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    "description": "Purpose\nWe created a prognostic tool for the prediction of oncologic outcomes after radical nephroureterectomy (RNU) for high-grade non-metastatic upper tract urothelial carcinoma (UTUC).MethodsUTUC collaboration was utilized to include 586 patients who underwent RNU for non-metastatic high-grade UTUC. Survival outcomes were compared according to a score defined based on the sum of the independent prognostic variables.ResultsThe study included 382 males with a median age 70\u00a0years (range 28\u201397). Independent prognostic factors included: T (t stage), A (architecture), LVI (lympho-vascular invasion) and L (lymphadenectomy). TALL score (1\u20137) was the sum of T (\u2264T1\u00a0=\u00a01, T2\u00a0=\u00a02, T3\u00a0=\u00a03 and T4\u00a0=\u00a04), A (papillary\u00a0=\u00a00 and sessile\u00a0=\u00a01), LVI (absent\u00a0=\u00a00 and present\u00a0=\u00a01) and L (lymphadenectomy\u00a0=\u00a00 and no lymphadenectomy\u00a0=\u00a01). Five-year disease-free survival (DFS) and cancer-specific survival (CSS) were stratified into four risk categories according to the TALL score: low (TALL 0\u20132; 86\u00a0% DFS and 90\u00a0% CSS), intermediate (TALL\u00a0=\u00a03; 71\u00a0% DFS and 75\u00a0% CSS), high (TALL\u00a0=\u00a04; 57\u00a0% DFS and 58\u00a0% CSS) and very high risk (TALL\u00a0\u2265\u00a05; 34\u00a0% DFS and 38\u00a0% CSS) using Kaplan\u2013Meier survival analyses. TALL score was externally validated in a single-center cohort of 85 UTUC patients.ConclusionsWe developed a multivariable prognostic tool for the prediction of oncological outcomes after RNU for high-grade UTUC. The score can be used for patient counseling, selection for adjuvant systemic therapies and design of clinical trials.", 
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