Impact of oral anticoagulation on morbidity of transurethral resection of the prostate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06-25

AUTHORS

Aurélien Descazeaud, Gregoire Robert, Souhil Lebdai, Alain Bougault, Abdel Rahmene Azzousi, Olivier Haillot, Marian Devonec, Marc Fourmarier, Christian Saussine, Nicolas Barry-Delongchamps, Alexandre de la Taille

ABSTRACT

AimTo assess the impact of oral anticoagulation (OA) on morbidity of transurethral resection of the prostate (TURP). OA included warfarin and platelet aggregation inhibitors (PAI).Patients and MethodMulticenter analysis of patients operated for symptomatic benign prostatic hyperplasia (BPH) by TURP. Patients under OA were compared to those with no OA.ResultsOut of 612 patients included in the analysis, 206 (33%) were on OA prior surgery (55 warfarin, 142 PAI, and 9 warfarin and PAI). No patient continued warfarin and clopidogrel during the operating period. Patients under OA were significantly older (75 vs. 71 yo, P < 0.001), had larger prostate volume (56 vs. 49 ml, P = 0.05), and had higher rate of bladder catheter prior surgery (26 vs. 17%, P = 0.02). At 3 months follow-up, patients in the OA group had a higher weight of resected tissue (24 vs. 21.7 g, P < 0.001), a longer duration of hospitalization (6.4 vs. 4.7 days P < 0.001), a higher rate of bladder clots (13 vs. 4.7%, P < 0.001), red cell transfusion (1.9 vs. 1.0%, P = 0.026), late hematuria (15.0 vs. 8.4%, P = 0.004), and thromboembolic events (2.4 vs. 0.7, P = 0.02). In multivariable analysis, OA status was the sole independent parameter associated with bladder clots (P = 0.004) and with late hematuria (P = 0.03).ConclusionOA had a significant and independent impact on TURP outcome in terms of bleeding complications. This data could be used for treatment decision and for patient’s information prior BPH surgery. More... »

PAGES

211-216

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-010-0561-3

DOI

http://dx.doi.org/10.1007/s00345-010-0561-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014860569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20577744


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26 schema:description AimTo assess the impact of oral anticoagulation (OA) on morbidity of transurethral resection of the prostate (TURP). OA included warfarin and platelet aggregation inhibitors (PAI).Patients and MethodMulticenter analysis of patients operated for symptomatic benign prostatic hyperplasia (BPH) by TURP. Patients under OA were compared to those with no OA.ResultsOut of 612 patients included in the analysis, 206 (33%) were on OA prior surgery (55 warfarin, 142 PAI, and 9 warfarin and PAI). No patient continued warfarin and clopidogrel during the operating period. Patients under OA were significantly older (75 vs. 71 yo, P < 0.001), had larger prostate volume (56 vs. 49 ml, P = 0.05), and had higher rate of bladder catheter prior surgery (26 vs. 17%, P = 0.02). At 3 months follow-up, patients in the OA group had a higher weight of resected tissue (24 vs. 21.7 g, P < 0.001), a longer duration of hospitalization (6.4 vs. 4.7 days P < 0.001), a higher rate of bladder clots (13 vs. 4.7%, P < 0.001), red cell transfusion (1.9 vs. 1.0%, P = 0.026), late hematuria (15.0 vs. 8.4%, P = 0.004), and thromboembolic events (2.4 vs. 0.7, P = 0.02). In multivariable analysis, OA status was the sole independent parameter associated with bladder clots (P = 0.004) and with late hematuria (P = 0.03).ConclusionOA had a significant and independent impact on TURP outcome in terms of bleeding complications. This data could be used for treatment decision and for patient’s information prior BPH surgery.
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34 BPH surgery
35 ConclusionOA
36 MethodMulticenter analysis
37 OA group
38 OA prior surgery
39 OA status
40 ResultsOut
41 TURP
42 TURP outcomes
43 aggregation inhibitors
44 analysis
45 anticoagulation
46 benign prostatic hyperplasia
47 bladder catheter prior surgery
48 bladder clots
49 catheter prior surgery
50 cell transfusion
51 clopidogrel
52 clots
53 complications
54 continued warfarin
55 data
56 decisions
57 duration
58 events
59 group
60 hematuria
61 high rate
62 higher weight
63 hospitalization
64 hyperplasia
65 impact
66 independent impact
67 independent parameters
68 information
69 inhibitors
70 larger prostate volume
71 late hematuria
72 longer duration
73 months
74 morbidity
75 multivariable analysis
76 operating period
77 oral anticoagulation
78 outcomes
79 parameters
80 patient continued warfarin
81 patient information
82 patients
83 period
84 platelet aggregation inhibitors
85 prior surgery
86 prostate
87 prostate volume
88 prostatic hyperplasia
89 rate
90 red cell transfusion
91 resection
92 sole independent parameter
93 status
94 surgery
95 symptomatic benign prostatic hyperplasia
96 terms
97 thromboembolic events
98 tissue
99 transfusion
100 transurethral resection
101 treatment decisions
102 volume
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