Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03-15

AUTHORS

María T. Grande, Miguel Arévalo, Alejandro Núñez, Jorge B. Cannata-Andía, Eugenio Santos, José M. López-Novoa

ABSTRACT

PurposeTo assess the contribution of two different Ras monomeric GTPases isoforms H- and N-Ras in the early changes associated to obstructive nephropathy induced by unilateral ureteral obstruction (UUO).MethodsUUO was performed in N-ras (N-ras−/−) and H-ras (H-ras−/−) knock-out mice and control (H-ras+/+/N-ras+/+) mice of C57Bl/6 background. Fibronectin, α-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry. Ras isoforms activation and caspase activity were determined by both western blot and ELISA.ResultsThree days after UUO, obstructed (O) kidneys of H-ras−/−, N-ras−/− and H-ras+/+/N-ras+/+ mice showed no significant differences in activated total ras, pERK1/2, pAkt, total Akt levels, fibronectin, α-SMA expression, cell proliferation, and activated caspase-3. The morphological alterations in the O kidneys, revealed by histological and immunohistochemical studies, were also similar in H-ras−/−, N-ras−/−, and H-ras+/+/N-ras+/+ mice.ConclusionsThese data suggest that the activation of H-ras and N-ras isoforms does not play a major role in the early renal damage induced by UUO. More... »

PAGES

787

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8

DOI

http://dx.doi.org/10.1007/s00345-009-0399-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030097244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19288266


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Signal-Regulated MAP Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibronectins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ureter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ureteral Obstruction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Instituto \u201cReina Sof\u00eda\u201d de Investigaci\u00f3n Nefrol\u00f3gica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.11762.33", 
          "name": [
            "Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Instituto \u201cReina Sof\u00eda\u201d de Investigaci\u00f3n Nefrol\u00f3gica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grande", 
        "givenName": "Mar\u00eda T.", 
        "id": "sg:person.01111611561.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111611561.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento de Anatom\u00eda e Histolog\u00eda Humanas, Universidad de Salamanca, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.11762.33", 
          "name": [
            "Departamento de Anatom\u00eda e Histolog\u00eda Humanas, Universidad de Salamanca, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ar\u00e9valo", 
        "givenName": "Miguel", 
        "id": "sg:person.0743254021.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743254021.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-USAL, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428472.f", 
          "name": [
            "Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-USAL, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00fa\u00f1ez", 
        "givenName": "Alejandro", 
        "id": "sg:person.01235544044.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235544044.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mineral, Bone and Mineral Research Unit, Instituto Reina Sof\u00eda de Investigaci\u00f3n Nefrol\u00f3gica, Hospital Universitario Central de Asturias, Oviedo, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411052.3", 
          "name": [
            "Mineral, Bone and Mineral Research Unit, Instituto Reina Sof\u00eda de Investigaci\u00f3n Nefrol\u00f3gica, Hospital Universitario Central de Asturias, Oviedo, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannata-And\u00eda", 
        "givenName": "Jorge B.", 
        "id": "sg:person.01205721071.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205721071.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-USAL, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428472.f", 
          "name": [
            "Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-USAL, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santos", 
        "givenName": "Eugenio", 
        "id": "sg:person.01065110724.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065110724.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Instituto \u201cReina Sof\u00eda\u201d de Investigaci\u00f3n Nefrol\u00f3gica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.11762.33", 
          "name": [
            "Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Instituto \u201cReina Sof\u00eda\u201d de Investigaci\u00f3n Nefrol\u00f3gica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez-Novoa", 
        "givenName": "Jos\u00e9 M.", 
        "id": "sg:person.014102272764.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014102272764.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1201284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047596897", 
          "https://doi.org/10.1038/sj.onc.1201284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:appt.0000045801.15585.dd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020224719", 
          "https://doi.org/10.1023/b:appt.0000045801.15585.dd"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051703411", 
          "https://doi.org/10.1038/sj.onc.1202251"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-03-15", 
    "datePublishedReg": "2009-03-15", 
    "description": "PurposeTo assess the contribution of two different Ras monomeric GTPases isoforms H- and N-Ras in the early changes associated to obstructive nephropathy induced by unilateral ureteral obstruction (UUO).MethodsUUO was performed in N-ras (N-ras\u2212/\u2212) and H-ras (H-ras\u2212/\u2212) knock-out mice and control (H-ras+/+/N-ras+/+) mice of C57Bl/6 background. Fibronectin, \u03b1-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry. Ras isoforms activation and caspase activity were determined by both western blot and ELISA.ResultsThree days after UUO, obstructed (O) kidneys of H-ras\u2212/\u2212, N-ras\u2212/\u2212 and H-ras+/+/N-ras+/+ mice showed no significant differences in activated total ras, pERK1/2, pAkt, total Akt levels, fibronectin, \u03b1-SMA expression, cell proliferation, and activated caspase-3. The morphological alterations in the O kidneys, revealed by histological and immunohistochemical studies, were also similar in H-ras\u2212/\u2212, N-ras\u2212/\u2212, and H-ras+/+/N-ras+/+ mice.ConclusionsThese data suggest that the activation of H-ras and N-ras isoforms does not play a major role in the early renal damage induced by UUO.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00345-009-0399-8", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094127", 
        "issn": [
          "0724-4983", 
          "1433-8726"
        ], 
        "name": "World Journal of Urology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "keywords": [
      "unilateral ureteral obstruction", 
      "Western blot", 
      "early renal changes", 
      "early renal damage", 
      "unilateral ureteral ligation", 
      "N-ras", 
      "caspase-3", 
      "\u03b1-SMA expression", 
      "smooth muscle actin", 
      "total Akt levels", 
      "H-Ras", 
      "O kidneys", 
      "renal damage", 
      "renal changes", 
      "ureteral obstruction", 
      "control mice", 
      "ureteral ligation", 
      "immunohistochemical study", 
      "Ki-67", 
      "ConclusionsThese data", 
      "pAkt expression", 
      "muscle actin", 
      "ResultsThree days", 
      "early changes", 
      "Akt levels", 
      "mice", 
      "isoform activation", 
      "cell proliferation", 
      "morphological alterations", 
      "significant differences", 
      "kidney", 
      "total Ra", 
      "blot", 
      "caspase activity", 
      "activation", 
      "N-Ras isoforms", 
      "nephropathy", 
      "fibronectin", 
      "major role", 
      "PurposeTo", 
      "obstruction", 
      "genomic disruption", 
      "expression", 
      "immunohistochemistry", 
      "pAkt", 
      "ELISA", 
      "pERK1/2", 
      "Ras-GTP", 
      "ligation", 
      "proliferation", 
      "alterations", 
      "isoform H", 
      "days", 
      "PERK", 
      "changes", 
      "isoforms", 
      "RA", 
      "damage", 
      "disruption", 
      "actin", 
      "levels", 
      "differences", 
      "activity", 
      "study", 
      "background", 
      "role", 
      "effect", 
      "data", 
      "contribution"
    ], 
    "name": "Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation", 
    "pagination": "787", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030097244"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00345-009-0399-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19288266"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00345-009-0399-8", 
      "https://app.dimensions.ai/details/publication/pub.1030097244"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_479.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00345-009-0399-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      116 URIs      105 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00345-009-0399-8 schema:about N0110674bf243483eb4f3e0079f9f7303
2 N03222a5301b4418d9ed26f736c33da5a
3 N0c4f4708081046f6a8f71b4051c2df02
4 N12b22fca5ad54cf6bd5faad9a3731b3f
5 N1941aca1fa644e629013e81c15a41f1f
6 N3301e08102964541836429324e6ab216
7 N53a8aeaa5da24875b73477556476f047
8 N5dd42133bb62425ca440718f0944cff9
9 N5ece3840cf4041ecad2707f7f336662e
10 N610fdbed1361412ca238448fb1365f8c
11 N84342e60f63f4ea18f5257995f0302d7
12 N8e028bc7c9614ec7a74a6a102e896790
13 N9d78d08ff5684bd4bf2a0731bbb91494
14 N9ef47e05cc274f15aefa8ad89be66904
15 Nb804718882684af6820312816a177b1f
16 Nc2c0fadee300434db19334ae96fab817
17 Nc494f5ebc74c44ce914453901673ef3b
18 Ne3f0753734f648d08f67ffe9b2e531b1
19 Nfd13e01452784aab8fc0bc78310ec17f
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author Nf225695cc3c741b7adf93e6b5432a5b3
23 schema:citation sg:pub.10.1023/b:appt.0000045801.15585.dd
24 sg:pub.10.1038/sj.onc.1201284
25 sg:pub.10.1038/sj.onc.1202251
26 schema:datePublished 2009-03-15
27 schema:datePublishedReg 2009-03-15
28 schema:description PurposeTo assess the contribution of two different Ras monomeric GTPases isoforms H- and N-Ras in the early changes associated to obstructive nephropathy induced by unilateral ureteral obstruction (UUO).MethodsUUO was performed in N-ras (N-ras−/−) and H-ras (H-ras−/−) knock-out mice and control (H-ras+/+/N-ras+/+) mice of C57Bl/6 background. Fibronectin, α-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry. Ras isoforms activation and caspase activity were determined by both western blot and ELISA.ResultsThree days after UUO, obstructed (O) kidneys of H-ras−/−, N-ras−/− and H-ras+/+/N-ras+/+ mice showed no significant differences in activated total ras, pERK1/2, pAkt, total Akt levels, fibronectin, α-SMA expression, cell proliferation, and activated caspase-3. The morphological alterations in the O kidneys, revealed by histological and immunohistochemical studies, were also similar in H-ras−/−, N-ras−/−, and H-ras+/+/N-ras+/+ mice.ConclusionsThese data suggest that the activation of H-ras and N-ras isoforms does not play a major role in the early renal damage induced by UUO.
29 schema:genre article
30 schema:isAccessibleForFree false
31 schema:isPartOf N04c7c6e925b74d70960ae20471a95db2
32 Nce5d2da509fe48398df04709c87e0595
33 sg:journal.1094127
34 schema:keywords Akt levels
35 ConclusionsThese data
36 ELISA
37 H-Ras
38 Ki-67
39 N-Ras isoforms
40 N-ras
41 O kidneys
42 PERK
43 PurposeTo
44 RA
45 Ras-GTP
46 ResultsThree days
47 Western blot
48 actin
49 activation
50 activity
51 alterations
52 background
53 blot
54 caspase activity
55 caspase-3
56 cell proliferation
57 changes
58 contribution
59 control mice
60 damage
61 data
62 days
63 differences
64 disruption
65 early changes
66 early renal changes
67 early renal damage
68 effect
69 expression
70 fibronectin
71 genomic disruption
72 immunohistochemical study
73 immunohistochemistry
74 isoform H
75 isoform activation
76 isoforms
77 kidney
78 levels
79 ligation
80 major role
81 mice
82 morphological alterations
83 muscle actin
84 nephropathy
85 obstruction
86 pAkt
87 pAkt expression
88 pERK1/2
89 proliferation
90 renal changes
91 renal damage
92 role
93 significant differences
94 smooth muscle actin
95 study
96 total Akt levels
97 total Ra
98 unilateral ureteral ligation
99 unilateral ureteral obstruction
100 ureteral ligation
101 ureteral obstruction
102 α-SMA expression
103 schema:name Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation
104 schema:pagination 787
105 schema:productId N0c986eac3e0c4bacac92aa609fd470f3
106 N66a517b2ee9b47b0b2fb96ba04d902dc
107 Nf8a3d8e168284976839ab17c010eeaa1
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030097244
109 https://doi.org/10.1007/s00345-009-0399-8
110 schema:sdDatePublished 2022-10-01T06:35
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N171d98711c0b47eabb89ee502838d027
113 schema:url https://doi.org/10.1007/s00345-009-0399-8
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N0110674bf243483eb4f3e0079f9f7303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Genome
119 rdf:type schema:DefinedTerm
120 N03222a5301b4418d9ed26f736c33da5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mice, Knockout
122 rdf:type schema:DefinedTerm
123 N04c7c6e925b74d70960ae20471a95db2 schema:volumeNumber 27
124 rdf:type schema:PublicationVolume
125 N0c4f4708081046f6a8f71b4051c2df02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Kidney
127 rdf:type schema:DefinedTerm
128 N0c986eac3e0c4bacac92aa609fd470f3 schema:name doi
129 schema:value 10.1007/s00345-009-0399-8
130 rdf:type schema:PropertyValue
131 N0e0d2c44ad2844a7af244b3c8cbac1a2 rdf:first sg:person.01205721071.24
132 rdf:rest Nb15d160051e84b8d99e51c4214623064
133 N12b22fca5ad54cf6bd5faad9a3731b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Male
135 rdf:type schema:DefinedTerm
136 N171d98711c0b47eabb89ee502838d027 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N1941aca1fa644e629013e81c15a41f1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Disease Models, Animal
140 rdf:type schema:DefinedTerm
141 N3301e08102964541836429324e6ab216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Extracellular Signal-Regulated MAP Kinases
143 rdf:type schema:DefinedTerm
144 N53a8aeaa5da24875b73477556476f047 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Proto-Oncogene Proteins c-akt
146 rdf:type schema:DefinedTerm
147 N5dd42133bb62425ca440718f0944cff9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Fibronectins
149 rdf:type schema:DefinedTerm
150 N5ece3840cf4041ecad2707f7f336662e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Animals
152 rdf:type schema:DefinedTerm
153 N610fdbed1361412ca238448fb1365f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Fibrosis
155 rdf:type schema:DefinedTerm
156 N66a517b2ee9b47b0b2fb96ba04d902dc schema:name pubmed_id
157 schema:value 19288266
158 rdf:type schema:PropertyValue
159 N755baae4053a4c72a2b02b8f950cdd4c rdf:first sg:person.01235544044.42
160 rdf:rest N0e0d2c44ad2844a7af244b3c8cbac1a2
161 N84342e60f63f4ea18f5257995f0302d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Caspase 3
163 rdf:type schema:DefinedTerm
164 N8e028bc7c9614ec7a74a6a102e896790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Ureteral Obstruction
166 rdf:type schema:DefinedTerm
167 N9d78d08ff5684bd4bf2a0731bbb91494 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mice, Inbred C57BL
169 rdf:type schema:DefinedTerm
170 N9ef47e05cc274f15aefa8ad89be66904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Actins
172 rdf:type schema:DefinedTerm
173 Nb15d160051e84b8d99e51c4214623064 rdf:first sg:person.01065110724.36
174 rdf:rest Nb9466fbf6ac943dcad7f20f9acbf4f76
175 Nb804718882684af6820312816a177b1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Proto-Oncogene Proteins p21(ras)
177 rdf:type schema:DefinedTerm
178 Nb9466fbf6ac943dcad7f20f9acbf4f76 rdf:first sg:person.014102272764.46
179 rdf:rest rdf:nil
180 Nc2c0fadee300434db19334ae96fab817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Ureter
182 rdf:type schema:DefinedTerm
183 Nc494f5ebc74c44ce914453901673ef3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Ligation
185 rdf:type schema:DefinedTerm
186 Nce5d2da509fe48398df04709c87e0595 schema:issueNumber 6
187 rdf:type schema:PublicationIssue
188 Ndd5f2150b5904453b6a2bfb96af9c7fb rdf:first sg:person.0743254021.19
189 rdf:rest N755baae4053a4c72a2b02b8f950cdd4c
190 Ne3f0753734f648d08f67ffe9b2e531b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Mice
192 rdf:type schema:DefinedTerm
193 Nf225695cc3c741b7adf93e6b5432a5b3 rdf:first sg:person.01111611561.11
194 rdf:rest Ndd5f2150b5904453b6a2bfb96af9c7fb
195 Nf8a3d8e168284976839ab17c010eeaa1 schema:name dimensions_id
196 schema:value pub.1030097244
197 rdf:type schema:PropertyValue
198 Nfd13e01452784aab8fc0bc78310ec17f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Kidney Diseases
200 rdf:type schema:DefinedTerm
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
205 schema:name Clinical Sciences
206 rdf:type schema:DefinedTerm
207 sg:journal.1094127 schema:issn 0724-4983
208 1433-8726
209 schema:name World Journal of Urology
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01065110724.36 schema:affiliation grid-institutes:grid.428472.f
213 schema:familyName Santos
214 schema:givenName Eugenio
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065110724.36
216 rdf:type schema:Person
217 sg:person.01111611561.11 schema:affiliation grid-institutes:grid.11762.33
218 schema:familyName Grande
219 schema:givenName María T.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111611561.11
221 rdf:type schema:Person
222 sg:person.01205721071.24 schema:affiliation grid-institutes:grid.411052.3
223 schema:familyName Cannata-Andía
224 schema:givenName Jorge B.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205721071.24
226 rdf:type schema:Person
227 sg:person.01235544044.42 schema:affiliation grid-institutes:grid.428472.f
228 schema:familyName Núñez
229 schema:givenName Alejandro
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235544044.42
231 rdf:type schema:Person
232 sg:person.014102272764.46 schema:affiliation grid-institutes:grid.11762.33
233 schema:familyName López-Novoa
234 schema:givenName José M.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014102272764.46
236 rdf:type schema:Person
237 sg:person.0743254021.19 schema:affiliation grid-institutes:grid.11762.33
238 schema:familyName Arévalo
239 schema:givenName Miguel
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743254021.19
241 rdf:type schema:Person
242 sg:pub.10.1023/b:appt.0000045801.15585.dd schema:sameAs https://app.dimensions.ai/details/publication/pub.1020224719
243 https://doi.org/10.1023/b:appt.0000045801.15585.dd
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.onc.1201284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047596897
246 https://doi.org/10.1038/sj.onc.1201284
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/sj.onc.1202251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051703411
249 https://doi.org/10.1038/sj.onc.1202251
250 rdf:type schema:CreativeWork
251 grid-institutes:grid.11762.33 schema:alternateName Departamento de Anatomía e Histología Humanas, Universidad de Salamanca, Salamanca, Spain
252 Departamento de Fisiología y Farmacología, Instituto “Reina Sofía” de Investigación Nefrológica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain
253 schema:name Departamento de Anatomía e Histología Humanas, Universidad de Salamanca, Salamanca, Spain
254 Departamento de Fisiología y Farmacología, Instituto “Reina Sofía” de Investigación Nefrológica, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain
255 rdf:type schema:Organization
256 grid-institutes:grid.411052.3 schema:alternateName Mineral, Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, Hospital Universitario Central de Asturias, Oviedo, Spain
257 schema:name Mineral, Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, Hospital Universitario Central de Asturias, Oviedo, Spain
258 rdf:type schema:Organization
259 grid-institutes:grid.428472.f schema:alternateName Centro de Investigación del Cáncer, CSIC-USAL, Salamanca, Spain
260 schema:name Centro de Investigación del Cáncer, CSIC-USAL, Salamanca, Spain
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...