Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03-15

AUTHORS

María T. Grande, Miguel Arévalo, Alejandro Núñez, Jorge B. Cannata-Andía, Eugenio Santos, José M. López-Novoa

ABSTRACT

PurposeTo assess the contribution of two different Ras monomeric GTPases isoforms H- and N-Ras in the early changes associated to obstructive nephropathy induced by unilateral ureteral obstruction (UUO).MethodsUUO was performed in N-ras (N-ras−/−) and H-ras (H-ras−/−) knock-out mice and control (H-ras+/+/N-ras+/+) mice of C57Bl/6 background. Fibronectin, α-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry. Ras isoforms activation and caspase activity were determined by both western blot and ELISA.ResultsThree days after UUO, obstructed (O) kidneys of H-ras−/−, N-ras−/− and H-ras+/+/N-ras+/+ mice showed no significant differences in activated total ras, pERK1/2, pAkt, total Akt levels, fibronectin, α-SMA expression, cell proliferation, and activated caspase-3. The morphological alterations in the O kidneys, revealed by histological and immunohistochemical studies, were also similar in H-ras−/−, N-ras−/−, and H-ras+/+/N-ras+/+ mice.ConclusionsThese data suggest that the activation of H-ras and N-ras isoforms does not play a major role in the early renal damage induced by UUO. More... »

PAGES

787

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00345-009-0399-8

DOI

http://dx.doi.org/10.1007/s00345-009-0399-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030097244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19288266


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