Ontology type: schema:ScholarlyArticle
2019-04-10
AUTHORSMarie-Pierre Vullierme, Lina Menassa, Anne Couvelard, Vinciane Rebours, Frédérique Maire, Tony Ibrahim, Jerome Cros, Philippe Ruszniewski, Alain Sauvanet, Philippe Levy, Philippe Soyer, Valerie Vilgrain
ABSTRACTPurposeTo evaluate whether pancreatic parenchymal abnormalities on magnetic resonance imaging (MRI) are associated with pancreatic intraepithelial neoplasia (PanIN) on histology.Materials and methodsRetrospective study approved by institutional review board. One hundred patients (48 men, 52 women; mean age, 53.2 ± 16.29 [SD]) underwent MRI before pancreatectomy for pancreatic tumors analyzed by two independent observers blinded to histopathological results for the presence of non-communicating microcysts and pancreatic atrophy (global or focal) beside tumors. MRI findings were compared to histopathological findings of resected specimens. Interobserver agreement was calculated. The association between parenchymal abnormalities and presence of PanIN was assessed by uni- and multivariate analyses.ResultsPanIN was present in 65/100 patients (65%). The presence of microcysts on MRI had a sensitivity of 52.3% (34/65 [95%CI, 51.92–52.70%]), a specificity of 77.1% (27/35 [95%CI, 76.70–77.59]), and accuracy of 61% (61/100 95%CI [50.7–70.6]) for the diagnosis of PanIN while global atrophy had a sensitivity of 24.6% (16/6 [95%CI, 24.28–24.95]) and a specificity of 97.1% (34/35 [95%CI, 96.97–97.32%]). In multivariate analysis, the presence of microcysts (OR, 3.37 [95%CI, 1.3–8.76]) (p = 0.0127) and global atrophy (OR, 9.79 [95%CI, 1.21–79.129]) (p = 0.0324) were identified as independent predictors of the presence of PanIN. The combination of these two findings was observed in 10/65 PanIN patients and not in patients without PanIN (p = 0.013 with an OR of infinity [95%CI, 1.3–infinity]) and was not discriminant for PanIN-3 and lower grade (p = 0.22). Interobserver agreement for the presence of microcysts was excellent (kappa = 0.92), and for the presence of global atrophy, it was good (kappa = 0.73).ConclusionThe presence of non-communicating microcysts on pre-operative MRI can be a significant predictor of PanIN in patients with pancreatic tumors.Key Points• In patients with pancreatic tumors who had partial pancreatectomy, MR non-communicating pancreatic microcysts have a 52.3% sensitivity, a 77.1% specificity, and a 61% accuracy for the presence of PanIN with univariate and with an odds ratio of 3.37 with multivariate analyses.• The association of global atrophy and non-communicating microcysts increases the predictive risk of PanIN. More... »
PAGES5731-5741
http://scigraph.springernature.com/pub.10.1007/s00330-019-06154-3
DOIhttp://dx.doi.org/10.1007/s00330-019-06154-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1113356254
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30972547
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Atrophy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma in Situ",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Pancreatic Ductal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Early Detection of Cancer",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Observer Variation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreas",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreatic Cyst",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreatic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Paris Diderot University, Sorbonne Paris Cit\u00e9, INSERM U1149 CRB3, Paris, France",
"id": "http://www.grid.ac/institutes/grid.508487.6",
"name": [
"Paris Diderot University, Sorbonne Paris Cit\u00e9, INSERM U1149 CRB3, Paris, France"
],
"type": "Organization"
},
"familyName": "Vullierme",
"givenName": "Marie-Pierre",
"id": "sg:person.01231224366.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231224366.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Imaging Department, Hotel-Dieu de France Hospital, Beirut, Lebanon",
"id": "http://www.grid.ac/institutes/grid.413559.f",
"name": [
"Imaging Department, Hotel-Dieu de France Hospital, Beirut, Lebanon"
],
"type": "Organization"
},
"familyName": "Menassa",
"givenName": "Lina",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pathology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Couvelard",
"givenName": "Anne",
"id": "sg:person.0751137045.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751137045.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pancreatology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pancreatology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Rebours",
"givenName": "Vinciane",
"id": "sg:person.01017252245.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017252245.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pancreatology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pancreatology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Maire",
"givenName": "Fr\u00e9d\u00e9rique",
"id": "sg:person.01351504544.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351504544.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Oncology Department, Clinical Research Units, Clinical Biostatistical Research Units, Saint Joseph University, Beirut, Lebanon",
"id": "http://www.grid.ac/institutes/grid.42271.32",
"name": [
"Oncology Department, Clinical Research Units, Clinical Biostatistical Research Units, Saint Joseph University, Beirut, Lebanon"
],
"type": "Organization"
},
"familyName": "Ibrahim",
"givenName": "Tony",
"id": "sg:person.014066472171.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014066472171.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pathology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Cros",
"givenName": "Jerome",
"id": "sg:person.01362452660.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362452660.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pancreatology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pancreatology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Ruszniewski",
"givenName": "Philippe",
"id": "sg:person.0640551545.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640551545.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepato Pancreato Biliary Surgery, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Hepato Pancreato Biliary Surgery, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Sauvanet",
"givenName": "Alain",
"id": "sg:person.01201614045.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201614045.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pancreatology, Beaujon University Hospital, Clichy, France",
"id": "http://www.grid.ac/institutes/grid.411599.1",
"name": [
"Department of Pancreatology, Beaujon University Hospital, Clichy, France"
],
"type": "Organization"
},
"familyName": "Levy",
"givenName": "Philippe",
"id": "sg:person.0740232450.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740232450.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Cochin University Hospital, Paris, France",
"id": "http://www.grid.ac/institutes/grid.411784.f",
"name": [
"Department of Radiology, Cochin University Hospital, Paris, France"
],
"type": "Organization"
},
"familyName": "Soyer",
"givenName": "Philippe",
"id": "sg:person.0764247237.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764247237.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Paris Diderot University, Sorbonne Paris Cit\u00e9, INSERM U1149 CRB3, Paris, France",
"id": "http://www.grid.ac/institutes/grid.508487.6",
"name": [
"Paris Diderot University, Sorbonne Paris Cit\u00e9, INSERM U1149 CRB3, Paris, France"
],
"type": "Organization"
},
"familyName": "Vilgrain",
"givenName": "Valerie",
"id": "sg:person.0761705775.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761705775.52"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00428-005-0032-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050882089",
"https://doi.org/10.1007/s00428-005-0032-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11605-007-0367-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019461420",
"https://doi.org/10.1007/s11605-007-0367-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00330-009-1391-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006944099",
"https://doi.org/10.1007/s00330-009-1391-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature19823",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009540373",
"https://doi.org/10.1038/nature19823"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10689-012-9582-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034221414",
"https://doi.org/10.1007/s10689-012-9582-y"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04-10",
"datePublishedReg": "2019-04-10",
"description": "PurposeTo evaluate whether pancreatic parenchymal abnormalities on magnetic resonance imaging (MRI) are associated with pancreatic intraepithelial neoplasia (PanIN) on histology.Materials and methodsRetrospective study approved by institutional review board. One hundred patients (48 men, 52 women; mean age, 53.2\u2009\u00b1\u200916.29 [SD]) underwent MRI before pancreatectomy for pancreatic tumors analyzed by two independent observers blinded to histopathological results for the presence of non-communicating microcysts and pancreatic atrophy (global or focal) beside tumors. MRI findings were compared to histopathological findings of resected specimens. Interobserver agreement was calculated. The association between parenchymal abnormalities and presence of PanIN was assessed by uni- and multivariate analyses.ResultsPanIN was present in 65/100 patients (65%). The presence of microcysts on MRI had a sensitivity of 52.3% (34/65 [95%CI, 51.92\u201352.70%]), a specificity of 77.1% (27/35 [95%CI, 76.70\u201377.59]), and accuracy of 61% (61/100 95%CI [50.7\u201370.6]) for the diagnosis of PanIN while global atrophy had a sensitivity of 24.6% (16/6 [95%CI, 24.28\u201324.95]) and a specificity of 97.1% (34/35 [95%CI, 96.97\u201397.32%]). In multivariate analysis, the presence of microcysts (OR, 3.37 [95%CI, 1.3\u20138.76]) (p\u2009=\u20090.0127) and global atrophy (OR, 9.79 [95%CI, 1.21\u201379.129]) (p\u2009=\u20090.0324) were identified as independent predictors of the presence of PanIN. The combination of these two findings was observed in 10/65 PanIN patients and not in patients without PanIN (p\u2009=\u20090.013 with an OR of infinity [95%CI, 1.3\u2013infinity]) and was not discriminant for PanIN-3 and lower grade (p\u2009=\u20090.22). Interobserver agreement for the presence of microcysts was excellent (kappa\u2009=\u20090.92), and for the presence of global atrophy, it was good (kappa\u2009=\u20090.73).ConclusionThe presence of non-communicating microcysts on pre-operative MRI can be a significant predictor of PanIN in patients with pancreatic tumors.Key Points\u2022 In patients with pancreatic tumors who had partial pancreatectomy, MR non-communicating pancreatic microcysts have a 52.3% sensitivity, a 77.1% specificity, and a 61% accuracy for the presence of PanIN with univariate and with an odds ratio of 3.37 with multivariate analyses.\u2022 The association of global atrophy and non-communicating microcysts increases the predictive risk of PanIN.",
"genre": "article",
"id": "sg:pub.10.1007/s00330-019-06154-3",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1289120",
"issn": [
"0938-7994",
"1432-1084"
],
"name": "European Radiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "29"
}
],
"keywords": [
"presence of PanIN",
"presence of microcysts",
"magnetic resonance imaging",
"pancreatic intraepithelial neoplasia",
"pancreatic tumors",
"global atrophy",
"parenchymal abnormalities",
"intraepithelial neoplasia",
"multivariate analysis",
"pre-operative magnetic resonance imaging",
"interobserver agreement",
"pancreatic parenchymal abnormalities",
"institutional review board",
"MethodsRetrospective study",
"MRI findings",
"histopathological findings",
"independent predictors",
"pancreatic atrophy",
"histopathological results",
"odds ratio",
"PanIN-3",
"partial pancreatectomy",
"patients",
"atrophy",
"ConclusionThe presence",
"resonance imaging",
"pancreatectomy",
"tumors",
"review board",
"PanIN",
"MR imaging",
"microcysts",
"predictive risk",
"independent observers",
"significant predictors",
"neoplasia",
"low grade",
"abnormalities",
"predictors",
"association",
"preliminary study",
"findings",
"specificity",
"imaging",
"PurposeTo",
"histology",
"pancreas",
"diagnosis",
"univariate",
"sensitivity",
"presence",
"risk",
"study",
"grade",
"analysis",
"specimens",
"combination",
"ratio",
"results",
"observer",
"accuracy",
"board",
"materials",
"agreement"
],
"name": "Non-branched microcysts of the pancreas on MR imaging of patients with pancreatic tumors who had pancreatectomy may predict the presence of pancreatic intraepithelial neoplasia (PanIN): a preliminary study",
"pagination": "5731-5741",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113356254"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00330-019-06154-3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30972547"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00330-019-06154-3",
"https://app.dimensions.ai/details/publication/pub.1113356254"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:35",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_830.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00330-019-06154-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00330-019-06154-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00330-019-06154-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00330-019-06154-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00330-019-06154-3'
This table displays all metadata directly associated to this object as RDF triples.
310 TRIPLES
22 PREDICATES
113 URIs
100 LITERALS
25 BLANK NODES