Pathological findings and oncological control afforded by radical prostatectomy in men with high-risk prostate cancer: a single-centre study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Alexandra Masson-Lecomte, Vincent Hupertan, Eva Comperat, Christophe Vaessen, Emmanuel Chartier-Kastler, Olivier Cussenot, Marc-Olivier Bitker, Morgan Rouprêt

ABSTRACT

OBJECTIVE: To assess pathological findings and oncological control afforded by radical prostatectomy (RP) in high-risk prostate cancers (PCa) at our institution. MATERIALS AND METHODS: We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2006 for a high-risk prostate cancer (i.e., PSA >20 or biopsy Gleason ≥8 or clinical stage ≥T2c). Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery. Survival curves were elaborated by the Kaplan-Meier method and Cox proportional hazard regression analysis. For each patient, a prognostic score for recurrence was estimated, and a prediction model was then constructed. RESULTS: Overall, 138 patients were included and followed for a median time of 53 months. Mean age at diagnosis was 63.4 years (range 39-80) and mean pre-operative PSA was 15.5 ng/ml (range 7.4-31). The median follow-up was 53 months (range 6-166). Overall, 82 patients (59%) had biochemical recurrence. The five-year PSA recurrence-free survival rate was 40%. In univariate analysis, clinically palpable tumours (T2-T3) (P = 0.032), biopsy Gleason score ≥8 (P = 0.031), seminal vesicle invasion (pT3b), positive margins and positive lymph nodes (P < 0.001) were significantly associated with recurrence. In multivariate analysis, the biopsy Gleason score ≥8, seminal vesicle invasion, positive margins and positive lymph nodes predicted recurrence (P < 0.05). CONCLUSIONS: RP affords an acceptable oncological control at first-line treatment of selected patients with high-risk PCa. However, in certain cases, surgery alone might not be sufficient and may be part of a multimodal treatment including either adjuvant radiotherapy or androgen deprivation. More... »

PAGES

665-670

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-010-0608-5

DOI

http://dx.doi.org/10.1007/s00345-010-0608-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028580414

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21072635


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masson-Lecomte", 
        "givenName": "Alexandra", 
        "id": "sg:person.01226772576.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226772576.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hupertan", 
        "givenName": "Vincent", 
        "id": "sg:person.01212572710.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212572710.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Comperat", 
        "givenName": "Eva", 
        "id": "sg:person.0640702012.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640702012.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaessen", 
        "givenName": "Christophe", 
        "id": "sg:person.0626212770.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626212770.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chartier-Kastler", 
        "givenName": "Emmanuel", 
        "id": "sg:person.01075107345.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107345.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cussenot", 
        "givenName": "Olivier", 
        "id": "sg:person.013241233644.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241233644.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bitker", 
        "givenName": "Marc-Olivier", 
        "id": "sg:person.01173307220.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173307220.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "The Academic Department of Urology, Pathology and Statistics of La Piti\u00e9-Salp\u00e9tri\u00e8re, Groupe Hospitalo-Universitaire EST, Assistance-Publique H\u00f4pitaux de Paris, 47-83 bvd de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Facult\u00e9 de M\u00e9decine Pierre et Marie Curie, University Paris VI, Paris, France", 
            "CeRePP group, Centre d\u2019Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roupr\u00eat", 
        "givenName": "Morgan", 
        "id": "sg:person.0740171455.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740171455.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003575529", 
          "https://doi.org/10.1038/nrclinonc.2010.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003575529", 
          "https://doi.org/10.1038/nrclinonc.2010.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2007.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007844513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.280.11.969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008293054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa074311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008325295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.7423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009668864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000134888.22332.bb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013349300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000134888.22332.bb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013349300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000134888.22332.bb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013349300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000140277.08623.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014458991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000140277.08623.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014458991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000140277.08623.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014458991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.08473.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014660266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2006.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015400119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0419-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015772803", 
          "https://doi.org/10.1007/s00345-009-0419-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0419-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015772803", 
          "https://doi.org/10.1007/s00345-009-0419-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0419-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015772803", 
          "https://doi.org/10.1007/s00345-009-0419-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.10.766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016489321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2006.08.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017890571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0810084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021611495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022825825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2008.08208.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024600438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)09408-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030068577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.09080.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030612641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.09080.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030612641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyp130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030763773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyp130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030763773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2451061502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031097744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031124508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2008.06.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035289825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2006.06452.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035884880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(02)80309-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043706438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-008-0247-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045028154", 
          "https://doi.org/10.1007/s00345-008-0247-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-008-0247-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045028154", 
          "https://doi.org/10.1007/s00345-008-0247-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70700-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048558719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006019.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048563501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000154610.81916.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000154610.81916.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000154610.81916.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.01.086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.3134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.3134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)42876-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079710128"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10", 
    "datePublishedReg": "2011-10-01", 
    "description": "OBJECTIVE: To assess pathological findings and oncological control afforded by radical prostatectomy (RP) in high-risk prostate cancers (PCa) at our institution.\nMATERIALS AND METHODS: We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2006 for a high-risk prostate cancer (i.e., PSA >20 or biopsy Gleason \u22658 or clinical stage \u2265T2c). Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery. Survival curves were elaborated by the Kaplan-Meier method and Cox proportional hazard regression analysis. For each patient, a prognostic score for recurrence was estimated, and a prediction model was then constructed.\nRESULTS: Overall, 138 patients were included and followed for a median time of 53 months. Mean age at diagnosis was 63.4 years (range 39-80) and mean pre-operative PSA was 15.5 ng/ml (range 7.4-31). The median follow-up was 53 months (range 6-166). Overall, 82 patients (59%) had biochemical recurrence. The five-year PSA recurrence-free survival rate was 40%. In univariate analysis, clinically palpable tumours (T2-T3) (P = 0.032), biopsy Gleason score \u22658 (P = 0.031), seminal vesicle invasion (pT3b), positive margins and positive lymph nodes (P < 0.001) were significantly associated with recurrence. In multivariate analysis, the biopsy Gleason score \u22658, seminal vesicle invasion, positive margins and positive lymph nodes predicted recurrence (P < 0.05).\nCONCLUSIONS: RP affords an acceptable oncological control at first-line treatment of selected patients with high-risk PCa. However, in certain cases, surgery alone might not be sufficient and may be part of a multimodal treatment including either adjuvant radiotherapy or androgen deprivation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00345-010-0608-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094127", 
        "issn": [
          "0724-4983", 
          "1433-8726"
        ], 
        "name": "World Journal of Urology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Pathological findings and oncological control afforded by radical prostatectomy in men with high-risk prostate cancer: a single-centre study", 
    "pagination": "665-670", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "88261c5c084e0ac85179edd85dbc9cd8e38f7dd63fb39098b597e83987ebc075"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21072635"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8307716"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00345-010-0608-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028580414"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00345-010-0608-5", 
      "https://app.dimensions.ai/details/publication/pub.1028580414"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000489.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00345-010-0608-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00345-010-0608-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00345-010-0608-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00345-010-0608-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00345-010-0608-5'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      70 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00345-010-0608-5 schema:about N107427e655c44488a8bd7f88a172804e
2 N211ff577ec694c44bb540e92071acd61
3 N53280922768442988479df2ec62f6966
4 N58be598212724e48afc74b6f0ff03584
5 N737bc7c0b7244a83a34de5806a9372ba
6 N851cac517c5b4f74ac8fb7596cb4599f
7 N905f410155614042a61f932d39e3aa47
8 Naf8c1242d96e44f0a60cd16acece7826
9 Ned19e47df416408497c8504f04d1bb03
10 Nee67ff0c547947668eb4fea377fcfae3
11 Nf74addb38cdf457b8b161894dff1c503
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N654ab55812ec481289c65a39e8ae0d69
15 schema:citation sg:pub.10.1007/s00345-008-0247-2
16 sg:pub.10.1007/s00345-009-0419-8
17 sg:pub.10.1038/nrclinonc.2010.63
18 https://doi.org/10.1001/jama.280.11.969
19 https://doi.org/10.1002/14651858.cd006019.pub2
20 https://doi.org/10.1016/j.eururo.2007.10.009
21 https://doi.org/10.1016/j.eururo.2008.06.059
22 https://doi.org/10.1016/j.juro.2006.06.017
23 https://doi.org/10.1016/j.juro.2006.08.057
24 https://doi.org/10.1016/s0022-5347(02)80309-3
25 https://doi.org/10.1016/s0022-5347(17)42876-x
26 https://doi.org/10.1016/s0140-6736(02)09408-4
27 https://doi.org/10.1016/s1470-2045(06)70700-8
28 https://doi.org/10.1056/nejmoa074311
29 https://doi.org/10.1056/nejmoa0810084
30 https://doi.org/10.1093/jjco/hyp130
31 https://doi.org/10.1093/jnci/90.10.766
32 https://doi.org/10.1097/01.ju.0000134888.22332.bb
33 https://doi.org/10.1097/01.ju.0000140277.08623.13
34 https://doi.org/10.1097/01.ju.0000154610.81916.81
35 https://doi.org/10.1111/j.1464-410x.2006.06452.x
36 https://doi.org/10.1111/j.1464-410x.2008.08208.x
37 https://doi.org/10.1111/j.1464-410x.2009.08473.x
38 https://doi.org/10.1111/j.1464-410x.2009.09080.x
39 https://doi.org/10.1148/radiol.2451061502
40 https://doi.org/10.1200/jco.2002.01.086
41 https://doi.org/10.1200/jco.2005.01.867
42 https://doi.org/10.1200/jco.2005.03.3134
43 https://doi.org/10.1200/jco.2005.04.7423
44 https://doi.org/10.3322/caac.20006
45 schema:datePublished 2011-10
46 schema:datePublishedReg 2011-10-01
47 schema:description OBJECTIVE: To assess pathological findings and oncological control afforded by radical prostatectomy (RP) in high-risk prostate cancers (PCa) at our institution. MATERIALS AND METHODS: We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2006 for a high-risk prostate cancer (i.e., PSA >20 or biopsy Gleason ≥8 or clinical stage ≥T2c). Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery. Survival curves were elaborated by the Kaplan-Meier method and Cox proportional hazard regression analysis. For each patient, a prognostic score for recurrence was estimated, and a prediction model was then constructed. RESULTS: Overall, 138 patients were included and followed for a median time of 53 months. Mean age at diagnosis was 63.4 years (range 39-80) and mean pre-operative PSA was 15.5 ng/ml (range 7.4-31). The median follow-up was 53 months (range 6-166). Overall, 82 patients (59%) had biochemical recurrence. The five-year PSA recurrence-free survival rate was 40%. In univariate analysis, clinically palpable tumours (T2-T3) (P = 0.032), biopsy Gleason score ≥8 (P = 0.031), seminal vesicle invasion (pT3b), positive margins and positive lymph nodes (P < 0.001) were significantly associated with recurrence. In multivariate analysis, the biopsy Gleason score ≥8, seminal vesicle invasion, positive margins and positive lymph nodes predicted recurrence (P < 0.05). CONCLUSIONS: RP affords an acceptable oncological control at first-line treatment of selected patients with high-risk PCa. However, in certain cases, surgery alone might not be sufficient and may be part of a multimodal treatment including either adjuvant radiotherapy or androgen deprivation.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N453e51e93ed243f29e4f7067fa679535
52 Nfc4486e0c82a4f1499b504016d377fba
53 sg:journal.1094127
54 schema:name Pathological findings and oncological control afforded by radical prostatectomy in men with high-risk prostate cancer: a single-centre study
55 schema:pagination 665-670
56 schema:productId N107466c39e6c4ebda876a7ad2bd48745
57 Nb01ac19efa7b4e19bd61d1ec8053a472
58 Nb599dd8f53334cf3b403939c79f0e974
59 Nc35e6ee7e8154d4f85d15a3f6dc90b29
60 Nf2f5d463df384d97ae17163368b29f20
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028580414
62 https://doi.org/10.1007/s00345-010-0608-5
63 schema:sdDatePublished 2019-04-10T21:31
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N985019e90b794804b2aae549b9c4b23b
66 schema:url http://link.springer.com/10.1007/s00345-010-0608-5
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0e020092f2d54b33891f407f72fa1f30 rdf:first sg:person.0640702012.02
71 rdf:rest N3207751c0cb948b890182d8367c308a2
72 N107427e655c44488a8bd7f88a172804e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Aged
74 rdf:type schema:DefinedTerm
75 N107466c39e6c4ebda876a7ad2bd48745 schema:name dimensions_id
76 schema:value pub.1028580414
77 rdf:type schema:PropertyValue
78 N211ff577ec694c44bb540e92071acd61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Adult
80 rdf:type schema:DefinedTerm
81 N3207751c0cb948b890182d8367c308a2 rdf:first sg:person.0626212770.19
82 rdf:rest N7ca61d22164640d69e34f528bd33382c
83 N453e51e93ed243f29e4f7067fa679535 schema:issueNumber 5
84 rdf:type schema:PublicationIssue
85 N52266c3df7ca443bb4b0aeafa4864046 rdf:first sg:person.013241233644.08
86 rdf:rest N7aec07d0ba9641b1b0673fc090288046
87 N53280922768442988479df2ec62f6966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Retrospective Studies
89 rdf:type schema:DefinedTerm
90 N58be598212724e48afc74b6f0ff03584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Prostatic Neoplasms
92 rdf:type schema:DefinedTerm
93 N654ab55812ec481289c65a39e8ae0d69 rdf:first sg:person.01226772576.78
94 rdf:rest Nfdbe56017b26473596b5759fc55dfa40
95 N737bc7c0b7244a83a34de5806a9372ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Aged, 80 and over
97 rdf:type schema:DefinedTerm
98 N7aec07d0ba9641b1b0673fc090288046 rdf:first sg:person.01173307220.15
99 rdf:rest Nb7acd21b69bf40dd80825063beabd5db
100 N7ca61d22164640d69e34f528bd33382c rdf:first sg:person.01075107345.46
101 rdf:rest N52266c3df7ca443bb4b0aeafa4864046
102 N851cac517c5b4f74ac8fb7596cb4599f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Prostatectomy
104 rdf:type schema:DefinedTerm
105 N905f410155614042a61f932d39e3aa47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Male
107 rdf:type schema:DefinedTerm
108 N985019e90b794804b2aae549b9c4b23b schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 Naf8c1242d96e44f0a60cd16acece7826 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Survival Rate
112 rdf:type schema:DefinedTerm
113 Nb01ac19efa7b4e19bd61d1ec8053a472 schema:name readcube_id
114 schema:value 88261c5c084e0ac85179edd85dbc9cd8e38f7dd63fb39098b597e83987ebc075
115 rdf:type schema:PropertyValue
116 Nb599dd8f53334cf3b403939c79f0e974 schema:name doi
117 schema:value 10.1007/s00345-010-0608-5
118 rdf:type schema:PropertyValue
119 Nb7acd21b69bf40dd80825063beabd5db rdf:first sg:person.0740171455.76
120 rdf:rest rdf:nil
121 Nc35e6ee7e8154d4f85d15a3f6dc90b29 schema:name nlm_unique_id
122 schema:value 8307716
123 rdf:type schema:PropertyValue
124 Ned19e47df416408497c8504f04d1bb03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Middle Aged
126 rdf:type schema:DefinedTerm
127 Nee67ff0c547947668eb4fea377fcfae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 Nf2f5d463df384d97ae17163368b29f20 schema:name pubmed_id
131 schema:value 21072635
132 rdf:type schema:PropertyValue
133 Nf74addb38cdf457b8b161894dff1c503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Treatment Outcome
135 rdf:type schema:DefinedTerm
136 Nfc4486e0c82a4f1499b504016d377fba schema:volumeNumber 29
137 rdf:type schema:PublicationVolume
138 Nfdbe56017b26473596b5759fc55dfa40 rdf:first sg:person.01212572710.23
139 rdf:rest N0e020092f2d54b33891f407f72fa1f30
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
144 schema:name Oncology and Carcinogenesis
145 rdf:type schema:DefinedTerm
146 sg:journal.1094127 schema:issn 0724-4983
147 1433-8726
148 schema:name World Journal of Urology
149 rdf:type schema:Periodical
150 sg:person.01075107345.46 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
151 schema:familyName Chartier-Kastler
152 schema:givenName Emmanuel
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107345.46
154 rdf:type schema:Person
155 sg:person.01173307220.15 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
156 schema:familyName Bitker
157 schema:givenName Marc-Olivier
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173307220.15
159 rdf:type schema:Person
160 sg:person.01212572710.23 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
161 schema:familyName Hupertan
162 schema:givenName Vincent
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212572710.23
164 rdf:type schema:Person
165 sg:person.01226772576.78 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
166 schema:familyName Masson-Lecomte
167 schema:givenName Alexandra
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226772576.78
169 rdf:type schema:Person
170 sg:person.013241233644.08 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
171 schema:familyName Cussenot
172 schema:givenName Olivier
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241233644.08
174 rdf:type schema:Person
175 sg:person.0626212770.19 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
176 schema:familyName Vaessen
177 schema:givenName Christophe
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626212770.19
179 rdf:type schema:Person
180 sg:person.0640702012.02 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
181 schema:familyName Comperat
182 schema:givenName Eva
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640702012.02
184 rdf:type schema:Person
185 sg:person.0740171455.76 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
186 schema:familyName Rouprêt
187 schema:givenName Morgan
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740171455.76
189 rdf:type schema:Person
190 sg:pub.10.1007/s00345-008-0247-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045028154
191 https://doi.org/10.1007/s00345-008-0247-2
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00345-009-0419-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015772803
194 https://doi.org/10.1007/s00345-009-0419-8
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nrclinonc.2010.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003575529
197 https://doi.org/10.1038/nrclinonc.2010.63
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1001/jama.280.11.969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008293054
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/14651858.cd006019.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048563501
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.eururo.2007.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007844513
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.eururo.2008.06.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035289825
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.juro.2006.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015400119
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.juro.2006.08.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017890571
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0022-5347(02)80309-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043706438
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0022-5347(17)42876-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079710128
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0140-6736(02)09408-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030068577
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s1470-2045(06)70700-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048558719
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejmoa074311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008325295
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejmoa0810084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611495
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/jjco/hyp130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030763773
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/jnci/90.10.766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016489321
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/01.ju.0000134888.22332.bb schema:sameAs https://app.dimensions.ai/details/publication/pub.1013349300
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1097/01.ju.0000140277.08623.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014458991
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/01.ju.0000154610.81916.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050983118
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/j.1464-410x.2006.06452.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035884880
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1464-410x.2008.08208.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024600438
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1464-410x.2009.08473.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014660266
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1464-410x.2009.09080.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030612641
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1148/radiol.2451061502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031097744
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1200/jco.2002.01.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202907
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1200/jco.2005.01.867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031124508
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1200/jco.2005.03.3134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204217
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1200/jco.2005.04.7423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009668864
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
252 rdf:type schema:CreativeWork
253 https://www.grid.ac/institutes/grid.462844.8 schema:alternateName Sorbonne University
254 schema:name CeRePP group, Centre d’Etudes et de Recherche sur les Pathologies Prostatiques, Paris, France
255 Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France
256 The Academic Department of Urology, Pathology and Statistics of La Pitié-Salpétrière, Groupe Hospitalo-Universitaire EST, Assistance-Publique Hôpitaux de Paris, 47-83 bvd de l’Hôpital, 75013, Paris, France
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...