A long-range physical map of human Chromosome 21q22.1 band from the YAC continuum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-04

AUTHORS

T. Eki, M. Abe, K. Furuya, I. Ahmad, N. Fujishima, H. Kishida, A. Shiratori, T. Onozaki, K. Yokoyama, D. Le Paslier, D. Cohen, F. Hanaoka, Y. Murakami

ABSTRACT

The human Chromosome (Chr) 21q22.1 region contains several genes for cytokines and neurotransmitters and the gene for Superoxide dismutase (mutant forms of which can cause familial amyotrophic lateral sclerosis). A region of approximately 5.8 Mb encompassing D21S82 and the glycinamide ribonucleotide transformylase (GART) loci was covered by overlapping YAC clones, which were contiguously ordered by clone walking with sequence-tagged site (STSs). A total of 76 markers, including 29 YAC end-specific STSs, were unambiguously ordered in this 5.8-Mb region, and the average interval between markers was 76 kb. Restriction maps of the YAC clones with rare-cutting enzymes were simultaneously prepared, and the restriction sites were aligned to obtain a consensus restriction map of the proximal region of the 21q22.1 band. The restriction map made from 44 overlapping YACs contains 54 physically assigned STSs. By integrating the consensus map of the adjacent 1.8-Mb region, we obtained a fine physical map spanning 6.5 Mb of human Chr 21q22.1. This map contains 24 precisely positioned end-specific STSs and 12 Afofl-linking markers. More than 39 potential CpG islands were identified in this region and were found to be unevenly distributed. This physical map and the YACs should be useful as a reference map and as a resource for further structural analysis of the Giemsa-negative band (R-band) of Chr 21q22.1. More... »

PAGES

303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s003359900087

DOI

http://dx.doi.org/10.1007/s003359900087

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025197835

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8661703


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25 schema:description The human Chromosome (Chr) 21q22.1 region contains several genes for cytokines and neurotransmitters and the gene for Superoxide dismutase (mutant forms of which can cause familial amyotrophic lateral sclerosis). A region of approximately 5.8 Mb encompassing D21S82 and the glycinamide ribonucleotide transformylase (GART) loci was covered by overlapping YAC clones, which were contiguously ordered by clone walking with sequence-tagged site (STSs). A total of 76 markers, including 29 YAC end-specific STSs, were unambiguously ordered in this 5.8-Mb region, and the average interval between markers was 76 kb. Restriction maps of the YAC clones with rare-cutting enzymes were simultaneously prepared, and the restriction sites were aligned to obtain a consensus restriction map of the proximal region of the 21q22.1 band. The restriction map made from 44 overlapping YACs contains 54 physically assigned STSs. By integrating the consensus map of the adjacent 1.8-Mb region, we obtained a fine physical map spanning 6.5 Mb of human Chr 21q22.1. This map contains 24 precisely positioned end-specific STSs and 12 Afofl-linking markers. More than 39 potential CpG islands were identified in this region and were found to be unevenly distributed. This physical map and the YACs should be useful as a reference map and as a resource for further structural analysis of the Giemsa-negative band (R-band) of Chr 21q22.1.
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33 Chromosome (Chr) 21q22.1 region
34 Chromosome 21q22.1 band
35 CpG islands
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37 Further structural analysis
38 Giemsa-negative bands
39 MB
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44 YACs
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52 continuum
53 cytokines
54 dismutase
55 end-specific STSs
56 enzyme
57 fine physical map
58 genes
59 glycinamide ribonucleotide transformylase (GART) loci
60 human Chr 21q22.1
61 human Chromosome (Chr) 21q22.1 region
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63 intervals
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67 long-range physical map
68 maps
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70 neurotransmitters
71 overlapping YACs
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74 proximal region
75 rare-cutting enzymes
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78 resources
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81 ribonucleotide transformylase (GART) loci
82 sequence-tagged sites
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85 superoxide dismutase
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