Left ventricular myocardial deformation in Takotsubo syndrome: a cardiovascular magnetic resonance myocardial feature tracking study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06-07

AUTHORS

Thomas Stiermaier, Torben Lange, Amedeo Chiribiri, Christian Möller, Tobias Graf, Christina Villnow, Uwe Raaz, Adriana Villa, Johannes T. Kowallick, Joachim Lotz, Gerd Hasenfuß, Holger Thiele, Andreas Schuster, Ingo Eitel

ABSTRACT

ObjectivesThis study assessed the applicability and prognostic value of cardiovascular magnetic resonance (CMR) left ventricular deformation analysis in Takotsubo syndrome (TTS).MethodsCMR-feature tracking was performed blinded in a core laboratory to determine circumferential (CS), radial (RS) and longitudinal strain (LS) in 141 TTS patients participating in this cohort study. A subgroup of consecutive TTS patients (n = 20) was compared with age- and sex-matched controls with anterior ST-segment elevation myocardial infarction (STEMI) and non-STEMI as well as healthy subjects.ResultsMedian global CS, RS and LS were -19%, 19% and -12%, respectively. Apical ballooning was associated with significantly lower global CS (p < 0.01) and LS (p < 0.01) compared with midventricular and basal ballooning. Global RS was lowest in patients with basal ballooning (p < 0.01). Segmental analysis resulted in a reliable discrimination of different ballooning patterns using CS and LS. Strain values were significantly lower in TTS compared with non-STEMI patients and healthy subjects, whereas STEMI patients showed similar values. While global CS and RS were not associated with long-term mortality, global LS (cutoff -14.75%) was identified as a potential parameter for long-term risk stratification (mortality rate 17.9% versus 2.5%; p = 0.02).ConclusionsThe transient contraction abnormalities in TTS can be quantitatively assessed with CMR-feature tracking. GLS is a potential determinant of outcome in TTS, which, however, requires further validation.Key Points• Cardiovascular magnetic resonance myocardial feature tracking enables accurate assessment of regional and global left ventricular dysfunction in Takotsubo syndrome (TTS).• Global strain in TTS is similar to patients with anterior STEMI and lower compared with non-STEMI and healthy subjects.• Global longitudinal strain is a potential tool for risk prediction in TTS patients. More... »

PAGES

5160-5170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-018-5475-2

DOI

http://dx.doi.org/10.1007/s00330-018-5475-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104452755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29882071


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24 schema:description ObjectivesThis study assessed the applicability and prognostic value of cardiovascular magnetic resonance (CMR) left ventricular deformation analysis in Takotsubo syndrome (TTS).MethodsCMR-feature tracking was performed blinded in a core laboratory to determine circumferential (CS), radial (RS) and longitudinal strain (LS) in 141 TTS patients participating in this cohort study. A subgroup of consecutive TTS patients (n = 20) was compared with age- and sex-matched controls with anterior ST-segment elevation myocardial infarction (STEMI) and non-STEMI as well as healthy subjects.ResultsMedian global CS, RS and LS were -19%, 19% and -12%, respectively. Apical ballooning was associated with significantly lower global CS (p < 0.01) and LS (p < 0.01) compared with midventricular and basal ballooning. Global RS was lowest in patients with basal ballooning (p < 0.01). Segmental analysis resulted in a reliable discrimination of different ballooning patterns using CS and LS. Strain values were significantly lower in TTS compared with non-STEMI patients and healthy subjects, whereas STEMI patients showed similar values. While global CS and RS were not associated with long-term mortality, global LS (cutoff -14.75%) was identified as a potential parameter for long-term risk stratification (mortality rate 17.9% versus 2.5%; p = 0.02).ConclusionsThe transient contraction abnormalities in TTS can be quantitatively assessed with CMR-feature tracking. GLS is a potential determinant of outcome in TTS, which, however, requires further validation.Key Points• Cardiovascular magnetic resonance myocardial feature tracking enables accurate assessment of regional and global left ventricular dysfunction in Takotsubo syndrome (TTS).• Global strain in TTS is similar to patients with anterior STEMI and lower compared with non-STEMI and healthy subjects.• Global longitudinal strain is a potential tool for risk prediction in TTS patients.
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