Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge View Full Text


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Article Info

DATE

2018-07-10

AUTHORS

Saba Shirvani, Paweł Tokarczuk, Ben Statton, Marina Quinlan, Alaine Berry, James Tomlinson, Peter Weale, Bernd Kühn, Declan P. O’Regan

ABSTRACT

ObjectivesWe investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1.MethodsIn a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots.ResultsInter-study correlation of whole-kidney RBF was good for both single-TI (r2 = 0.90), and multi-TI ASL (r2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant.ConclusionsFree-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge.Key points• Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T.• This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T1during free breathing.• This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge. More... »

PAGES

232-240

References to SciGraph publications

  • 2014-03-06. Comparison of ASL and DCE MRI for the non-invasive measurement of renal blood flow: quantification and reproducibility in EUROPEAN RADIOLOGY
  • 2016-01-27. A T1 and ECV phantom for global T1 mapping quality assurance: The T1 mapping and ECV standardisation in CMR (T1MES) program in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2017-10-09. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI) in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2016-09-22. A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance—the T1 Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program in JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
  • 2016-07-21. New Magnetic Resonance Imaging Index for Renal Fibrosis Assessment: A Comparison between Diffusion-Weighted Imaging and T1 Mapping with Histological Validation in SCIENTIFIC REPORTS
  • 2014-01-31. Inter-study reproducibility of arterial spin labelling magnetic resonance imaging for measurement of renal perfusion in healthy volunteers at 3 Tesla in BMC NEPHROLOGY
  • 2016-04-12. Radiologic imaging of the renal parenchyma structure and function in NATURE REVIEWS NEPHROLOGY
  • 2012-01-13. Repeatability of renal arterial spin labelling MRI in healthy subjects in MAGNETIC RESONANCE MATERIALS IN PHYSICS, BIOLOGY AND MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00330-018-5628-3

    DOI

    http://dx.doi.org/10.1007/s00330-018-5628-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105456148

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29992384


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    27 schema:description ObjectivesWe investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1.MethodsIn a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots.ResultsInter-study correlation of whole-kidney RBF was good for both single-TI (r2 = 0.90), and multi-TI ASL (r2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant.ConclusionsFree-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge.Key points• Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T.• This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T1during free breathing.• This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge.
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    37 Pearson correlation
    38 RBF
    39 Repeated measures
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    41 T1
    42 Ti
    43 agreement
    44 approach
    45 arrival time
    46 arterial spin labeling
    47 authorities
    48 background suppression
    49 baseline
    50 blood pressure
    51 bolus arrival time
    52 breathing
    53 challenges
    54 changes
    55 characteristics
    56 consent
    57 correlation
    58 cortex
    59 effect
    60 estimates
    61 feasibility
    62 free breathing
    63 glyceryl trinitrate
    64 haemodynamic characteristics
    65 haemodynamic parameters
    66 healthy volunteers
    67 higher estimates
    68 images
    69 imaging
    70 inversion recovery preparation
    71 inversion time
    72 kidney
    73 labeling
    74 mapping
    75 maps
    76 measurements
    77 measures
    78 median T1
    79 medulla
    80 ms
    81 multiple inversion times
    82 parameters
    83 parametric mapping
    84 parametric maps
    85 perfusion
    86 pharmacological challenge
    87 plots
    88 preparation
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    91 renal cortex
    92 renal imaging
    93 renal perfusion
    94 reproducibility
    95 simultaneous mapping
    96 simultaneous measurement
    97 spin labeling
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    101 systolic blood pressure
    102 technique
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