Liver stiffness measurement by magnetic resonance elastography is not affected by hepatic steatosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-08-25

AUTHORS

Jie Chen, Alina M. Allen, Terry M. Therneau, Jun Chen, Jiahui Li, Safa Hoodeshenas, Jingbiao Chen, Xin Lu, Zheng Zhu, Sudhakar K. Venkatesh, Bin Song, Richard L. Ehman, Meng Yin

ABSTRACT

ObjectivesTo evaluate the relationship between biopsy-assessed hepatic steatosis, magnetic resonance imaging (MRI)–assessed proton density fat fraction (PDFF), and magnetic resonance elastography (MRE)–assessed liver stiffness measurement (LSM), in patients with or at risk for nonalcoholic fatty liver disease (NAFLD).MethodsA retrospective study was performed, encompassing 256 patients who had a liver biopsy and MRI/MRE examination performed within 1 year. Clinical and laboratory data were retrieved from the electronic medical record. Hepatic steatosis and fibrosis were assessed by histopathological grading/staging. First, we analyzed the diagnostic performance of PDFF for distinguishing hepatic steatosis with the receiver operating characteristic analyses. Second, variables influencing LSM were screened with univariant analyses, then identified with multivariable linear regression. Finally, the potential relationship between PDFF and LSM was assessed with linear regression after adjustment for other influencing factors, in patients with diagnosed steatosis (PDFF ≥ 5%).ResultsThe diagnostic accuracy of PDFF in distinguishing steatosis grades (S0-3) was above 0.82. No significant difference in LSM was found between patients with S1, S2, and S3 steatosis and between all steatosis grades after patients were grouped according to fibrosis stage. No statistically significant relationship was found between the LSM and PDFF (estimate = − 0.02, p = 0.065) after adjustment for fibrosis stage and age in patients with diagnosed steatosis (PDFF ≥ 5%).ConclusionsIn patients with NAFLD, the severity of hepatic steatosis has no significant influence on the liver stiffness measurement with magnetic resonance elastography.Key Points• The MRI-based proton density fat fraction provides a quantitative assessment of hepatic steatosis with high accuracy.• No significant effect of hepatic steatosis on MRE-based liver stiffness measurement was found in patients with S1, S2, and S3 steatosis and between all steatosis grades after patients were grouped according to fibrosis stage.• After adjusting for fibrosis stage and age, there was no statistically significant relationship between liver stiffness and proton density fat fraction in patients with hepatic steatosis (p = 0.065). More... »

PAGES

950-958

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-021-08225-w

DOI

http://dx.doi.org/10.1007/s00330-021-08225-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140637039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34432123


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85 significant influence
86 significant relationship
87 stage
88 staging
89 steatosis
90 steatosis grade
91 stiffness
92 stiffness measurement
93 study
94 univariant analysis
95 variables
96 years
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