Dynamic contrast-enhanced and diffusion-weighted MR imaging in the characterisation of small, non-palpable solid testicular tumours View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-30

AUTHORS

Lucia Manganaro, Matteo Saldari, Carlotta Pozza, Valeria Vinci, Daniele Gianfrilli, Ermanno Greco, Giorgio Franco, Maria Eleonora Sergi, Michele Scialpi, Carlo Catalano, Andrea M. Isidori

ABSTRACT

ObjectivesTo explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.MethodsWe calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space volume fraction (Ve) and initial area under the curve (iAUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated.ResultsEpeak, WIR, Ktrans , Kep and iAUC were higher and TTP shorter in benign compared to malignant lesions (p < 0.05). All tumours had similar ADC values (p > 0.07). Subgroup analysis limited to the most frequent histologies – Leydig cell tumours (LCTs) and seminomas – replicated the findings of the entire set. Best diagnostic cutoff value for identification of seminomas: Ktrans ≤0.135 min−1, Kep ≤0.45 min−1, iAUC ≤10.96, WIR ≤1.11, Epeak ≤96.72, TTP >99 s.ConclusionsDCE-MRI parameters are valuable in differentiating between benign and malignant small, non-palpable testicular tumours, especially when characterising LCTs and seminomas.Key Points• DCE-MRI may be used to differentiate benign from malignant non-palpable testicular tumours.• Seminomas show lower Ktrans, Kep and iAUC values.• ADC values are not valuable in differentiating seminomas from LCTs.• Semiquantitative DCE-MRI may be used to characterise small, solid testicular tumours. More... »

PAGES

554-564

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-017-5013-7

DOI

http://dx.doi.org/10.1007/s00330-017-5013-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091396141

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28856410


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    "description": "ObjectivesTo explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.MethodsWe calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space volume fraction (Ve) and initial area under the curve (iAUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated.ResultsEpeak, WIR, Ktrans , Kep and iAUC were higher and TTP shorter in benign compared to malignant lesions (p\u2009<\u20090.05). All tumours had similar ADC values (p > 0.07). Subgroup analysis limited to the most frequent histologies \u2013 Leydig cell tumours (LCTs) and seminomas \u2013 replicated the findings of the entire set. Best diagnostic cutoff value for identification of seminomas: Ktrans \u22640.135 min\u22121, Kep \u22640.45 min\u22121, iAUC \u226410.96, WIR \u22641.11, Epeak \u226496.72, TTP >99 s.ConclusionsDCE-MRI parameters are valuable in differentiating between benign and malignant small, non-palpable testicular tumours, especially when characterising LCTs and seminomas.Key Points\u2022 DCE-MRI may be used to differentiate benign from malignant non-palpable testicular tumours.\u2022 Seminomas show lower Ktrans, Kep and iAUC values.\u2022 ADC values are not valuable in differentiating seminomas from LCTs.\u2022 Semiquantitative DCE-MRI may be used to characterise small, solid testicular tumours.", 
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26 schema:description ObjectivesTo explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.MethodsWe calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space volume fraction (Ve) and initial area under the curve (iAUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated.ResultsEpeak, WIR, Ktrans , Kep and iAUC were higher and TTP shorter in benign compared to malignant lesions (p < 0.05). All tumours had similar ADC values (p > 0.07). Subgroup analysis limited to the most frequent histologies – Leydig cell tumours (LCTs) and seminomas – replicated the findings of the entire set. Best diagnostic cutoff value for identification of seminomas: Ktrans ≤0.135 min−1, Kep ≤0.45 min−1, iAUC ≤10.96, WIR ≤1.11, Epeak ≤96.72, TTP >99 s.ConclusionsDCE-MRI parameters are valuable in differentiating between benign and malignant small, non-palpable testicular tumours, especially when characterising LCTs and seminomas.Key Points• DCE-MRI may be used to differentiate benign from malignant non-palpable testicular tumours.• Seminomas show lower Ktrans, Kep and iAUC values.• ADC values are not valuable in differentiating seminomas from LCTs.• Semiquantitative DCE-MRI may be used to characterise small, solid testicular tumours.
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33 schema:keywords ADC values
34 Benign
35 ConclusionsDCE-MRI parameters
36 DCE-MRI
37 DCE-MRI parameters
38 DWI signal intensity
39 Epeak
40 Kep
41 Ktrans
42 LCT
43 MR
44 MethodsWe
45 ObjectivesTo
46 ResultsEpeak
47 TTP
48 WIR
49 analysis
50 apparent diffusion coefficient (ADC) values
51 area
52 best diagnostic cutoff value
53 cell tumors
54 characterisation
55 coefficient values
56 constants
57 contrast-enhanced magnetic resonance imaging
58 curves
59 cutoff value
60 diagnostic cutoff value
61 diffusion coefficient (ADC) values
62 diffusion-weighted (DW) MRI
63 diffusion-weighted MR
64 dynamic contrast-enhanced magnetic resonance imaging
65 enhancement
66 enhancement ratio
67 entire set
68 extracellular space volume fraction
69 extravascular extracellular space volume fraction
70 findings
71 fraction
72 frequent histologies – Leydig cell tumours
73 histologies – Leydig cell tumours
74 iAUC
75 iAUC values
76 identification
77 identification of seminomas
78 imaging
79 initial area
80 intensity
81 lesions
82 lower Ktrans
83 magnetic resonance imaging
84 malignant lesions
85 malignant non-palpable testicular tumours
86 non-palpable solid testicular tumours
87 non-palpable testicular tumours
88 parameters
89 peak
90 peak enhancement
91 percentage
92 quantitative parameters
93 rate
94 rate constants
95 ratio
96 resonance imaging
97 role
98 seminoma
99 semiquantitative DCE-MRI
100 set
101 signal enhancement ratio
102 signal intensity
103 similar ADC values
104 solid testicular tumours
105 space volume fraction
106 subgroup analysis
107 testicular tumors
108 time
109 transfer constants
110 tumors
111 values
112 volume fraction
113 volume transfer constant
114 wash
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