Ontology type: schema:ScholarlyArticle
2013-02
AUTHORSHarun Fajkovic, Eugene K. Cha, Evanguelos Xylinas, Michael Rink, Armin Pycha, Christian Seitz, Christian Bolenz, Allison Dunning, Giacomo Novara, Quoc-Dien Trinh, Pierre I. Karakiewicz, Vitaly Margulis, Jay D. Raman, Thomas J. Walton, Shiro Baba, Joaquin Carballido, Wolfgang Otto, Francesco Montorsi, Yair Lotan, Wassim Kassouf, Hans-Martin Fritsche, Karim Bensalah, Richard Zigeuner, Douglas S. Scherr, Guru Sonpavde, Morgan Roupret, Shahrokh F. Shariat
ABSTRACTOBJECTIVES: The primary endpoint in trials of perioperative systemic therapy for urothelial carcinoma is 5-year overall survival (OS). A shorter-term endpoint could significantly speed the translation of advances into practice. We hypothesized that disease-free survival (DFS) could be a surrogate endpoint for OS in upper tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU). PATIENTS AND METHODS: The study included 2,492 patients treated with RNU with curative intent for UTUC. RESULTS: 2/3-year DFS estimates were 78/73 %, and the 5-year OS estimate was 64 %. The overall agreements between 2- and 3-year DFS with 5-year OS were 85 and 87 %, respectively. Agreements were similar when analyzed in subgroups stratified by pathological stages, lymph node status, and adjuvant chemotherapy. The kappa statistic was 0.59 (95 % CI 0.55-0.63) for 2-year DFS/5-year OS and 0.64 (95 % CI 0.61-0.68) for 3-year DFS/5-year OS, indicating moderate reliability. The hazard ratio for DFS as a time-dependent variable for predicting OS was 11.5 (95 % CI 9.1-14.4), indicating a strong relationship between DFS and OS. CONCLUSIONS: In patients treated with RNU for UTUC, DFS and OS are highly correlated, regardless of tumor stage and adjuvant chemotherapy. While significant differences in DFS, assessed at 2 and 3 years, are highly likely to persist in OS at 5 years, marginal DFS advantages may not translate into OS benefit. External validation is necessary before accepting DFS as an appropriate surrogate endpoint for clinical trials investigating advanced UTUC patients. More... »
PAGES5-11
http://scigraph.springernature.com/pub.10.1007/s00345-012-0939-5
DOIhttp://dx.doi.org/10.1007/s00345-012-0939-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012976007
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23011256
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Transitional Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney Pelvis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nephrectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ureter",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ureteral Neoplasms",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA",
"General Hospital St. Poelten, St. Poelten, Austria"
],
"type": "Organization"
},
"familyName": "Fajkovic",
"givenName": "Harun",
"id": "sg:person.01034512743.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034512743.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Cha",
"givenName": "Eugene K.",
"id": "sg:person.01103103027.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103103027.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA",
"Department of Urology, Cochin Hospital, APHP, Paris Descartes University, Paris, France"
],
"type": "Organization"
},
"familyName": "Xylinas",
"givenName": "Evanguelos",
"id": "sg:person.01233162246.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233162246.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Medical Center Hamburg-Eppendorf",
"id": "https://www.grid.ac/institutes/grid.13648.38",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA",
"University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
],
"type": "Organization"
},
"familyName": "Rink",
"givenName": "Michael",
"id": "sg:person.0715216436.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715216436.18"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"General Hospital of Bolzano, Bolzano, Italy"
],
"type": "Organization"
},
"familyName": "Pycha",
"givenName": "Armin",
"id": "sg:person.0751464473.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751464473.28"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"General Hospital of Bolzano, Bolzano, Italy"
],
"type": "Organization"
},
"familyName": "Seitz",
"givenName": "Christian",
"id": "sg:person.0736135664.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736135664.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Mannheim Medical Center, University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Bolenz",
"givenName": "Christian",
"id": "sg:person.0646552740.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646552740.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Dunning",
"givenName": "Allison",
"id": "sg:person.0623406273.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623406273.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Padua",
"id": "https://www.grid.ac/institutes/grid.5608.b",
"name": [
"University of Padua, Padua, Italy"
],
"type": "Organization"
},
"familyName": "Novara",
"givenName": "Giacomo",
"id": "sg:person.01114636364.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114636364.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Montreal",
"id": "https://www.grid.ac/institutes/grid.14848.31",
"name": [
"University of Montreal, Montreal, QC, Canada"
],
"type": "Organization"
},
"familyName": "Trinh",
"givenName": "Quoc-Dien",
"id": "sg:person.0777221427.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777221427.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Montreal",
"id": "https://www.grid.ac/institutes/grid.14848.31",
"name": [
"University of Montreal, Montreal, QC, Canada"
],
"type": "Organization"
},
"familyName": "Karakiewicz",
"givenName": "Pierre I.",
"id": "sg:person.0717124312.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717124312.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas Southwestern Medical Center",
"id": "https://www.grid.ac/institutes/grid.267313.2",
"name": [
"University of Texas Southwestern Medical Center, Dallas, TX, USA"
],
"type": "Organization"
},
"familyName": "Margulis",
"givenName": "Vitaly",
"id": "sg:person.0700013535.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700013535.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Penn State Milton S. Hershey Medical Center",
"id": "https://www.grid.ac/institutes/grid.240473.6",
"name": [
"Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"
],
"type": "Organization"
},
"familyName": "Raman",
"givenName": "Jay D.",
"id": "sg:person.01162751564.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162751564.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Walton",
"givenName": "Thomas J.",
"id": "sg:person.0675033427.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675033427.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kitasato University",
"id": "https://www.grid.ac/institutes/grid.410786.c",
"name": [
"Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan"
],
"type": "Organization"
},
"familyName": "Baba",
"givenName": "Shiro",
"id": "sg:person.012200611232.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012200611232.31"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Carballido",
"givenName": "Joaquin",
"id": "sg:person.01153763300.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153763300.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Regensburg",
"id": "https://www.grid.ac/institutes/grid.7727.5",
"name": [
"Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany"
],
"type": "Organization"
},
"familyName": "Otto",
"givenName": "Wolfgang",
"id": "sg:person.01307210666.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307210666.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vita-Salute San Raffaele University",
"id": "https://www.grid.ac/institutes/grid.15496.3f",
"name": [
"Vita-Salute University, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Montorsi",
"givenName": "Francesco",
"id": "sg:person.01320375645.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320375645.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas Southwestern Medical Center",
"id": "https://www.grid.ac/institutes/grid.267313.2",
"name": [
"University of Texas Southwestern Medical Center, Dallas, TX, USA"
],
"type": "Organization"
},
"familyName": "Lotan",
"givenName": "Yair",
"id": "sg:person.01004736112.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004736112.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "McGill University",
"id": "https://www.grid.ac/institutes/grid.14709.3b",
"name": [
"McGill University, Montreal, QC, Canada"
],
"type": "Organization"
},
"familyName": "Kassouf",
"givenName": "Wassim",
"id": "sg:person.01261265212.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261265212.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Regensburg",
"id": "https://www.grid.ac/institutes/grid.7727.5",
"name": [
"Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany"
],
"type": "Organization"
},
"familyName": "Fritsche",
"givenName": "Hans-Martin",
"id": "sg:person.01253566422.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253566422.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "l'H\u00f4pital Pontchaillou",
"id": "https://www.grid.ac/institutes/grid.414271.5",
"name": [
"CHU Pontchaillou, Rennes, France"
],
"type": "Organization"
},
"familyName": "Bensalah",
"givenName": "Karim",
"id": "sg:person.01070707443.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070707443.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medical University of Graz",
"id": "https://www.grid.ac/institutes/grid.11598.34",
"name": [
"Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Zigeuner",
"givenName": "Richard",
"id": "sg:person.01224013051.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224013051.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Scherr",
"givenName": "Douglas S.",
"id": "sg:person.0670022464.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670022464.49"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Texas Oncology, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Sonpavde",
"givenName": "Guru",
"id": "sg:person.0766243700.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766243700.03"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France"
],
"type": "Organization"
},
"familyName": "Roupret",
"givenName": "Morgan",
"id": "sg:person.0740171455.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740171455.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NewYork\u2013Presbyterian Hospital",
"id": "https://www.grid.ac/institutes/grid.413734.6",
"name": [
"Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th St., Starr 900, 10065, New York, NY, USA",
"Division of Medical Oncology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Shariat",
"givenName": "Shahrokh F.",
"id": "sg:person.01260166612.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260166612.12"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00345-011-0710-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007682183",
"https://doi.org/10.1007/s00345-011-0710-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2010.09.110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011724159"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.urology.2010.04.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017090424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2011.12.055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019292350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2012.01.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019720299"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2009.05.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019932232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2009.02.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023731612"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4757-3656-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032089040",
"https://doi.org/10.1007/978-1-4757-3656-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4757-3656-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032089040",
"https://doi.org/10.1007/978-1-4757-3656-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4757-3656-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032089040",
"https://doi.org/10.1007/978-1-4757-3656-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.24135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033669387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2012.04.052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035728411"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0962280207081863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036257335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0962280207081863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036257335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.25050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038648333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.25050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038648333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.urology.2009.10.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045084939"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2012.07.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046581140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2006.10.4323",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049267041"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199812000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199812000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199812000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122727"
],
"type": "CreativeWork"
}
],
"datePublished": "2013-02",
"datePublishedReg": "2013-02-01",
"description": "OBJECTIVES: The primary endpoint in trials of perioperative systemic therapy for urothelial carcinoma is 5-year overall survival (OS). A shorter-term endpoint could significantly speed the translation of advances into practice. We hypothesized that disease-free survival (DFS) could be a surrogate endpoint for OS in upper tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU).\nPATIENTS AND METHODS: The study included 2,492 patients treated with RNU with curative intent for UTUC.\nRESULTS: 2/3-year DFS estimates were 78/73\u00a0%, and the 5-year OS estimate was 64\u00a0%. The overall agreements between 2- and 3-year DFS with 5-year OS were 85 and 87\u00a0%, respectively. Agreements were similar when analyzed in subgroups stratified by pathological stages, lymph node status, and adjuvant chemotherapy. The kappa statistic was 0.59 (95\u00a0% CI 0.55-0.63) for 2-year DFS/5-year OS and 0.64 (95\u00a0% CI 0.61-0.68) for 3-year DFS/5-year OS, indicating moderate reliability. The hazard ratio for DFS as a time-dependent variable for predicting OS was 11.5 (95\u00a0% CI 9.1-14.4), indicating a strong relationship between DFS and OS.\nCONCLUSIONS: In patients treated with RNU for UTUC, DFS and OS are highly correlated, regardless of tumor stage and adjuvant chemotherapy. While significant differences in DFS, assessed at 2 and 3\u00a0years, are highly likely to persist in OS at 5\u00a0years, marginal DFS advantages may not translate into OS benefit. External validation is necessary before accepting DFS as an appropriate surrogate endpoint for clinical trials investigating advanced UTUC patients.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00345-012-0939-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1094127",
"issn": [
"0724-4983",
"1433-8726"
],
"name": "World Journal of Urology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"name": "Disease-free survival as a surrogate for overall survival in upper tract urothelial carcinoma",
"pagination": "5-11",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3dd19cd21890ce04bdedd9ef5bbd4c1a74336180f325bbe74e608c2d3587e9c8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23011256"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8307716"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00345-012-0939-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012976007"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00345-012-0939-5",
"https://app.dimensions.ai/details/publication/pub.1012976007"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000480.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00345-012-0939-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00345-012-0939-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00345-012-0939-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00345-012-0939-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00345-012-0939-5'
This table displays all metadata directly associated to this object as RDF triples.
427 TRIPLES
21 PREDICATES
63 URIs
39 LITERALS
27 BLANK NODES