Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Jonathan C. L. Rodrigues, Tamas Erdei, Amardeep Ghosh Dastidar, Gergley Szantho, Amy E. Burchell, Laura E. K. Ratcliffe, Emma C. Hart, Angus K. Nightingale, Julian F. R. Paton, Nathan E. Manghat, Mark C. K. Hamilton

ABSTRACT

OBJECTIVES: Left atrial enlargement (LAE) predicts cardiovascular morbidity and mortality. Impaired LA function also confers poor prognosis. This study aimed to determine whether left ventricular (LV) interstitial fibrosis is associated with LAE and LA impairment in systemic hypertension. METHODS: Following informed written consent, a prospective observational study of 86 hypertensive patients (49 ± 15 years, 53% male, office SBP 168 ± 30 mmHg, office DBP 97 ± 4 mmHg) and 20 normotensive controls (48 ± 13 years, 55% male, office SBP 130 ± 13 mmHg, office DBP 80 ± 11 mmHg) at 1.5-T cardiovascular magnetic resonance was conducted. Extracellular volume fraction (ECV) was calculated by T1-mapping. LA volume (LAV) was measured with biplane area-length method. LA reservoir, conduit and pump function were calculated with the phasic volumetric method. RESULTS: Indexed LAV correlated with indexed LV mass (R = 0.376, p < 0.0001) and ECV (R = 0.359, p = 0.001). However, ECV was the strongest significant predictor of LAE in multivariate regression analysis (odds ratio [95th confidence interval] 1.24 [1.04-1.48], p = 0.017). Indexed myocardial interstitial volume was associated with significant reductions in LA reservoir (R = -0.437, p < 0.0001) and conduit (R = -0.316, p = 0.003) but not pump (R = -0.167, p = 0.125) function. Multiple linear regression, correcting for age, gender, BMI, BP and diabetes, showed an independent decrease of 3.5% LA total emptying fraction for each 10 ml/m2 increase in myocardial interstitial volume (standard β coefficient -3.54, p = 0.002). CONCLUSIONS: LV extracellular expansion is associated with LAE and impaired LA reservoir and conduit function. Future studies should identify if targeting diffuse LV fibrosis is beneficial in reverse remodelling of LA structural and functional pathological abnormalities in hypertension. KEY POINTS: • Left atrial enlargement (LAE) and impairment are markers of adverse prognosis in systemic hypertension but their pathophysiology is poorly understood. • Left ventricular extracellular volume fraction was the strongest independent multivariate predictor of LAE and was associated with impaired left atrial reservoir and conduit function. • LV interstitial expansion may play a central role in the pathophysiology of adverse atrioventricular interaction in systemic hypertension. More... »

PAGES

1574-1585

References to SciGraph publications

  • 2009-08. Direct action of an angiotensin II receptor blocker on angiotensin II-induced left atrial conduction delay in spontaneously hypertensive rats in HYPERTENSION RESEARCH
  • 2015-12. Extracellular volume quantification in isolated hypertension - changes at the detectable limits? in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2009-06. The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients in HYPERTENSION RESEARCH
  • 2017-12. Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2017-12. IL-11 is a crucial determinant of cardiovascular fibrosis in NATURE
  • 2014-12. Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2011-12. Comparison of long and short axis quantification of left ventricular volume parameters by cardiovascular magnetic resonance, with ex-vivo validation in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2013-12. Relationship of phasic left atrial volume and emptying function to left ventricular filling pressure: a cardiovascular magnetic resonance study in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2011-12. Strong cardiovascular prognostic implication of quantitative left atrial contractile function assessed by cardiac magnetic resonance imaging in patients with chronic hypertension in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00330-018-5700-z

    DOI

    http://dx.doi.org/10.1007/s00330-018-5700-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107105596

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30232515


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiac Volume", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibrosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Atria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Ventricles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypertension", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Magnetic Resonance Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK", 
                "School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Science, University of Bristol, Bristol, UK", 
                "Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, BA1 3NG, Bath, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodrigues", 
            "givenName": "Jonathan C. L.", 
            "id": "sg:person.012520313742.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012520313742.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.410421.2", 
              "name": [
                "Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Erdei", 
            "givenName": "Tamas", 
            "id": "sg:person.014053753361.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014053753361.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.410421.2", 
              "name": [
                "Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dastidar", 
            "givenName": "Amardeep Ghosh", 
            "id": "sg:person.01305761173.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305761173.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.410421.2", 
              "name": [
                "Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szantho", 
            "givenName": "Gergley", 
            "id": "sg:person.07476175635.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476175635.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burchell", 
            "givenName": "Amy E.", 
            "id": "sg:person.01233430032.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233430032.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ratcliffe", 
            "givenName": "Laura E. K.", 
            "id": "sg:person.01301543232.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301543232.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Science, University of Bristol, Bristol, UK", 
                "BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hart", 
            "givenName": "Emma C.", 
            "id": "sg:person.0707305350.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707305350.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nightingale", 
            "givenName": "Angus K.", 
            "id": "sg:person.01231743740.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231743740.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Science, University of Bristol, Bristol, UK", 
                "BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paton", 
            "givenName": "Julian F. R.", 
            "id": "sg:person.010036473437.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010036473437.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bristol Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.418482.3", 
              "name": [
                "Department of Radiology, Bristol Royal Infirmary, University Bristol NHS Foundation Trust, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manghat", 
            "givenName": "Nathan E.", 
            "id": "sg:person.013052324361.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052324361.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bristol Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.418482.3", 
              "name": [
                "Department of Radiology, Bristol Royal Infirmary, University Bristol NHS Foundation Trust, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamilton", 
            "givenName": "Mark C. K.", 
            "id": "sg:person.016327572612.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327572612.22"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.jcmg.2015.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003175307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ehjci/jeu082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007406037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0162599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010683768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehs188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013620339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2009.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013968345", 
              "https://doi.org/10.1038/hr.2009.41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2009.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013968345", 
              "https://doi.org/10.1038/hr.2009.41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1532-429x-15-99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016037889", 
              "https://doi.org/10.1186/1532-429x-15-99"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(88)90416-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020775185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1532-429x-13-42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021051110", 
              "https://doi.org/10.1186/1532-429x-13-42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(03)00943-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022554711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(03)00943-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022554711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12968-015-0176-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022709866", 
              "https://doi.org/10.1186/s12968-015-0176-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.115.003285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023672591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.115.003285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023672591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.115.003285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023672591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ahj.2008.07.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024088590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/clc.4960200609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024910072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/heartjnl-2016-309576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025637589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2009.89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025965733", 
              "https://doi.org/10.1038/hr.2009.89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2009.89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025965733", 
              "https://doi.org/10.1038/hr.2009.89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/eht151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026649630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/jaha.114.000790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027859693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehm037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028551384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ehjci/jew117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031180051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardfail.2016.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032322392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/heartjnl-2011-301388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033968271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10641963.2014.933962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035901633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9149(98)00452-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036433658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurjhf/hft087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039244429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ehjci/jes102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044619179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1532-429x-13-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048829431", 
              "https://doi.org/10.1186/1532-429x-13-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.media.2007.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050536037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ejechocard/jeq175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051391099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12968-014-0099-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052425641", 
              "https://doi.org/10.1186/s12968-014-0099-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12968-014-0099-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052425641", 
              "https://doi.org/10.1186/s12968-014-0099-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2014.09.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053308148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10976640600572889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058381128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/jcmr-120016383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058431659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/jcmr-200036170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058431783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajh/hpt001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059382075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/tmi.2007.903693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061695088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.115.004299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063343315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circimaging.115.004299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063343315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1148/radiology.191.1.8134560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082666924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083085729", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12968-017-0327-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083735060", 
              "https://doi.org/10.1186/s12968-017-0327-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12968-017-0327-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083735060", 
              "https://doi.org/10.1186/s12968-017-0327-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092657209", 
              "https://doi.org/10.1038/nature24676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092657209", 
              "https://doi.org/10.1038/nature24676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2017.12.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101112169"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "OBJECTIVES: Left atrial enlargement (LAE) predicts cardiovascular morbidity and mortality. Impaired LA function also confers poor prognosis. This study aimed to determine whether left ventricular (LV) interstitial fibrosis is associated with LAE and LA impairment in systemic hypertension.\nMETHODS: Following informed written consent, a prospective observational study of 86 hypertensive patients (49 \u00b1 15 years, 53% male, office SBP 168 \u00b1 30 mmHg, office DBP 97 \u00b1 4 mmHg) and 20 normotensive controls (48 \u00b1 13 years, 55% male, office SBP 130 \u00b1 13 mmHg, office DBP 80 \u00b1 11 mmHg) at 1.5-T cardiovascular magnetic resonance was conducted. Extracellular volume fraction (ECV) was calculated by T1-mapping. LA volume (LAV) was measured with biplane area-length method. LA reservoir, conduit and pump function were calculated with the phasic volumetric method.\nRESULTS: Indexed LAV correlated with indexed LV mass (R = 0.376, p < 0.0001) and ECV (R = 0.359, p = 0.001). However, ECV was the strongest significant predictor of LAE in multivariate regression analysis (odds ratio [95th confidence interval] 1.24 [1.04-1.48], p = 0.017). Indexed myocardial interstitial volume was associated with significant reductions in LA reservoir (R = -0.437, p < 0.0001) and conduit (R = -0.316, p = 0.003) but not pump (R = -0.167, p = 0.125) function. Multiple linear regression, correcting for age, gender, BMI, BP and diabetes, showed an independent decrease of 3.5% LA total emptying fraction for each 10 ml/m2 increase in myocardial interstitial volume (standard \u03b2 coefficient -3.54, p = 0.002).\nCONCLUSIONS: LV extracellular expansion is associated with LAE and impaired LA reservoir and conduit function. Future studies should identify if targeting diffuse LV fibrosis is beneficial in reverse remodelling of LA structural and functional pathological abnormalities in hypertension.\nKEY POINTS: \u2022 Left atrial enlargement (LAE) and impairment are markers of adverse prognosis in systemic hypertension but their pathophysiology is poorly understood. \u2022 Left ventricular extracellular volume fraction was the strongest independent multivariate predictor of LAE and was associated with impaired left atrial reservoir and conduit function. \u2022 LV interstitial expansion may play a central role in the pathophysiology of adverse atrioventricular interaction in systemic hypertension.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00330-018-5700-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5142629", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5143234", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1289120", 
            "issn": [
              "0938-7994", 
              "1432-1084"
            ], 
            "name": "European Radiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "29"
          }
        ], 
        "name": "Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension", 
        "pagination": "1574-1585", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "123c6f3da4cdf0adef7f17ebb1d5b917011d2326452750063d4936701208af08"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30232515"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9114774"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00330-018-5700-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107105596"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00330-018-5700-z", 
          "https://app.dimensions.ai/details/publication/pub.1107105596"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78964_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00330-018-5700-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5700-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5700-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5700-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00330-018-5700-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    335 TRIPLES      21 PREDICATES      83 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00330-018-5700-z schema:about N0348c572c0214aa49aca44e404eba6aa
    2 N04483f80b6e1452ead1ee51af07b5e88
    3 N0b16522b54ea469ca59defc873f05afe
    4 N0e8f2fbd34fc43f9860b0ca5511f21b2
    5 N2ba1428aa018489493f72e136a6391bf
    6 N5e31af57cb0844df8800fb7a9cd81e94
    7 N82ee39ddbcad474bb99950780e9f2d7e
    8 N87fdb36ce8184874b491f272b96138dd
    9 N883fa2a042c14ecaa17da146abd0d986
    10 N8b78e3b123904367a060149e09629acb
    11 N8b84e941b14f4ac382b96658a64d2423
    12 Nc17c43b399d242e582e801264acff457
    13 Nc2fb9bd0eeea429b89ee79d872fa55dd
    14 anzsrc-for:11
    15 anzsrc-for:1102
    16 schema:author N1f48c2360bce4c00a346a94e6bd88a15
    17 schema:citation sg:pub.10.1038/hr.2009.41
    18 sg:pub.10.1038/hr.2009.89
    19 sg:pub.10.1038/nature24676
    20 sg:pub.10.1186/1532-429x-13-40
    21 sg:pub.10.1186/1532-429x-13-42
    22 sg:pub.10.1186/1532-429x-15-99
    23 sg:pub.10.1186/s12968-014-0099-4
    24 sg:pub.10.1186/s12968-015-0176-3
    25 sg:pub.10.1186/s12968-017-0327-9
    26 https://app.dimensions.ai/details/publication/pub.1083085729
    27 https://doi.org/10.1002/clc.4960200609
    28 https://doi.org/10.1016/0735-1097(88)90416-0
    29 https://doi.org/10.1016/j.ahj.2008.07.021
    30 https://doi.org/10.1016/j.cardfail.2016.01.009
    31 https://doi.org/10.1016/j.jacc.2017.12.035
    32 https://doi.org/10.1016/j.jcmg.2014.09.020
    33 https://doi.org/10.1016/j.jcmg.2015.08.007
    34 https://doi.org/10.1016/j.media.2007.10.009
    35 https://doi.org/10.1016/s0002-9149(98)00452-4
    36 https://doi.org/10.1016/s0735-1097(03)00943-4
    37 https://doi.org/10.1080/10976640600572889
    38 https://doi.org/10.1081/jcmr-120016383
    39 https://doi.org/10.1081/jcmr-200036170
    40 https://doi.org/10.1093/ajh/hpt001
    41 https://doi.org/10.1093/ehjci/jes102
    42 https://doi.org/10.1093/ehjci/jeu082
    43 https://doi.org/10.1093/ehjci/jew117
    44 https://doi.org/10.1093/ejechocard/jeq175
    45 https://doi.org/10.1093/eurheartj/ehm037
    46 https://doi.org/10.1093/eurheartj/ehs188
    47 https://doi.org/10.1093/eurheartj/eht151
    48 https://doi.org/10.1093/eurjhf/hft087
    49 https://doi.org/10.1109/tmi.2007.903693
    50 https://doi.org/10.1136/heartjnl-2011-301388
    51 https://doi.org/10.1136/heartjnl-2016-309576
    52 https://doi.org/10.1148/radiology.191.1.8134560
    53 https://doi.org/10.1161/circimaging.115.003285
    54 https://doi.org/10.1161/circimaging.115.004299
    55 https://doi.org/10.1161/jaha.114.000790
    56 https://doi.org/10.1371/journal.pone.0162599
    57 https://doi.org/10.3109/10641963.2014.933962
    58 schema:datePublished 2019-03
    59 schema:datePublishedReg 2019-03-01
    60 schema:description OBJECTIVES: Left atrial enlargement (LAE) predicts cardiovascular morbidity and mortality. Impaired LA function also confers poor prognosis. This study aimed to determine whether left ventricular (LV) interstitial fibrosis is associated with LAE and LA impairment in systemic hypertension. METHODS: Following informed written consent, a prospective observational study of 86 hypertensive patients (49 ± 15 years, 53% male, office SBP 168 ± 30 mmHg, office DBP 97 ± 4 mmHg) and 20 normotensive controls (48 ± 13 years, 55% male, office SBP 130 ± 13 mmHg, office DBP 80 ± 11 mmHg) at 1.5-T cardiovascular magnetic resonance was conducted. Extracellular volume fraction (ECV) was calculated by T1-mapping. LA volume (LAV) was measured with biplane area-length method. LA reservoir, conduit and pump function were calculated with the phasic volumetric method. RESULTS: Indexed LAV correlated with indexed LV mass (R = 0.376, p < 0.0001) and ECV (R = 0.359, p = 0.001). However, ECV was the strongest significant predictor of LAE in multivariate regression analysis (odds ratio [95th confidence interval] 1.24 [1.04-1.48], p = 0.017). Indexed myocardial interstitial volume was associated with significant reductions in LA reservoir (R = -0.437, p < 0.0001) and conduit (R = -0.316, p = 0.003) but not pump (R = -0.167, p = 0.125) function. Multiple linear regression, correcting for age, gender, BMI, BP and diabetes, showed an independent decrease of 3.5% LA total emptying fraction for each 10 ml/m2 increase in myocardial interstitial volume (standard β coefficient -3.54, p = 0.002). CONCLUSIONS: LV extracellular expansion is associated with LAE and impaired LA reservoir and conduit function. Future studies should identify if targeting diffuse LV fibrosis is beneficial in reverse remodelling of LA structural and functional pathological abnormalities in hypertension. KEY POINTS: • Left atrial enlargement (LAE) and impairment are markers of adverse prognosis in systemic hypertension but their pathophysiology is poorly understood. • Left ventricular extracellular volume fraction was the strongest independent multivariate predictor of LAE and was associated with impaired left atrial reservoir and conduit function. • LV interstitial expansion may play a central role in the pathophysiology of adverse atrioventricular interaction in systemic hypertension.
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree false
    64 schema:isPartOf N3ef916cbbf3b4a1caaf6a1ae80ec74cd
    65 N64fc2156b5a44ab9ac1d0292682012ad
    66 sg:journal.1289120
    67 schema:name Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension
    68 schema:pagination 1574-1585
    69 schema:productId N013eb423363541118c9ed97660047824
    70 Nd7eae1314e5d41dc98715802c02fefd6
    71 Nd7f870971b544137bfa7a705ddb6894f
    72 Ne2253f9d685142189e24a1086070a656
    73 Ne6432d8de3724e78b6cd27762c9024ef
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107105596
    75 https://doi.org/10.1007/s00330-018-5700-z
    76 schema:sdDatePublished 2019-04-11T13:20
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher N307301b2eac8422bb0ffa8d73da37243
    79 schema:url https://link.springer.com/10.1007%2Fs00330-018-5700-z
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N013eb423363541118c9ed97660047824 schema:name pubmed_id
    84 schema:value 30232515
    85 rdf:type schema:PropertyValue
    86 N0348c572c0214aa49aca44e404eba6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Humans
    88 rdf:type schema:DefinedTerm
    89 N04483f80b6e1452ead1ee51af07b5e88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Cardiac Volume
    91 rdf:type schema:DefinedTerm
    92 N0b16522b54ea469ca59defc873f05afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Prospective Studies
    94 rdf:type schema:DefinedTerm
    95 N0e8f2fbd34fc43f9860b0ca5511f21b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Heart Ventricles
    97 rdf:type schema:DefinedTerm
    98 N0f2b6eaf94ea4f639a2ac959525a7394 rdf:first sg:person.010036473437.39
    99 rdf:rest Ne9e28ba06dd24c299aa622bb52b7bec8
    100 N1f48c2360bce4c00a346a94e6bd88a15 rdf:first sg:person.012520313742.11
    101 rdf:rest N4e12a3d5c3194066bbe78120cbf3e2f6
    102 N2ba1428aa018489493f72e136a6391bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Adult
    104 rdf:type schema:DefinedTerm
    105 N307301b2eac8422bb0ffa8d73da37243 schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 N3ef916cbbf3b4a1caaf6a1ae80ec74cd schema:issueNumber 3
    108 rdf:type schema:PublicationIssue
    109 N4e12a3d5c3194066bbe78120cbf3e2f6 rdf:first sg:person.014053753361.52
    110 rdf:rest Nbb936348c64040dd868771511f888837
    111 N57a253dffc134183b5f4bb172a3b8738 rdf:first sg:person.01233430032.02
    112 rdf:rest Na6a651a6d59b49a79a588dc61b0ef384
    113 N5e31af57cb0844df8800fb7a9cd81e94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Fibrosis
    115 rdf:type schema:DefinedTerm
    116 N64fc2156b5a44ab9ac1d0292682012ad schema:volumeNumber 29
    117 rdf:type schema:PublicationVolume
    118 N7cdfe1df99c0488db8eb694429233862 rdf:first sg:person.01231743740.11
    119 rdf:rest N0f2b6eaf94ea4f639a2ac959525a7394
    120 N82ee39ddbcad474bb99950780e9f2d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Middle Aged
    122 rdf:type schema:DefinedTerm
    123 N87fdb36ce8184874b491f272b96138dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Heart Atria
    125 rdf:type schema:DefinedTerm
    126 N883fa2a042c14ecaa17da146abd0d986 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Aged
    128 rdf:type schema:DefinedTerm
    129 N89e3b7ef8a804e9eaf828883f5d2306e rdf:first sg:person.07476175635.44
    130 rdf:rest N57a253dffc134183b5f4bb172a3b8738
    131 N8b78e3b123904367a060149e09629acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Magnetic Resonance Imaging
    133 rdf:type schema:DefinedTerm
    134 N8b84e941b14f4ac382b96658a64d2423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Hypertension
    136 rdf:type schema:DefinedTerm
    137 Na6a651a6d59b49a79a588dc61b0ef384 rdf:first sg:person.01301543232.10
    138 rdf:rest Nd5ca2677c4bd443fae2e61e6dfcda5ae
    139 Nbb936348c64040dd868771511f888837 rdf:first sg:person.01305761173.69
    140 rdf:rest N89e3b7ef8a804e9eaf828883f5d2306e
    141 Nc17c43b399d242e582e801264acff457 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Male
    143 rdf:type schema:DefinedTerm
    144 Nc2fb9bd0eeea429b89ee79d872fa55dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Female
    146 rdf:type schema:DefinedTerm
    147 Nd5ca2677c4bd443fae2e61e6dfcda5ae rdf:first sg:person.0707305350.86
    148 rdf:rest N7cdfe1df99c0488db8eb694429233862
    149 Nd7eae1314e5d41dc98715802c02fefd6 schema:name readcube_id
    150 schema:value 123c6f3da4cdf0adef7f17ebb1d5b917011d2326452750063d4936701208af08
    151 rdf:type schema:PropertyValue
    152 Nd7f870971b544137bfa7a705ddb6894f schema:name nlm_unique_id
    153 schema:value 9114774
    154 rdf:type schema:PropertyValue
    155 Ne2253f9d685142189e24a1086070a656 schema:name dimensions_id
    156 schema:value pub.1107105596
    157 rdf:type schema:PropertyValue
    158 Ne6432d8de3724e78b6cd27762c9024ef schema:name doi
    159 schema:value 10.1007/s00330-018-5700-z
    160 rdf:type schema:PropertyValue
    161 Ne9e28ba06dd24c299aa622bb52b7bec8 rdf:first sg:person.013052324361.69
    162 rdf:rest Nf37ece63c56e43ce8c7867112883f594
    163 Nf37ece63c56e43ce8c7867112883f594 rdf:first sg:person.016327572612.22
    164 rdf:rest rdf:nil
    165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    166 schema:name Medical and Health Sciences
    167 rdf:type schema:DefinedTerm
    168 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Cardiorespiratory Medicine and Haematology
    170 rdf:type schema:DefinedTerm
    171 sg:grant.5142629 http://pending.schema.org/fundedItem sg:pub.10.1007/s00330-018-5700-z
    172 rdf:type schema:MonetaryGrant
    173 sg:grant.5143234 http://pending.schema.org/fundedItem sg:pub.10.1007/s00330-018-5700-z
    174 rdf:type schema:MonetaryGrant
    175 sg:journal.1289120 schema:issn 0938-7994
    176 1432-1084
    177 schema:name European Radiology
    178 rdf:type schema:Periodical
    179 sg:person.010036473437.39 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    180 schema:familyName Paton
    181 schema:givenName Julian F. R.
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010036473437.39
    183 rdf:type schema:Person
    184 sg:person.01231743740.11 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    185 schema:familyName Nightingale
    186 schema:givenName Angus K.
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231743740.11
    188 rdf:type schema:Person
    189 sg:person.01233430032.02 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    190 schema:familyName Burchell
    191 schema:givenName Amy E.
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233430032.02
    193 rdf:type schema:Person
    194 sg:person.012520313742.11 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    195 schema:familyName Rodrigues
    196 schema:givenName Jonathan C. L.
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012520313742.11
    198 rdf:type schema:Person
    199 sg:person.01301543232.10 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    200 schema:familyName Ratcliffe
    201 schema:givenName Laura E. K.
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301543232.10
    203 rdf:type schema:Person
    204 sg:person.013052324361.69 schema:affiliation https://www.grid.ac/institutes/grid.418482.3
    205 schema:familyName Manghat
    206 schema:givenName Nathan E.
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052324361.69
    208 rdf:type schema:Person
    209 sg:person.01305761173.69 schema:affiliation https://www.grid.ac/institutes/grid.410421.2
    210 schema:familyName Dastidar
    211 schema:givenName Amardeep Ghosh
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305761173.69
    213 rdf:type schema:Person
    214 sg:person.014053753361.52 schema:affiliation https://www.grid.ac/institutes/grid.410421.2
    215 schema:familyName Erdei
    216 schema:givenName Tamas
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014053753361.52
    218 rdf:type schema:Person
    219 sg:person.016327572612.22 schema:affiliation https://www.grid.ac/institutes/grid.418482.3
    220 schema:familyName Hamilton
    221 schema:givenName Mark C. K.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327572612.22
    223 rdf:type schema:Person
    224 sg:person.0707305350.86 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    225 schema:familyName Hart
    226 schema:givenName Emma C.
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707305350.86
    228 rdf:type schema:Person
    229 sg:person.07476175635.44 schema:affiliation https://www.grid.ac/institutes/grid.410421.2
    230 schema:familyName Szantho
    231 schema:givenName Gergley
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476175635.44
    233 rdf:type schema:Person
    234 sg:pub.10.1038/hr.2009.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013968345
    235 https://doi.org/10.1038/hr.2009.41
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/hr.2009.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025965733
    238 https://doi.org/10.1038/hr.2009.89
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nature24676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092657209
    241 https://doi.org/10.1038/nature24676
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/1532-429x-13-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048829431
    244 https://doi.org/10.1186/1532-429x-13-40
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1186/1532-429x-13-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021051110
    247 https://doi.org/10.1186/1532-429x-13-42
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1186/1532-429x-15-99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016037889
    250 https://doi.org/10.1186/1532-429x-15-99
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1186/s12968-014-0099-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052425641
    253 https://doi.org/10.1186/s12968-014-0099-4
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1186/s12968-015-0176-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022709866
    256 https://doi.org/10.1186/s12968-015-0176-3
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1186/s12968-017-0327-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083735060
    259 https://doi.org/10.1186/s12968-017-0327-9
    260 rdf:type schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1083085729 schema:CreativeWork
    262 https://doi.org/10.1002/clc.4960200609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024910072
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/0735-1097(88)90416-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020775185
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.ahj.2008.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024088590
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.cardfail.2016.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032322392
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.jacc.2017.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101112169
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.jcmg.2014.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053308148
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.jcmg.2015.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003175307
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.media.2007.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050536037
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/s0002-9149(98)00452-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036433658
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/s0735-1097(03)00943-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022554711
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1080/10976640600572889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058381128
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1081/jcmr-120016383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058431659
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1081/jcmr-200036170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058431783
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1093/ajh/hpt001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059382075
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1093/ehjci/jes102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044619179
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1093/ehjci/jeu082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007406037
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/ehjci/jew117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031180051
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/ejechocard/jeq175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051391099
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/eurheartj/ehm037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028551384
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/eurheartj/ehs188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013620339
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/eurheartj/eht151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026649630
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/eurjhf/hft087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039244429
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1109/tmi.2007.903693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061695088
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1136/heartjnl-2011-301388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033968271
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1136/heartjnl-2016-309576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025637589
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1148/radiology.191.1.8134560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082666924
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1161/circimaging.115.003285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023672591
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1161/circimaging.115.004299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343315
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1161/jaha.114.000790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027859693
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1371/journal.pone.0162599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010683768
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.3109/10641963.2014.933962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035901633
    323 rdf:type schema:CreativeWork
    324 https://www.grid.ac/institutes/grid.410421.2 schema:alternateName University Hospitals Bristol NHS Foundation Trust
    325 schema:name Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK
    326 rdf:type schema:Organization
    327 https://www.grid.ac/institutes/grid.418482.3 schema:alternateName Bristol Royal Infirmary
    328 schema:name Department of Radiology, Bristol Royal Infirmary, University Bristol NHS Foundation Trust, Bristol, UK
    329 rdf:type schema:Organization
    330 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
    331 schema:name BHI CardioNomics Research Group, Clinical Research and Imaging Centre-Bristol, University of Bristol, Bristol, UK
    332 Department of Cardiovascular Magnetic Resonance, Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, BS2 8HW, Bristol, UK
    333 Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust, Combe Park, BA1 3NG, Bath, UK
    334 School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Science, University of Bristol, Bristol, UK
    335 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...