assistance-Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France
  • Department of Urology, University of Montreal, Montreal, QC, Canada
  • Dipartimento di Urologia, Ospedale S. Raffaele, Università Vita-Salute, Milan, Italy
  • Department of Urology, University Hospital Basel, Basel, Switzerland
  • Department of Urology, University of Michigan, Ann Arbor, MI, USA
  • Division of Urology, Penn State Milton S.Hershey Medical Center, Hershey, PA, USA
  • Department of Pathology, University of Rennes, Rennes, France
  • Department of Urology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
  • Department of Urology, Landeskrankenhaus Weinviertel-Korneuburg, Korneuburg, Austria
  • Department of Urology, Weill Cornell Medical College, New York, NY, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00345-015-1737-7

    DOI

    http://dx.doi.org/10.1007/s00345-015-1737-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031491762

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26658888


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