Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Khoschy Schawkat, Michael Ith, Andreas Christe, Wolfgang Kühn, Yojena Chittazhathu, Lauren Bains, Val Murray Runge, Johannes T. Heverhagen

ABSTRACT

OBJECTIVES: To investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation. MATERIAL AND METHODS: An (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25-40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation. RESULTS: The mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements. CONCLUSION: Dynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting. KEY POINTS: • ASL imaging of the pancreas permitted quantification of pancreatic perfusion • Secretin stimulation led to a significant increase in pancreatic perfusion • The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements. More... »

PAGES

2389-2396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-017-5227-8

DOI

http://dx.doi.org/10.1007/s00330-017-5227-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100199376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29302785


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43 schema:description OBJECTIVES: To investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation. MATERIAL AND METHODS: An (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25-40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation. RESULTS: The mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements. CONCLUSION: Dynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting. KEY POINTS: • ASL imaging of the pancreas permitted quantification of pancreatic perfusion • Secretin stimulation led to a significant increase in pancreatic perfusion • The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements.
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