Relationship between non-suspicious MRI and insignificant prostate cancer: results from a monocentric study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

Raphaële Renard-Penna, Morgan Roupret, Eva Compérat, François Rozet, Benjamin Granger, Johann Barkatz, Marc Olivier Bitker, Olivier Lucidarme, Olivier Cussenot, Pierre Mozer

ABSTRACT

OBJECTIVES: To assess whether non-suspicious multiparametric magnetic-resonance imaging (mpMRI) was associated with no cancer or indolent prostate cancer (PCa) in subsequent biopsies. PATIENTS AND METHODS: Retrospective analyses of a prospective database were conducted between 2009 and 2013. It included men with an abnormal digital rectal examination and/or prostate-specific antigen levels <20 ng/mL and a non-suspicious multiparametric MRI (Likert score <3). Participants underwent a systematic 12-extended-core biopsy ultrasound protocol (STD). Indolent PCa was defined as a single core with a Gleason score of 6 (3 + 3) and a cancer-core length of ≤4 mm. RESULTS: Seventy-eight patients with a negative MRI were included in the study; median patient age was 62 years (IQR 50-74). Median PSA level was 7.15 ng/mL, with a median PSA density of 0.15. The digital rectal examination was abnormal in eight cases. From MRI, 53 patients were Likert 2, 25 patients were Likert 1, and median prostate volume was 56.5 mL. From biopsies, no cancer was found in 92.3 % (n = 72). PCa was histologically confirmed in six patients (7.7 %): five cases were indolent (as defined above); only one patient had a cancer core of 5 mm long, with a Gleason score of 6 (3 + 3). All six patients were within the low-risk group according to the D'Amico classification. CONCLUSION: Men with non-suspicious mpMRI are likely to have no or indolent PCa in subsequent biopsies. More... »

PAGES

673-678

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-015-1685-2

DOI

http://dx.doi.org/10.1007/s00345-015-1685-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044272418

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26403663


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00345-015-1685-2'

Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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This table displays all metadata directly associated to this object as RDF triples.

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