Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-03

AUTHORS

Luc Grobet, Dominique Poncelet, Luis José Royo, Benoit Brouwers, Dimitri Pirottin, Charles Michaux, François Ménissier, Marta Zanotti, Susana Dunner, Michel Georges

ABSTRACT

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-offunction mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling. More... »

PAGES

210-213

Journal

TITLE

Mammalian Genome

ISSUE

3

VOLUME

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s003359900727

DOI

http://dx.doi.org/10.1007/s003359900727

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047312014

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9501304


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