Ontology type: schema:ScholarlyArticle
2019-01-14
AUTHORSDong Ho Lee, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Jung-Hwan Yoon, Yoon Jun Kim, Jeong-Hoon Lee, Su Jong Yu, Joon Koo Han
ABSTRACTOBJECTIVE: This study was conducted in order to evaluate whether the presence of nonhypervascular hepatobiliary phase (HBP) hypointense nodules can help determine the treatment method for single nodular hepatocellular carcinoma (HCC) ≤ 3 cm. METHODS: This study was approved by the institutional review board. A total of 345 patients with single nodular HCC ≤ 3 cm underwent pretreatment gadoxetic acid-enhanced MR followed by hepatic resection (n = 123) or radiofrequency ablation (RFA) (n = 222). We retrospectively analyzed the results of tumor recurrence according to the presence of nonhypervascular HBP hypointense nodules at each treatment method. RESULTS: Nonhypervascular HBP hypointense nodules were found in 18 of 123 patients treated by hepatic resection and in 63 of 222 patients who underwent RFA. The presence of nonhypervascular HBP hypointense nodules was a significant affecting factor for recurrence-free survival (RFS) after both hepatic resection (p = 0.004, hazard ratio [HR] = 2.75 [1.38-5.51]) and RFA (p = 0.004, HR = 1.78 [1.20-2.63]). In patients with nonhypervascular HBP hypointense nodules, 5-year RFS was 34.0% after hepatic resection, which was not significantly different from the 28.0% after RFA (p = 0.618). However, in patients without nonhypervascular HBP hypointense nodules, 5-year RFS was 65.0% after hepatic resection, which was significantly better than the 51.0% after RFA (p = 0.042), owing to significantly lower cumulative incidence of local tumor progression after hepatic resection (p < 0.001). CONCLUSIONS: While the presence of nonhypervascular HBP hypointense nodules on gadoxetic acid-enhanced MR taken prior to treatment was a significant predictive factor of tumor recurrence after both hepatic resection and RFA, in patients without nonhypervascular HBP hypointense nodules, hepatic resection can provide significantly better RFS than RFA. KEY POINTS: • The presence of nonhypervascular hepatobiliary phase (HBP) hypointense nodules was a significant risk factor for tumor recurrence after either hepatectomy or radiofrequency ablation (RFA). • Hepatectomy provided significantly better recurrence-free survival than RFA in patients without nonhypervascular HBP hypointense nodules. • In patients with nonhypervascular HBP hypointense nodules, recurrence-free survival after RFA was comparable to hepatectomy. More... »
PAGES1-10
http://scigraph.springernature.com/pub.10.1007/s00330-018-5941-x
DOIhttp://dx.doi.org/10.1007/s00330-018-5941-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111409864
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30643939
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, 03080, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Dong Ho",
"id": "sg:person.0662301041.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662301041.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, 03080, Seoul, South Korea",
"Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jeong Min",
"id": "sg:person.01266602714.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266602714.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Konkuk University",
"id": "https://www.grid.ac/institutes/grid.258676.8",
"name": [
"Department of Radiology, Konkuk University School of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Mi Hye",
"id": "sg:person.0647654606.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647654606.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Radiology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Hur",
"givenName": "Bo Yun",
"id": "sg:person.01074174141.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074174141.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Surgery, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Yi",
"givenName": "Nam-Joon",
"id": "sg:person.0654144447.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654144447.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Surgery, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Kwang-Woong",
"id": "sg:person.01210315044.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210315044.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Surgery, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Suh",
"givenName": "Kyung-Suk",
"id": "sg:person.01166661455.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166661455.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Yoon",
"givenName": "Jung-Hwan",
"id": "sg:person.0666661531.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666661531.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Yoon Jun",
"id": "sg:person.0716302167.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716302167.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jeong-Hoon",
"id": "sg:person.016451652620.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451652620.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412484.f",
"name": [
"Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Su Jong",
"id": "sg:person.01141310262.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141310262.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, 03080, Seoul, South Korea",
"Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Han",
"givenName": "Joon Koo",
"id": "sg:person.0647723014.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647723014.95"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.3348/kjr.2013.14.6.894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013265305"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(11)61347-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017225557"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.12112649",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032264687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.24199",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032908435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2016.09.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037167057"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.12112677",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037966788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/lt.21330",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039004277"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.23181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042426035"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.2008.536",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042825543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.1440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043886019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000201480.65519.b8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045495945"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000201480.65519.b8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045495945"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000201480.65519.b8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045495945"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2353042205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046562244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2353042205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046562244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2353042205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046562244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2353042205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046562244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2353042205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046562244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2014.12.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048965616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jamcollsurg.2010.03.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049711317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2013.01.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050347267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.13130940",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050612935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2011.12.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051138497"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2214/ajr.10.5390",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069301221"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2214/ajr.12.9136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069302756"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3350/cmh.2016.0026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071155283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3350/cmh.2016.22.1.7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071155320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.29086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074239526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.14140690",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079024270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3348/kjr.2017.18.3.427",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084775246"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2214/ajr.16.17711",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090901175"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2017162452",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092115861"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2018.03.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103170407"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-01-14",
"datePublishedReg": "2019-01-14",
"description": "OBJECTIVE: This study was conducted in order to evaluate whether the presence of nonhypervascular hepatobiliary phase (HBP) hypointense nodules can help determine the treatment method for single nodular hepatocellular carcinoma (HCC) \u2264\u20093\u00a0cm.\nMETHODS: This study was approved by the institutional review board. A total of 345 patients with single nodular HCC \u2264\u20093\u00a0cm underwent pretreatment gadoxetic acid-enhanced MR followed by hepatic resection (n\u2009=\u2009123) or radiofrequency ablation (RFA) (n\u2009=\u2009222). We retrospectively analyzed the results of tumor recurrence according to the presence of nonhypervascular HBP hypointense nodules at each treatment method.\nRESULTS: Nonhypervascular HBP hypointense nodules were found in 18 of 123 patients treated by hepatic resection and in 63 of 222 patients who underwent RFA. The presence of nonhypervascular HBP hypointense nodules was a significant affecting factor for recurrence-free survival (RFS) after both hepatic resection (p\u2009=\u20090.004, hazard ratio [HR]\u2009=\u20092.75 [1.38-5.51]) and RFA (p\u2009=\u20090.004, HR\u2009=\u20091.78 [1.20-2.63]). In patients with nonhypervascular HBP hypointense nodules, 5-year RFS was 34.0% after hepatic resection, which was not significantly different from the 28.0% after RFA (p\u2009=\u20090.618). However, in patients without nonhypervascular HBP hypointense nodules, 5-year RFS was 65.0% after hepatic resection, which was significantly better than the 51.0% after RFA (p\u2009=\u20090.042), owing to significantly lower cumulative incidence of local tumor progression after hepatic resection (p\u2009<\u20090.001).\nCONCLUSIONS: While the presence of nonhypervascular HBP hypointense nodules on gadoxetic acid-enhanced MR taken prior to treatment was a significant predictive factor of tumor recurrence after both hepatic resection and RFA, in patients without nonhypervascular HBP hypointense nodules, hepatic resection can provide significantly better RFS than RFA.\nKEY POINTS: \u2022 The presence of nonhypervascular hepatobiliary phase (HBP) hypointense nodules was a significant risk factor for tumor recurrence after either hepatectomy or radiofrequency ablation (RFA). \u2022 Hepatectomy provided significantly better recurrence-free survival than RFA in patients without nonhypervascular HBP hypointense nodules. \u2022 In patients with nonhypervascular HBP hypointense nodules, recurrence-free survival after RFA was comparable to hepatectomy.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00330-018-5941-x",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1289120",
"issn": [
"0938-7994",
"1432-1084"
],
"name": "European Radiology",
"type": "Periodical"
}
],
"name": "Non-hypervascular hepatobiliary phase hypointense nodules on gadoxetic acid-enhanced MR can help determine the treatment method for HCC",
"pagination": "1-10",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b8fa65ef75aef968e1c0576ed92876f42c1a680cf920c3f73e9c2633f8799f57"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30643939"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9114774"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00330-018-5941-x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111409864"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00330-018-5941-x",
"https://app.dimensions.ai/details/publication/pub.1111409864"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T08:40",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000319_0000000319/records_11231_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00330-018-5941-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5941-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5941-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5941-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5941-x'
This table displays all metadata directly associated to this object as RDF triples.
231 TRIPLES
21 PREDICATES
53 URIs
18 LITERALS
7 BLANK NODES