Role of metastasectomy for metastatic renal cell carcinoma in the era of targeted therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04-18

AUTHORS

Dae Y. Kim, Jose A. Karam, Christopher G. Wood

ABSTRACT

Numerous biological pathways are affected in renal cell carcinoma and the introduction of targeted agents has improved the survival of patients with advanced and metastatic disease. Durable and long-lasting cure is rarely achieved, and in select cases, the excision of metastatic deposits has shown to increase survival. Clinical trials of targeted agents are being explored as neoadjuvant and adjuvant therapies with the role of metastasectomy evolving in the treatment paradigm. This review examines published reports of metastasectomy and its developing role in the era of targeted therapy. A Medline search was conducted using keywords “metastasectomy,” “renal cell carcinoma,” and “targeted therapy,” and selected articles are discussed by examining prognostic stratification and metastasectomy in major anatomic regions. Most published reports span earlier periods of immunotherapy and chemotherapy, and henceforth, discussions are in historical context in this review. Although there is lack of Level 1 evidence, reports have suggested the prognostic value and survival benefit for metastasectomy in lesions that are amenable to complete resection after longer disease-free intervals in carefully selected patients with adequate performance status. Therefore, the role of metastasectomy must be further elucidated in the era of targeted therapy. More... »

PAGES

631-642

References to SciGraph publications

  • 2011-02-23. Surgical Treatment of Renal Cell Cancer Liver Metastases: A Population-Based Study in ANNALS OF SURGICAL ONCOLOGY
  • 2011-05-10. Pulmonary metastasectomy in patients with renal cell carcinoma: a single-institution experience in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2011-11-24. Treatment of colorectal liver metastases in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 1988-12. Metastatic patterns of renal carcinoma: An analysis of 687 necropsies in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2011-04-08. The role of metastasectomy in metastatic renal cell carcinoma in NATURE REVIEWS UROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00345-014-1293-6

    DOI

    http://dx.doi.org/10.1007/s00345-014-1293-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024584039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24744223


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