Intravoxel incoherent motion (IVIM) 3 T MRI for orbital lesion characterization View Full Text


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Article Info

DATE

2020-08-01

AUTHORS

Augustin Lecler, Loïc Duron, Mathieu Zmuda, Kevin Zuber, Olivier Bergès, Marc Putterman, Julien Savatovsky, Laure Fournier

ABSTRACT

ObjectivesTo determine the diagnostic accuracy of MRI intravoxel incoherent motion (IVIM) when characterizing orbital lesions, which is challenging due to a wide range of locations and histologic types.MethodsThis IRB-approved prospective single-center study enrolled participants presenting with an orbital lesion undergoing a 3-T MRI prior to surgery from December 2015 to July 2019. An IVIM sequence with 15 b values ranging from 0 to 2000 s/mm2 was performed. Two neuroradiologists, blinded to clinical data, individually analyzed morphological MRIs. They drew one region of interest inside each orbital lesion, providing apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudodiffusion coefficient (D*) values. T test, Mann-Whitney U test, and receiver operating characteristic curve analyses were performed to discriminate between orbital lesions and to determine the diagnostic accuracy of the IVIM parameters.ResultsOne hundred fifty-six participants (84 women and 72 men, mean age 54.4 ± 17.5 years) with 167 orbital lesions (98/167 [59%] benign lesions including 54 orbital inflammations and 69/167 [41%] malignant lesions including 32 lymphomas) were included in the study.ADC and D were significantly lower in malignant than in benign lesions: 0.8 × 10−3 mm2/s [0.45] versus 1.04 × 10−3 mm2/s [0.33], p < 0.001, and 0.75 × 10−3 mm2/s [0.40] versus 0.98 × 10−3 mm2/s [0.42], p < 0.001, respectively. D* was significantly higher in malignant lesions than in benign ones: 12.8 × 10−3 mm2/s [20.17] versus 7.52 × 10−3 mm2/s [7.57], p = 0.005. Area under curve was of 0.73, 0.74, 0.72, and 0.81 for ADC, D, D*, and a combination of D, f, and D*, respectively.ConclusionsOur study showed that IVIM might help better characterize orbital lesions.Key Points• Intravoxel incoherent motion (IVIM) helps clinicians to assess patients with orbital lesions.• Intravoxel incoherent motion (IVIM) helps clinicians to characterize orbital lymphoma versus orbital inflammation.• Management of patients becomes more appropriate. More... »

PAGES

14-23

References to SciGraph publications

  • 2018-05-02. Differentiation of orbital lymphoma and idiopathic orbital inflammatory pseudotumor: combined diagnostic value of conventional MRI and histogram analysis of ADC maps in BMC MEDICAL IMAGING
  • 2017-07-04. Repeatability of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0 Tesla in orbital lesions in EUROPEAN RADIOLOGY
  • 2018-04-04. How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy? in EYE
  • 2016-06-07. Usefulness of colour Doppler flow imaging in the management of lacrimal gland lesions in EUROPEAN RADIOLOGY
  • 2019-02-14. Combining Multiple Magnetic Resonance Imaging Sequences Provides Independent Reproducible Radiomics Features in SCIENTIFIC REPORTS
  • 2019-06-18. Effect of combination and number of b values in IVIM analysis with post-processing methodology: simulation and clinical study in MAGNETIC RESONANCE MATERIALS IN PHYSICS, BIOLOGY AND MEDICINE
  • 2013-07-12. Orbital Masses: the Usefulness of Diffusion-Weighted Imaging in Lesion Categorization in CLINICAL NEURORADIOLOGY
  • 2017-08-04. Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques in EUROPEAN RADIOLOGY
  • 2010-02-04. Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults in EUROPEAN RADIOLOGY
  • 2019-05-27. MRI of Pediatric Orbital Masses: Role of Quantitative Diffusion-weighted Imaging in Differentiating Benign from Malignant Lesions in CLINICAL NEURORADIOLOGY
  • 2016-07-19. Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign in EUROPEAN RADIOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00330-020-07103-1

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        "description": "ObjectivesTo determine the diagnostic accuracy of MRI intravoxel incoherent motion (IVIM) when characterizing orbital lesions, which is challenging due to a wide range of locations and histologic types.MethodsThis IRB-approved prospective single-center study enrolled participants presenting with an orbital lesion undergoing a 3-T MRI prior to surgery from December 2015 to July 2019. An IVIM sequence with 15 b values ranging from 0 to 2000\u00a0s/mm2 was performed. Two neuroradiologists, blinded to clinical data, individually analyzed morphological MRIs. They drew one region of interest inside each orbital lesion, providing apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudodiffusion coefficient (D*) values. T test, Mann-Whitney U test, and receiver operating characteristic curve analyses were performed to discriminate between orbital lesions and to determine the diagnostic accuracy of the IVIM parameters.ResultsOne hundred fifty-six participants (84 women and 72 men, mean age 54.4\u2009\u00b1\u200917.5\u00a0years) with 167 orbital lesions (98/167 [59%] benign lesions including 54 orbital inflammations and 69/167 [41%] malignant lesions including 32 lymphomas) were included in the study.ADC and D were significantly lower in malignant than in benign lesions: 0.8\u2009\u00d7\u200910\u22123\u00a0mm2/s [0.45] versus 1.04\u2009\u00d7\u200910\u22123\u00a0mm2/s [0.33], p\u2009<\u20090.001, and 0.75\u2009\u00d7\u200910\u22123\u00a0mm2/s [0.40] versus 0.98\u2009\u00d7\u200910\u22123\u00a0mm2/s [0.42], p\u2009<\u20090.001, respectively. D* was significantly higher in malignant lesions than in benign ones: 12.8\u2009\u00d7\u200910\u22123\u00a0mm2/s [20.17] versus 7.52\u2009\u00d7\u200910\u22123\u00a0mm2/s [7.57], p\u2009=\u20090.005. Area under curve was of 0.73, 0.74, 0.72, and 0.81 for ADC, D, D*, and a combination of D, f, and D*, respectively.ConclusionsOur study showed that IVIM might help better characterize orbital lesions.Key Points\u2022 Intravoxel incoherent motion (IVIM) helps clinicians to assess patients with orbital lesions.\u2022 Intravoxel incoherent motion (IVIM) helps clinicians to characterize orbital lymphoma versus orbital inflammation.\u2022 Management of patients becomes more appropriate.", 
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    28 schema:description ObjectivesTo determine the diagnostic accuracy of MRI intravoxel incoherent motion (IVIM) when characterizing orbital lesions, which is challenging due to a wide range of locations and histologic types.MethodsThis IRB-approved prospective single-center study enrolled participants presenting with an orbital lesion undergoing a 3-T MRI prior to surgery from December 2015 to July 2019. An IVIM sequence with 15 b values ranging from 0 to 2000 s/mm2 was performed. Two neuroradiologists, blinded to clinical data, individually analyzed morphological MRIs. They drew one region of interest inside each orbital lesion, providing apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and pseudodiffusion coefficient (D*) values. T test, Mann-Whitney U test, and receiver operating characteristic curve analyses were performed to discriminate between orbital lesions and to determine the diagnostic accuracy of the IVIM parameters.ResultsOne hundred fifty-six participants (84 women and 72 men, mean age 54.4 ± 17.5 years) with 167 orbital lesions (98/167 [59%] benign lesions including 54 orbital inflammations and 69/167 [41%] malignant lesions including 32 lymphomas) were included in the study.ADC and D were significantly lower in malignant than in benign lesions: 0.8 × 10−3 mm2/s [0.45] versus 1.04 × 10−3 mm2/s [0.33], p < 0.001, and 0.75 × 10−3 mm2/s [0.40] versus 0.98 × 10−3 mm2/s [0.42], p < 0.001, respectively. D* was significantly higher in malignant lesions than in benign ones: 12.8 × 10−3 mm2/s [20.17] versus 7.52 × 10−3 mm2/s [7.57], p = 0.005. Area under curve was of 0.73, 0.74, 0.72, and 0.81 for ADC, D, D*, and a combination of D, f, and D*, respectively.ConclusionsOur study showed that IVIM might help better characterize orbital lesions.Key Points• Intravoxel incoherent motion (IVIM) helps clinicians to assess patients with orbital lesions.• Intravoxel incoherent motion (IVIM) helps clinicians to characterize orbital lymphoma versus orbital inflammation.• Management of patients becomes more appropriate.
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    43 ResultsOne hundred fifty
    44 T MRI
    45 U test
    46 accuracy
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    48 apparent diffusion coefficient
    49 area
    50 b-values
    51 benign lesions
    52 benign ones
    53 characteristic curve analysis
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    78 management
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    80 mm2
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    86 orbital inflammation
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    94 range
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